Time-of-flight mass spectrometry as a tool for speciation analysis

An Overview of Analytical Applications of Time of Flight-Mass Spectrometric (TOF-MS) Analyzers and an Inductively Coupled Plasma-TOF-MS Technique

“…Exceptional attributes of ICP-TOF-MS, such as high speed of data acquisition, an ability to obtain a full elemental analysis in a time-frame suited to a transient inlet system and significantly better, as compared with widely used quadrupole ICP-MS, the precision of the measurements generate increasing interest in the technique. The ICP-TOF-MS has been successfully coupled to LA, [120][121][122][123][124][125][126] ETV, 127 GC, [128][129][130][131][132] liquid chromatography, 133,134 CE 135,136 and FIA. [137][138][139][140][141] Detailed reviews of the development and analytical performance of TOF-MS combined with ICP ion source have been presented.…”

“…The capabilities of ICP-TOF-MS coupled with CE (and GC) for speciation analysis have been discussed. 136 The advantages of ICP-TOF-MS over sequential mass analyzers for fast transient detection and the simultaneous determination of a large number of isotopes in the flow injection (FI) peaks in trace metal analysis have been discussed. [137][138][139][140][141] The absence of spectral skew is highly appreciated.…”

Speciation of oxidation states of elements by capillary electrophoresis

“…The speciation of inorganic forms of arsenic has been reported in CE systems with detection by proton-induced X-ray emission (PIXE) [48], and by time-of-flight mass spectrometry (TOFMS) [66]. In the first case the appropriate capillary preparation provided PIXE signals for separated HAsO 4 2 -and H 2 AsO 3 -species with similar sensitivity for both analytes in contrast to UV indirect detection, exhibits very different sensitivity for the two separated species.…”

“…In the first case the appropriate capillary preparation provided PIXE signals for separated HAsO 4 2 -and H 2 AsO 3 -species with similar sensitivity for both analytes in contrast to UV indirect detection, exhibits very different sensitivity for the two separated species. In the CE-ICP-TOFMS system As(III) and As(V) were separated as cyanide complexes in polyacrylamidecoated capillary at -30 kV voltage combined with a forward hydrodynamic flow caused by a capillary head pressure [66]. Also, speciation of inorganic arsenic forms only was reported with the use of direct UV detection.…”

Peer Reviewed: Plasma Source TOFMS

“…These devices can monitor the entire mass range of interest continuously and simultaneously (4). TOFMS has also been explored as a method for overcoming some of the limitations of PSMS and is gaining popularity for multielemental and multiisotopic analysis of fast transient signals (5)(6)(7)(8).…”