Time resolved diffuse optical spectroscopy with geometrically accurate models for bulk parameter recovery

Guggenheim, James A.; Bargigia, Ilaria; Farina, Andrea; Pifferi, Antonio; Dehghani, Hamid

doi:10.1364/boe.7.003784

Cited by 11 publications

(12 citation statements)

References 23 publications

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“…The curve fitting procedure requires calculation of time-resolved data using a computational model of light propagation for given optical properties in an iterative manner, which as a consequence requires a fast and reliable model for a complex heterogeneous system [15,16].…”

Section: Introductionmentioning

confidence: 99%

Time-resolved near infrared light propagation using frequency domain superposition

Wojtkiewicz¹,

Durdurán²,

Dehghani³

2017

Biomed. Opt. Express

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Time-resolved temporal point spread function (TPSF) measurement of near infrared spectroscopic (NIRS) data allows the estimation of absorption and reduced scattering properties of biological tissues. Such analysis requires an iterative calculation of the theoretical TPSF curve using mathematical and computational models of the domain being imaged which are computationally complex and expensive. In this work, an efficient methodology for representing the TPSF data using a superposition of cosines calculated in frequency domain is presented. The proposed method is outlined and tested on finite element realistic models of the human neck and head. Using an adult head model containing ~140k nodes, the TPSF calculation at each node for one source is accelerated from 3.11 s to 1.29 s within an error limit of ± 5% related to the time domain calculation method. 1957-1975 (1995).

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Section: Introductionmentioning

confidence: 99%

Time-resolved near infrared light propagation using frequency domain superposition

Wojtkiewicz¹,

Durdurán²,

Dehghani³

2017

Biomed. Opt. Express

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“…Guggenheim et al [140] recovered the spectra of µ a (λ) and µ s (λ) of irregularly-shaped homogeneous media from TD-NIRS measurements. The analytical solutions of the TD-DE are usually not applicable to irregularly shaped media, and the finite element method (FEM) was employed to solve the TD-DE.…”

Section: Homogenous Semi-infinite Media or Infinite Slabmentioning

confidence: 99%

“…Sci. 2019, 9, Hybrid TD-RTE and TD-DE [119,120] 2014, 2016 Estimate of tissue composition in breasts using TR reflectance at 7 wavelengths [54,140] Appl. Sci.…”

mentioning

confidence: 99%

“…Sci. 2019, 9, Hybrid TD-RTE and TD-DE [119,120] 2014, 2016 Estimate of tissue composition in breasts using TR reflectance at 7 wavelengths [54,140] The reputation of being cumbersome, bulky, and very expensive has prevented TD-NIRS systems from being used widely in clinical applications, while the theoretical studies of TD-NIRS have antecedently developed many features toward clinical applications.…”

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confidence: 99%

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Time-Domain Near-Infrared Spectroscopy and Imaging: A Review

2019

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This article reviews the past and current statuses of time-domain near-infrared spectroscopy (TD-NIRS) and imaging. Although time-domain technology is not yet widely employed due to its drawbacks of being cumbersome, bulky, and very expensive compared to commercial continuous wave (CW) and frequency-domain (FD) fNIRS systems, TD-NIRS has great advantages over CW and FD systems because time-resolved data measured by TD systems contain the richest information about optical properties inside measured objects. This article focuses on reviewing the theoretical background, advanced theories and methods, instruments, and studies on clinical applications for TD-NIRS including some clinical studies which used TD-NIRS systems. Major events in the development of TD-NIRS and imaging are identified and summarized in chronological tables and figures. Finally, prospects for TD-NIRS in the near future are briefly described.

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“…When the shape of the sample is complex or the accuracy of MC is needed, it is possible to generate a look-up table (LUT) of simulations and apply the inverse problem by searching and/or interpolating results in the LUT [115,116]. This avoids the repetitive computation of MC, which, however, nowadays efficient, could not reach the computation speed of an analytical formula.…”

Section: Final Considerationsmentioning

confidence: 99%

Broadband Time Domain Diffuse Optical Reflectance Spectroscopy: A Review of Systems, Methods, and Applications

et al. 2019

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This review presents recent developments and a wide overview of broadband time domain diffuse optical spectroscopy (TD-DOS). Various topics including physics of photon migration, advanced instrumentation, methods of analysis, applications covering multiple domains (tissue chromophore, in vivo studies, food, wood, pharmaceutical industry) are elaborated. The key role of standardization and recent studies in that direction are discussed. Towards the end, a brief outlook is presented on the current status and future trends in broadband TD-DOS.

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Time resolved diffuse optical spectroscopy with geometrically accurate models for bulk parameter recovery

Cited by 11 publications

References 23 publications

Time-resolved near infrared light propagation using frequency domain superposition

Time-resolved near infrared light propagation using frequency domain superposition

Time-Domain Near-Infrared Spectroscopy and Imaging: A Review

Broadband Time Domain Diffuse Optical Reflectance Spectroscopy: A Review of Systems, Methods, and Applications

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