Time-dependent effect of chronic UV irradiation on superoxide dismutase and catalase activity in hairless mice skin

Okada, Katsuyuki; Takahashi, Yumiko; Ohnishi, Kazunori; Ishikawa, Osamu; Miyachi, Yoshiki

doi:10.1016/0923-1811(94)90052-3

Cited by 54 publications

(36 citation statements)

References 13 publications

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“…25,33) While the CAT protein was destroyed by UV irradiation, SOD was unaffected 25) and even induced by repeated exposure to UVB. 34) These results suggests that skin SOD and CAT activities are not coordinately regulated by UV irradiation.…”

Section: Discussionmentioning

confidence: 60%

Fructose 1,6-Diphosphate Alleviates UV-Induced Oxidative Skin Damage in Hairless Mice

Ahn

Hwang

Lee

2007

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 60%

Fructose 1,6-Diphosphate Alleviates UV-Induced Oxidative Skin Damage in Hairless Mice

Ahn

Hwang

Lee

2007

Biological & Pharmaceutical Bulletin

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“…However, continual cumulative stress may overwhelm the capacity of this system, with SOD1 activity being significantly decreased in the skin (24). In the present study, chronic UVB irradiation of the skin induced a significant reduction in SOD1 immunoreactivity, its protein content and activity compared to control.…”

Section: Discussionmentioning

confidence: 51%

“…It has been reported that SOD1 activity is significantly suppressed by single-dose UVB irradiation (23), whereas it is induced by repeated exposure to UVB in response to chronic photo-oxidative stress (24). However, continual cumulative stress may overwhelm the capacity of this system, with SOD1 activity being significantly decreased in the skin (24).…”

Section: Discussionmentioning

confidence: 99%

An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin

Hwang

Yoo

Kim³

et al. 2006

Braz J Med Biol Res

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Over the last decades, the incidence of ultraviolet B (UVB)-related skin problems has been increasing. Damages induced by UVB radiation are related to mutations that occur as a result of direct DNA damage and/or the production of reactive oxygen species. We investigated the anti-oxidant effects of a Polygonum multiflorum thumb extract against skin damage induced by UVB irradiation. Female SKH-1 hairless mice were divided into three groups: control (N = 7), distilled water-(N = 10), and P. multiflorum extract-treated (PM, N = 10) groups. The PM (10 g) was extracted with 100 mL distilled water, cryo-dried and 9.8 g was obtained. The animals received a topical application of 500 µL distilled water or PM extract (1, 2, 4, 8, and 16%, w/v, dissolved in distilled water) for 30 min after UVB irradiation (wavelength 280-320 nm, 300 mJ/cm 2 ; 3 min) of the dorsal kin for 14 days, and skin immunohistochemistry and Cu,Zn-superoxide dismutase (SOD1) activity were determined. SOD1 immunoreactivity, its protein levels and activities in the skin were significantly reduced by 70% in the distilled water-treated group after UVB irradiation compared to control. However, in the PM extract-treated groups, SOD1 immunoreactivity and its protein and activity levels increased in a dose-dependent manner (1-16%, w/v, PM extract) compared to the distilled water-treated group. SOD1 protein levels and activities in the groups treated with 8 and 16%, w/v, PM extract recovered to 80-90% of the control group levels after UVB. These results suggest that PM extract strongly inhibits the destruction of SOD1 by UV radiation and probably contains anti-skin photoaging agents.

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“…In the certain extent, this result is supported by numerous studies, demonstrating that activities of SOD, CAT, glutathione reductase, ubiquinol, and Alfa tocopherol were reduced after a single UVB irradiation. However, when exposure to UVB was prolonged for more than 12 weeks, the activity of SOD was also raised 37 .…”

Section: Discussionmentioning

confidence: 99%

Pimpinella alpina Molk Administration is Capable of Increasing Antioxidant and Decreasing Prooxidant Level following UVB Irradiation

Nasihun

Widayati

2018

Journal of Natural Remedies

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Time-dependent effect of chronic UV irradiation on superoxide dismutase and catalase activity in hairless mice skin

Cited by 54 publications

References 13 publications

Fructose 1,6-Diphosphate Alleviates UV-Induced Oxidative Skin Damage in Hairless Mice

Fructose 1,6-Diphosphate Alleviates UV-Induced Oxidative Skin Damage in Hairless Mice

An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin

Pimpinella alpina Molk Administration is Capable of Increasing Antioxidant and Decreasing Prooxidant Level following UVB Irradiation

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