Time-domain terahertz spectroscopy of bioagent simulants

Fitch, Michael J.; Dodson, Caroline; Ziomek, Dunja S.; Osiander, Robert

doi:10.1117/12.579772

Cited by 8 publications

(5 citation statements)

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“…Previous work has also demonstrated spectroscopic features of bacteria originating from the combination of low frequency vibrational modes within cell components, with significant contribution from the DNA . In addition, by comparing the transmission spectra, some features of Bacillus spores are in common with dipicolinic acid , which is a major constituent of the spore coating. However, our results showed that, for living bacteria, intracellular water is undoubtedly the dominant factor contributing to the overall absorption spectra.…”

Section: Resultsmentioning

confidence: 95%

“…To date, relevant researches on using the THz technologies to detect bacteria mostly focus on spores of Bacillus species . By using the THZ photomixing spectrometer, two distinct signatures at 955 GHz and 1015 GHz were found for Bacillus thuringiensis , while three distinct signatures at 253 GHz, 418 GHz and 1037 GHz were observed in Bacillus subtillis .…”

Section: Introductionmentioning

confidence: 99%

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Rapid and label-free detection and assessment of bacteria by terahertz time-domain spectroscopy

et al. 2016

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Here we demonstrated the potential and applicability of terahertz (THz) spectroscopy to detect four commonly found bacteria in the infectious diseases. Besides the different spectral characteristics between bacterial species, THz absorption differences for living bacteria, dead bacteria and bacterial powder of the same species were also investigated. Our results revealed that small differences in water contents between bacterial cells account for distinct discrepancies of the absorption coefficients, which can be used for bacterial species identification. Furthermore, living and dead bacteria showed different absorption coefficients as a result of their different hydration levels, suggesting that THz spectroscopy can be used to rapidly assess the living state of bacteria under test. Our results clearly demonstrated the ability of THz spectroscopy for time-saving and label-free detection of bacteria with minimal sample preparation, potentially to be utilized for point-of-care tests in the near future. Schematic representation of bacterial detection by THz spectroscopy. Different bacteria have distinctive absorption coefficients as a result of their different water contents.

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Rapid and label-free detection and assessment of bacteria by terahertz time-domain spectroscopy

et al. 2016

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“…DPA is a unique component of Bacillus spores, constituting 5 to 15 % of the entire dry weight of spores, and it does not exist in vegetative cells (Paidhungat et al 2000). Therefore, the transmission spectrum of DPA shares common features with the spectra of Bacillus thuringiensis and Bacillus globigii, but evidently differs from that of Aspergillus niger (Fitch et al 2004). Moreover, the distinct spectral signature at 1.54 THz of DPA powder coincides with the 1.538 THz peak observed in B. subtilis spores (Yu et al 2005).…”

Section: Bacterial Component Characterization By Thz Spectroscopymentioning

confidence: 96%

Terahertz spectroscopy for bacterial detection: opportunities and challenges

Xiang

Yang

Luo

et al. 2016

Appl Microbiol Biotechnol

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The demand for advanced bacterial detection tools is continuously increasing, promoted by its significant benefits in various applications. For instance, in the medical field, these tools would facilitate decision making about more tailored therapies once the infection source has been identified. In the past few years, terahertz (THz = 10(12) Hz) spectroscopy has also shown potential as a novel bacterial detection modality due to its unique advantages. Impressive breakthroughs have been achieved in this field related to bacterial component characterization, spore identification, and cell detection. However, some intrinsic limitations and technical bottlenecks have led to some debates about the practicability of its clinical adoption. In this review, we summarize the progress achieved in this field and discuss some challenges and strategies for future implementation of practical applications.

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“…This is a region of the electromagnetic spectrum between the microwave and infrared bands. Initial applications for THz electromagnetic waves have focused on spectroscopic applications in astronomy [4], security application for chemical, biological, and weapons detection [5][6][7][8][9], and medical applications [10,11]. Until recently, short pulse sources and detectors were nonexistent in this range, limiting the viability of THz NDE applications.…”

Section: Introductionmentioning

confidence: 99%

Terahertz NDE application for corrosion detection and evaluation under Shuttle tiles

Anastasi¹,

Madaras

Seebo

et al. 2007

SPIE Proceedings

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Pulsed Terahertz NDE is being examined as a method to inspect for possible corrosion under Space Shuttle Tiles. Other methods such as ultrasonics, infrared, eddy current and microwave technologies have demonstrable shortcomings for tile NDE. This work applies Terahertz NDE, in the frequency range between 50 GHz and 1 THz, for the inspection of manufactured corrosion samples. The samples consist of induced corrosion spots that range in diameter (2.54 to 15.2 mm) and depth (0.036 to 0.787 mm) in an aluminum substrate material covered with tiles. Results of these measurements are presented for known corrosion flaws both covered and uncovered and for blind tests with unknown corrosion flaws covered with attached tiles. The Terahertz NDE system is shown to detect all artificially manufactured corrosion regions under a Shuttle tile with a depth greater than 0.13 mm.

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Time-domain terahertz spectroscopy of bioagent simulants

Cited by 8 publications

References 0 publications

Rapid and label-free detection and assessment of bacteria by terahertz time-domain spectroscopy

Rapid and label-free detection and assessment of bacteria by terahertz time-domain spectroscopy

Terahertz spectroscopy for bacterial detection: opportunities and challenges

Terahertz NDE application for corrosion detection and evaluation under Shuttle tiles

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