Abstract. The continuous evolution of life science ontologies requires the adaptation of their associated mappings. We propose two approaches for tackling this problem in a largely automatic way: (1) a compositionbased adaptation relying on the principle of mapping composition and (2) a diff-based adaptation algorithm individually handling change operations to update the mapping. Both techniques reuse unaffected correspondences, and adapt only the affected mapping part. We experimentally assess and confirm the effectiveness of our approaches for evolving mappings between large life science ontologies.