Time-gated viewing studies on tissuelike phantoms

Berg, Roger; Andersson‐Engels, Stefan; Jarlman, O.; Svanberg, Sune

doi:10.1364/ao.35.003432

Cited by 20 publications

(16 citation statements)

References 27 publications

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“…In time-resolved optical imaging experiments on breast phantoms one generally assumes that the reduced scattering factor of the breast tissue is of the order of 1 mm\, whereas the absorption factor of the breast tissue is of the order of 0.01 mm\, at a wavelength of 800 nm [24,67,68].…”

Section: Breast Tissue Imaging: Physical Basismentioning

confidence: 99%

“…without image processing) is possible [82]. Diffusive light imaging can be performed in the frequency domain [39,[83][84][85][86] or in the time domain [23][24][25]38,87]. In the former case a continuous intensity-modulated light source is used to generate diffusive monochromatic light-intensity waves in the medium.…”

Section: Light Propagation In Turbid Mediamentioning

confidence: 99%

“…More flexible than analytical methods are numerical methods, such as the finite element method (FEM) [127][128][129][130][131][132], the finite difference method (FDM) [24], the method of exact enumeration [133] and our method [104], described above. The basic idea of the FEM is that a model that satisfies the time-dependent diffusion equation is divided into elements, and an approximate solution to the equation is calculated over each element.…”

Section: Simulation Softwarementioning

confidence: 99%

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Computer simulation of time-resolved optical imaging of objects hidden in turbid media

et al. 1998

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Section: Breast Tissue Imaging: Physical Basismentioning

confidence: 99%

Section: Light Propagation In Turbid Mediamentioning

confidence: 99%

Section: Simulation Softwarementioning

confidence: 99%

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Computer simulation of time-resolved optical imaging of objects hidden in turbid media

et al. 1998

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“…A cylindrical shaped (8 cm diameter and 10 cm length) acetal resin rod (Delrin r ) is used to mimic background breast tissue which has similar optical properties to the breast fat ( 0 s ¼ 2:3 mm À1 and a ¼ 0:002 mm À1 ). 30 A hole, with a 5 mm diameter, is put on the side wall of the cylinder, which is shown in Fig. 4, which is located 1.8 cm below one end of the acetal rod and is¯lled with tumor-like liquid phantom.…”

Section: Resultsmentioning

confidence: 99%

“…[30][31][32][33][34] Black ink is commonly used in phantom studies as an absorber due to its°at absorption spectrum in the NIR range and water-soluble properties.…”

mentioning

confidence: 99%

Development of a handheld diffuse optical breast cancer assessment probe

Shokoufi

Golnaraghi

2016

J. Innov. Opt. Health Sci.

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Di®use Optical Spectroscopy (DOS) is a promising non-invasive and non-ionizing technique for breast anomaly detection. In this study, we have developed a new handheld DOS probe to measure optical properties of breast tissue. In the proposed probe, the breast tissue is illuminated with four near infrared (NIR) wavelengths light emitting diodes (LED), which are encapsulated in a package (eLEDs), and two PIN photodiodes measure the intensity of the scattered photons at two di®erent locations. The proposed technique of using eLEDs is introduced, in order to have a multi-wavelength pointed-beam illumination source instead of using the laser-coupled¯ber-optic technique, which increases the complexity, size, and cost of the probe. Despite the fact that the proposed technique miniaturizes the probe and reduces the complexity of the DOS, the study proves that it is accurate and reliable in measuring optical properties of the tissue. The measurements are performed at the rate of 10 Hz which is suitable for dynamic measurement of biological activity, in-vivo. The multi-spectral evaluation algorithm is used to reconstruct four main absorber concentrations in the breast including oxy-hemoglobin (cHb), deoxy-hemoglobin (cHbO2), water (cH2O), fat (cFat), and average scattering coe±cient of the medium, as well as concentration changes in Hb (ÁcHb) and HbO2 (ÁcHbO2). Although the probe is designed for breast cancer diagnosis, it can be used in a wide range of applications for both static and dynamic measurements such as functional brain imaging. A series of phantoms, comprised of Delrin r , Intralipid r , Pierce TM and Black ink, are used to verify performance of the device. The probe will be tested on human subjects, in-vivo, in the next phase.

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