Time-Lapse Quantitative Computed Tomography Lymphography

Wolf, Gerald; Na, George C.; Gazelle, G. Scott; McIntire, Gregory L.; Cannillo, John; Bacon, Edward R.; Halpern, Elkan F.

doi:10.1016/s1076-6332(12)80009-2

Cited by 15 publications

(9 citation statements)

References 9 publications

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“…The discrepancy between this result and those of previous studies may be due to dierences in experimental method. We injected radiolabeled albumin after gingival massage, while the tracer was injected before (4,6,7) or lymph¯ow was monitored during local massage (5) in the previous studies. Topical massage seems to be eective only during its performance, probably because it may stimulate lymph ow by mechanically pumping tissue¯uid into lymphatic channels.…”

Section: Discussionmentioning

confidence: 99%

Improvement of macromolecular clearance via lymph flow in hamster gingiva by topical warming and massage

Shimotoyodome

Meguro

Hase

et al. 2000

J of Periodontal Research

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The lymphatic system is very important for macromolecular clearance in various tissues, especially in the gingiva. However, the kinetics of macromolecular clearance via the lymph flow in the gingiva are poorly understood. The aim of this study was to investigate whether thermal or mechanical stimulation affects macromolecular clearance via the lymph flow in the gingiva. Carbon black suspension was injected into the mandibular gingiva of anesthetized hamsters and its drainage into cervical lymph nodes was examined. Clearance of 14C-methylated bovine albumin and tritiated water from the gingiva and their drainage into submandibular lymph nodes and blood was quantified. The effect of topical warming or massage on clearance of 14C-methylated albumin from the gingiva during a 15 min period was examined. In addition, the influence of neurochemical antagonists on the stimulatory effect of topical warming on albumin clearance was investigated. Submandibular lymph nodes were clearly delineated by carbon black 10 min after the injection. More radiolabeled albumin appeared in submandibular lymph nodes than in serum, while more tritiated water appeared in serum. Topical warming (45 degrees C, 2 min) and warming plus massage (with a silicon rubber brush, 20 s) decreased the radiolabeled albumin in the gingiva 15 min after the injection. There was less radiolabeled albumin in the gingiva after gingival warming plus massage than after warming. Previous injection of HOE140 or propranolol into the gingiva diminished the stimulatory effect of topical warming on albumin clearance. It was concluded that topical warming plus massage improves macromolecular clearance via the lymph flow in hamster gingiva.

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Section: Discussionmentioning

confidence: 99%

Improvement of macromolecular clearance via lymph flow in hamster gingiva by topical warming and massage

Shimotoyodome

Meguro

Hase

et al. 2000

J of Periodontal Research

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“…Systolic blood pressure was significantly reduced at various time intervals following 20 and 40 mmHg massage in both strains with 40 mmHg yielding a greater reduction in both strains. Wolf et al (1994) investigated the lymphotropic effects of massage by following the transport of nanoparticles using quantitative lymphography. After injection of labeled nanoparticles, the hind-paw was massaged for 9 min and quantitative lymphography of popliteal, presacral, and paraaortic nodes conducted every 10 min.…”

Section: Massagementioning

confidence: 99%

Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review

2020

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Background: Physiological responses related to manual therapy (MT) treatment have been investigated over decades using various animal models. However, these studies have not been compiled and their collective findings appraised. The purpose of this scoping review was to assess current scientific knowledge on the physiological responses related to MT and/or simulated MT procedures in animal models so as to act as a resource to better inform future mechanistic and clinical research incorporating these therapeutic interventions. Methods: PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane, Embase, and Index of Chiropractic Literature (ICL) were searched from database inception to August 2019. Eligible studies were: (a) published in English; (b) non-cadaveric animal-based; (c) original data studies; (d) included a form of MT or simulated MT as treatment; (e) included quantification of at least one delivery parameter of MT treatment; (f) quantification of at least one physiological measure that could potentially contribute to therapeutic mechanisms of action of the MT. MT studies were categorized according to three main intervention types: (1) mobilization; (2) manipulation; and (3) massage. Two-phase screening procedures were conducted by a pair of independent reviewers, data were extracted from eligible studies and qualitatively reported.Results: The literature search resulted in 231 articles of which 78 met inclusion criteria and were sorted by intervention type. Joint mobilization induced changes in nociceptive response and inflammatory profile, gene expression, receptor activation, neurotransmitter release and enzymatic activity. Spinal manipulation produced changes in muscle spindle response, nocifensive reflex response and neuronal activity, electromyography, and immunologic response. Physiological changes associated with massage therapy included autonomic, circulatory, lymphatic and immunologic functions, visceral response, gene expression, neuroanatomy, function and pathology, and cellular response to in vitro simulated massage. Conclusion:Pre-clinical research supports an association between MT physiological response and multiple potential short-term MT therapeutic mechanisms. Optimization Lima et al.Manual Therapy in Animal Models of MT delivery and/or treatment efficacy will require additional preclinical investigation in which MT delivery parameters are controlled and reported using pathological and/or chronic pain models that mimic neuromusculoskeletal conditions for which MT has demonstrated clinical benefit.

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“…Successful opacification of regional draining lymph nodes after subcutaneous injection has been achieved with Pluronic surfactant-stabilized suspensions of insoluble iodinated contrast agents. [3][4][5][6][7][8] Thus Pluronics F68 (group 1) and F108 (group 2) (BASF, Parsippany, NJ) were used as surfactant stabilizers in this work. These surfactants have the same proportions of poly(ethylene oxide) (80%) to poly(propylene oxide) (20%) but at different total molecular weights.…”

Section: Methodsmentioning

confidence: 99%

“…2 Conventional, soluble iodinated X-ray contrast agents do not enhance lymph nodes after parenteral injection due to their rapid extravasation from blood vessels and/or lymphatic vessels. Earlier work has demonstrated the ability of nanoparticles of insoluble, iodinated CT X-ray contrast agents to migrate to regional draining lymph nodes after subcutaneous injection, 3,4 intraperitoneal injection, and peritracheal injection. 5 CT X-ray imaging as early as 1 h postinjection demonstrates excellent enhancement of the regional draining lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

“…5 CT X-ray imaging as early as 1 h postinjection demonstrates excellent enhancement of the regional draining lymph nodes. 4 Animal models have demonstrated the ability of these agents to image meta-static disease as "filling defects" in an otherwise enhanced lymph node. 6,7 Hyperplasia yields a different image upon contrast enhancement such that it is differentiable from metastatic deposits.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary Delivery of Nanoparticles of Insoluble, Iodinated CT x-ray coNtrast Agents to Lung Draining Lymph Nodes in Dogs

McIntire

Bacon

Toner³

et al. 1998

Journal of Pharmaceutical Sciences

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Lung cancer continues to be a leading cause of death around the world. Staging of this disease is critically dependent upon the involvement or noninvolvement of the lymph nodes which drain the region of lung containing the lesion/tumor. Palpation, unenhanced CT, and lymph node excision (i.e., mediastinectomy) are currently used to ascertain the status of these regional draining lymph nodes. The work reported herein details the first efforts toward the pulmonary instillation of iodinated nanoparticles for contrast-enhanced CT of lung draining lymph nodes. The data reflect the impact of dose, time post instillation, and formulation (surfactant) upon the observed CT enhancement of the tracheobronchial lymph nodes of beagle dogs. In addition, initial safety is discussed with both macroscopic and microscopic observations. The results indicate that pulmonary instillation of small volumes of iodinated nanoparticles could be successfully used to aid staging of lung cancer by CT imaging.

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Time-Lapse Quantitative Computed Tomography Lymphography

Cited by 15 publications

References 9 publications

Improvement of macromolecular clearance via lymph flow in hamster gingiva by topical warming and massage

Improvement of macromolecular clearance via lymph flow in hamster gingiva by topical warming and massage

Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review

Pulmonary Delivery of Nanoparticles of Insoluble, Iodinated CT x-ray coNtrast Agents to Lung Draining Lymph Nodes in Dogs

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