Time impact on the antidiabetic effects of key bariatric surgeries: a network meta-analysis of randomized controlled trials with meta-regression

Solé, Thomas; Januel, Léa; Denneval, Axel; Williet, Nicolas; Breton, Christophe; Ollier, Édouard

doi:10.1016/j.soard.2022.02.003

Cited by 6 publications

(1 citation statement)

References 54 publications

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“…The treatment effect of LSG on T2DM in morbidly obese patients was the same compared to laparoscopic RYGB (LRYGB), as demonstrated by a meta-analysis containing 9 studies, in which the remission rates of T2DM were 82.3% and 80.7% for LRYGB and LSG, respectively[ 18 ]. In addition, a meta-analysis containing 33 studies with 4109 patients showed that patients receiving LSG experienced more significant improvement or remission of diabetes than those receiving laparoscopic adjustable gastric banding (LAGB)[ 19 ]. A meta-analysis designed for 1108 adult subjects showed that the probability of T2DM mitigation after LSG was 61.4%, significantly higher than in the medication group (2.5%).…”

Section: Development Of Bariatric/metabolic Surgery and Overview Of P...mentioning

confidence: 99%

State of art on the mechanisms of laparoscopic sleeve gastrectomy in treating type 2 diabetes mellitus

Liu¹,

Wang²,

Guo³

et al. 2023

World J Diabetes

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Obesity and type-2 diabetes mellitus (T2DM) are metabolic disorders. Obesity increases the risk of T2DM, and as obesity is becoming increasingly common, more individuals suffer from T2DM, which poses a considerable burden on health systems. Traditionally, pharmaceutical therapy together with lifestyle changes is used to treat obesity and T2DM to decrease the incidence of comorbidities and all-cause mortality and to increase life expectancy. Bariatric surgery is increasingly replacing other forms of treatment of morbid obesity, especially in patients with refractory obesity, owing to its many benefits including good long-term outcomes and almost no weight regain. The bariatric surgery options have markedly changed recently, and laparoscopic sleeve gastrectomy (LSG) is gradually gaining popularity. LSG has become an effective and safe treatment for type-2 diabetes and morbid obesity, with a high cost-benefit ratio. Here, we review the me-chanism associated with LSG treatment of T2DM, and we discuss clinical studies and animal experiments with regard to gastrointestinal hormones, gut microbiota, bile acids, and adipokines to clarify current treatment modalities for patients with obesity and T2DM.

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Section: Development Of Bariatric/metabolic Surgery and Overview Of P...mentioning

confidence: 99%