Time is ripe: maturation of metabolomics in chronobiology

Rhoades, Seth D.; Sengupta, Arjun; Weljie, Aalim M.

doi:10.1016/j.copbio.2016.09.007

Cited by 17 publications

(25 citation statements)

References 57 publications

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“…In addition, drug‐induced changes in cardiac repolarisation depend on the time of day (Kervezee et al., ). The profound influence of the circadian system on metabolism is supported by metabolomic studies that have shown circadian variation across many classes of metabolites, including amino acids, acylcarnitines and lipids (Chua et al., ; Dallmann, Viola, Tarokh, Cajochen, & Brown, ; Davies et al., ; Giskeodegard, Davies, Revell, Keun, & Skene, ; Rhoades, Sengupta, & Weljie, ). Nevertheless, it should be noted that the relationship between the circadian system and metabolism is bidirectional (Brown, ).…”

Section: Metabolic and Cardiovascular Effects Of Circadian Misalignmementioning

confidence: 99%

Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances

Kervezee

Kosmadopoulos

Boivin

2018

Eur J of Neuroscience

153

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Shift work, defined as work occurring outside typical daytime working hours, is associated with an increased risk of various non‐communicable diseases, including diabetes and cardiovascular disease. Disruption of the internal circadian timing system and concomitant sleep disturbances is thought to play a critical role in the development of these health problems. Indeed, controlled laboratory studies have shown that short‐term circadian misalignment and sleep restriction independently impair physiological processes, including insulin sensitivity, energy expenditure, immune function, blood pressure and cardiac modulation by the autonomous nervous system. If allowed to persist, these acute effects may lead to the development of cardiometabolic diseases in the long term. Here, we discuss the evidence for the contributions of circadian disruption and associated sleep disturbances to the risk of metabolic and cardiovascular health problems in shift workers. Improving the understanding of the physiological mechanisms affected by circadian misalignment and sleep disturbance will contribute to the development and implementation of strategies that prevent or mitigate the cardiometabolic impact of shift work.

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Section: Metabolic and Cardiovascular Effects Of Circadian Misalignmementioning

confidence: 99%

Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances

Kervezee

Kosmadopoulos

Boivin

2018

Eur J of Neuroscience

153

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“…We posit that sleep restriction/deprivation leads to a metabolic setting that could resemble aging and may serve as lead to understand the connection of sleep loss and incident neurodegenerative disorders. Comparison of some recent aging metabolomics studies [47][48][49][50][51][52] and sleep metabolomics studies [61] reveals a striking signature of metabolic similarity. We have analyzed recent aging metabolomics literatures ( Fig.…”

Section: Metabolomics Studies Of Experimental Sleep Deprivationmentioning

confidence: 99%

“…The connection between metabolism and sleep has become increasingly established [61]. For exam- Fig.…”

Section: Metabolomic Investigation Of Sleep and Crossover With Aging mentioning

confidence: 99%

“…ple, sleep promoting small molecules, such as adenosine and melatonin have been extensively studied [62][63][64][65][66]. Recent advances in high throughput metabolomics technologies have resulted in deeper understanding of the link between sleep and metabolism [61]. Although sleep is conserved across evolution and several animal models for sleep study have been developed, metabolomics technologies investigating global metabolic alterations in response to sleep perturbation has been primarily explored in human clinical populations.…”

Section: Metabolomic Investigation Of Sleep and Crossover With Aging mentioning

confidence: 99%

“…We have analyzed recent aging metabolomics literatures ( Fig. 1) and compared biomarkers reported with replicated sleep biomarkers that we have previously analyzed [61]. Five metabolites were replicated across multiple sleep studies and at least one aging study (supplementary information S1).…”

Section: Metabolomics Studies Of Experimental Sleep Deprivationmentioning

confidence: 99%

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Metabolism of sleep and aging: Bridging the gap using metabolomics

Sengupta

Weljie

2019

NHA

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Sleep is a conserved behavior across the evolutionary timescale. Almost all known animal species demonstrate sleep or sleep like states. Despite extensive study, the mechanistic aspects of sleep need are not very well characterized. Sleep appears to be needed to generate resources that are utilized during the active stage/wakefulness as well as clearance of waste products that accumulate during wakefulness. From a metabolic perspective, this means sleep is crucial for anabolic activities. Decrease in anabolism and build-up of harmful catabolic waste products is also a hallmark of aging processes. Through this lens, sleep and aging processes are remarkably parallel-for example behavioral studies demonstrate an interaction between sleep and aging. Changes in sleep behavior affect neurocognitive phenotypes important in aging such as learning and memory, although the underlying connections are largely unknown. Here we draw inspiration from the similar metabolic effects of sleep and aging and posit that large scale metabolic phenotyping, commonly known as metabolomics, can shed light to interleaving effects of sleep, aging and progression of diseases related to aging. In this review, data from recent sleep and aging literature using metabolomics as principal molecular phenotyping methods is collated and compared. The present data suggests that metabolic effects of aging and sleep also demonstrate similarities, particularly in lipid metabolism and amino acid metabolism. Some of these changes also overlap with metabolomic data available from clinical studies of Alzheimer's disease. Together, metabolomic technologies show promise in elucidating interleaving effects of sleep, aging and progression of aging disorders at a molecular level. process of aging is in part the result of progressive decline of physiological function at the molecular level. Key physiological processes impacted by aging include genomic instability, telomere attrition, epigenetic alteration, loss of proteastasis, nutrient sensing dysregulation, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication [3].Along with molecular level changes, behavioral changes are also apparent with healthy aging. Memory impairment [4] and altered sleep wake activities are perhaps the most common signatures of aged individuals [4]. Both human population and rodent model studies have shown that aging individuals are unable to sustain sleep/wake state and generally

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