Time-Dosage Relationship in the Treatment of Treponemal Diseases with a New Combination of Three Penicillin Salts. Laboratory and Clinical Basis for Effective Therapy1

A Comparison of the in vitro Sensitivity of Gonococci to Penicillin with the Results of Treatment

“…Tommila and Savolainen (1955) compared the results of injecting intramuscularly 600,000 units aqueous procaine penicillin preparations from different sources, and Table XI shows the wide range of values they obtained. Rein, Buckwalter, Mann, Landy, and Flax (1953) showed similar variations in patients injected intramuscularly with 1,200,000 units of Penidural A.P. (Table XI).…”

Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people.

“…The growing bacteria then begin to swell and form protoplasts, which lyse as a result of osmotic pressure. Although T pallidum is not cultivatable in vitro the mechanism of the action of penicillin is considered to be the same ( 41 42; and (c) therefore such a serum concentration maintained for [7][8][9][10] days is considered adequate to kill all the T pallidum which have invaded an organism. 2 The results of our study have shown that for young subjects, with the standard dosages generally used in the treatment of syphilis when one or other of these complexes is used, it would be preferable to use benzathine bipenicillin, assuming the minimum active penicillin concentration to be 0 03 units/ml.…”