Time-Pulsed Vacuum and Time-Pulsed Alternating Pressure Chromatography

Abstract

A comparison in separation efficiency between conventional chromatographic methods and newly devised time-pulsed methods (driven by either negative or positive pressure) is made. The methods are compared in terms of adsorbent amounts, solvent volumes, separation efficiency of a binary mixture, and the total time required for separation. It is found that alternating pressure or pulsed methods are superior on all counts compared to the conventional processes. This is supported by discussion of the principles as well as by the provision of detailed parameters for all experiments.