Time-dependent melatonin analgesia in mice: inhibition by opiate or benzodiazepine antagonism

Golombék, Diego A.; Escolar, Esteban; Burin, Leila; Sánchez, María del Mar; Cardinali, Daniel P.

doi:10.1016/0014-2999(91)90119-b

Cited by 118 publications

(91 citation statements)

References 28 publications

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“…In addition, melatonin improves wound healing in pinealectomized animals [38]. Melatonin also reduces pain in rodents [39,40,41,42] due to a direct action on the opiatergic centers in the central nervous system [20,40]. In the present study, the normal daily variation in melatonin was restored 1 day after the surgery, suggesting that this is the time required to initiate the healing processes that follows the surgery.…”

Section: Discussionsupporting

confidence: 52%

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

Tatsch-Dias¹,

Levandovski

Souza³

et al. 2013

Neuroimmunomodulation

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Objective: Activation of the immune-pineal axis induces a transient reduction in nocturnal melatonin in the plasma during the proinflammatory phase of an innate immune response to allow the proper migration of leukocytes to the lesion site. This transient reduction should be regulated by inflammatory mediators, which are responsible for the fine-tuning of the process. In the present study, we measured the pre- and postoperative serum concentrations of melatonin, tumor necrosis factor (TNF) and cortisol in women who underwent an elective hysterectomy and correlated the variation in melatonin with postoperative pain. Methods: We evaluated 12 women who had an abdominal hysterectomy. Blood was collected at 10.00 and 22.00 h 1 week and 1 day before the surgery, on the 1st and 2nd days after the surgery and at 22.00 h on the day of the surgery. Results: On the night after the surgery, there was no melatonin detected at 22.00 h. High TNF levels were accompanied by a lower nocturnal melatonin output, higher postoperative pain according to a visual analog scale and the request of higher doses of analgesics. In addition, low cortisol levels were accompanied by a lower nocturnal melatonin output. Conclusion: Our results confirm that the same antagonistic pattern between TNF and glucocorticoids observed in cultured pineal glands also occurs in humans. This integrative pattern suggests that the cross talk between the immune and endocrine system orchestrates longitudinal changes in pineal activity, reinforcing the hypothesis of an immune-pineal axis.

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Section: Discussionsupporting

confidence: 52%

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

Tatsch-Dias¹,

Levandovski

Souza³

et al. 2013

Neuroimmunomodulation

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“…Melatonin receptors are located in the spinal cord and various brain regions (Vitte et al, 1990;Stankov et al, 1991;Morgan et al, 1994;Zahn et al, 2003). It has been shown that melatonin produces a transient antinociceptive effect in rats and mice (Yu et al, 2000a, b;Tu et al, 2004;Onal et al, 2004), modulates lipopolysaccharideinduced hyperalgesia possibly via its influence on the role of proinflammatory cytokines in sensory neurons , and interacts with opioid antinociception (Golombek et al, 1991;Pang et al, 2001;Li et al, 2005;Shavali et al, 2005). In clinical studies, melatonin has been reported to reduce cluster headache, irritable bowel syndrome, and fibromyalgia (Leone et al, 1996;Citera et al, 2000;Song et al, 2005), although the relationship between depression and chronic pain was not specifically examined in these clinical reports.…”

Section: Discussionmentioning

confidence: 99%

Exacerbated mechanical allodynia in rats with depression-like behavior

et al. 2008

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Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior. Administration of melatonin into the anterior cingular cortex contralateral to peripheral nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of depressionlike behavior in WKY rats. Moreover, there was a lower plasma melatonin concentration and a lower melatonin receptor expression in the anterior cingular cortex in WKY rats than in Wistar rats. These results suggest that there exists a reciprocal relationship between mechanical allodynia and depression-like behavior and the melotoninergic system in the anterior cingular cortex might play an important role in the interaction between pain and depression.

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“…[16][17][18] Likewise, orally administered tryptophan was demonstrated to have a sedative effect in healthy individuals, [19][20][21] which is believed to be mediated through a nonserotonin mechanism. 22 Melatonin, another hormone derived from tryptophan, was repeatedly demonstrated to induce sedative effects [23][24][25] and thus may likely mediate the tryptophaninduced sedative effects. Considering the fact that tryptophan and melatonin are abundant in Night milk, [4][5][6] it is possible that the sedative effect of Night milk may be attributable to these substances.…”

Section: Discussionmentioning

confidence: 99%

Milk Collected at Night Induces Sedative and Anxiolytic-Like Effects and Augments Pentobarbital-Induced Sleeping Behavior in Mice

Joy

HongEunyoung

Bryan

et al. 2015

Journal of Medicinal Food

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Milk has long been known and used to promote sleep. The sleep-promoting effect of milk has been attributed to its psychological associations (i.e., the memory of a mother giving milk at bedtime) and its rich store of sleep-promoting constituents (e.g., tryptophan). Studies have shown that milk harvested at night (Night milk) contains exceptionally high amounts of tryptophan and melatonin. In the present study, we evaluated the psychopharmacological properties of Night milk, particularly its probable sleep-promoting/enhancing, and anxiolytic effects. Night milk was orally administered to ICR mice at various concentrations (100, 200, or 300 mg/kg). An hour after administration, assessment of its sedative (open-field and rotarod tests) and sedative sleep-potentiating effects (pentobarbital-induced sleeping test) was conducted. For comparison, the effects of Day milk (daytime milking) were also assessed. In addition, the effects of Night milk on anxiety behavior (elevated plus maze [EPM] test) and electroencephalographic (EEG) waves were evaluated. Night milk-treated animals exhibited decreased spontaneous locomotion (open-field test) and impaired motor balance and coordination (rotarod test). Furthermore, Night milk shortened the sleep onset and prolonged the sleep duration induced by pentobarbital sodium. These effects were comparable to that of diazepam. In addition, Night milk significantly increased the percentage of time spent and entries into the open arms of the EPM, indicating that it also has anxiolytic effects. No significant changes in EEG waves were observed. Altogether, these findings suggest that Night milk is a promising natural aid for sleep-and anxiety-related disturbances.

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Time-dependent melatonin analgesia in mice: inhibition by opiate or benzodiazepine antagonism

Cited by 118 publications

References 28 publications

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

Exacerbated mechanical allodynia in rats with depression-like behavior

Milk Collected at Night Induces Sedative and Anxiolytic-Like Effects and Augments Pentobarbital-Induced Sleeping Behavior in Mice

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