Time-course of pain threshold after continuous theta burst stimulation of primary somatosensory cortex in pain-free subjects

Rao, Nishant; Chen, Yen‐Ting; Ramirez, Regan; Tran, John; Li, Sheng; Parikh, Pranav J.

doi:10.1016/j.neulet.2020.134760

Cited by 10 publications

(2 citation statements)

References 48 publications

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“…After their inclusion, participants were randomly assigned to one of two groups: (1) SRPS and (2) No SRPS. In spite of their group allocation, each participant took part in two single-day laboratory visits, one with active rTMS and the other with a sham intervention, separated by at least 1 week to avoid any potential carry-over effects of the first visit on the other ( 22 , 47 , 48 ). Each visit included two consecutive sessions of rTMS (or sham) spaced 10 min apart ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

Conditioning to Enhance the Effects of Repetitive Transcranial Magnetic Stimulation on Experimental Pain in Healthy Volunteers

et al. 2022

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ObjectiveIn this proof-of-concept study we sought to explore whether the combination of conditioning procedure based on a surreptitious reduction of a noxious stimulus (SRPS) could enhance rTMS hypoalgesic effects [i.e., increase heat pain threshold (HPT)] and augment intervention expectations in a healthy population.MethodsForty-two healthy volunteers (19–35 years old) were enrolled in a randomized crossover-controlled study and were assigned to one of two groups: (1) SRPS and (2) No SRPS. Each participant received two consecutive sessions of active or sham rTMS over the M1 area of the right hand on two visits (1) active, (2) sham rTMS separated by at least one-week interval. HPT and the temperature needed to elicit moderate heat pain were measured before and after each rTMS intervention on the right forearm. In the SRPS group, conditioning consisted of deliberately decreasing thermode temperature by 3°C following intervention before reassessing HPT, while thermode temperature was held constant in the No SRPS group. Intervention expectations were measured before each rTMS session.ResultsSRPS conditioning procedure did not enhance hypoalgesic effects of rTMS intervention, neither did it modify intervention expectations. Baseline increases in HPT were found on the subsequent intervention session, suggesting variability of this measure over time, habituation or a possible “novelty effect.”ConclusionUsing a SRPS procedure in healthy volunteers did not enhance rTMS modulating effects on experimental pain sensation (i.e., HPT). Future studies are therefore needed to come up with a conditioning procedure which allows significant enhancement of rTMS pain modulating effects in healthy volunteers.

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Section: Methodsmentioning

confidence: 99%

Conditioning to Enhance the Effects of Repetitive Transcranial Magnetic Stimulation on Experimental Pain in Healthy Volunteers

et al. 2022

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“…These findings support the general consensus that rTMS exerts a multitude of mechanisms that could differentially modulate specific types of pain and indicate an acute analgesic effect that could be independent from the maladaptive plasticity associated with chronic pain. Indeed, rTMS application is shown to activate opioid-mediated analgesia of acute pain in healthy individuals [79], induce dose-dependent immediate analgesia following stimulation in patients with intractable neuropathic pain [80] and elevate electrical pain thresholds up to 40 min following application over the somatosensory cortex of healthy subjects without altering the excitability of the M1 cortex [81]. Therefore, rTMS carries significant potentials in both: prevention of acuteto-chronic pain transition, through acute analgesia and prevention of maladaptive plasticity, and treatment of chronic pain through reversal of maladaptive plasticity.…”

Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

Advances in targeting central sensitization and brain plasticity in chronic pain

Bazzari

2022

Egypt J Neurol Psychiatry Neurosurg

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Maladaptation in sensory neural plasticity of nociceptive pathways is associated with various types of chronic pain through central sensitization and remodeling of brain connectivity. Within this context, extensive research has been conducted to evaluate the mechanisms and efficacy of certain non-pharmacological pain treatment modalities. These include neurostimulation, virtual reality, cognitive therapy and rehabilitation. Here, we summarize the involved mechanisms and review novel findings in relation to nociceptive desensitization and modulation of plasticity for the management of intractable chronic pain and prevention of acute-to-chronic pain transition.

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Modulation of somatosensation by transcranial magnetic stimulation over somatosensory cortex: a systematic review

2023

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Time-course of pain threshold after continuous theta burst stimulation of primary somatosensory cortex in pain-free subjects

Cited by 10 publications

References 48 publications

Conditioning to Enhance the Effects of Repetitive Transcranial Magnetic Stimulation on Experimental Pain in Healthy Volunteers

Conditioning to Enhance the Effects of Repetitive Transcranial Magnetic Stimulation on Experimental Pain in Healthy Volunteers

Advances in targeting central sensitization and brain plasticity in chronic pain

Modulation of somatosensation by transcranial magnetic stimulation over somatosensory cortex: a systematic review

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