Time-restricted eating and circadian rhythms: the biological clock is ticking

Queiroz, Jéssica do Nascimento; Macedo, Rodrigo Cauduro Oliveira; Tinsley, Grant M.; Oliveira, Álvaro Reischak de

doi:10.1080/10408398.2020.1789550

Cited by 58 publications

(39 citation statements)

References 82 publications

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“…Time-of-day variations in the benefits of nightly fasting can be explained by fluctuations of the circadian rhythms, which can also vary across chronotypes. The optimal time for food intake might be in the early hours of the day when diet-induced thermogenesis, glucose tolerance, insulin sensitivity, pancreatic beta-cell responsiveness and oxidation of fatty acids are higher [35].…”

Section: Discussionmentioning

confidence: 99%

The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain

et al. 2021

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Nighttime fasting has been inconclusively associated with a reduced risk of cancer. The purpose of this study was to investigate this association in relation to prostate cancer risk. We examined data from 607 prostate cancer cases and 848 population controls who had never worked in night shift work from the Spanish multicase-control (MCC) study, 2008–2013. Through an interview, we collected circadian information on meal timing at mid-age. We estimated odds ratios (OR) and 95% confidence intervals (CI) with unconditional logistic regression. After controlling for time of breakfast, fasting for more than 11 h overnight (the median duration among controls) was associated with a reduced risk of prostate cancer compared to those fasting for 11 h or less (OR = 0.77, 95% 0.54–1.07). Combining a long nighttime fasting and an early breakfast was associated with a lower risk of prostate cancer compared to a short nighttime fasting and a late breakfast (OR = 0.54, 95% CI 0.27–1.04). This study suggests that a prolonged nighttime fasting duration and an early breakfast may be associated with a lower risk of prostate cancer. Findings should be interpreted cautiously and add to growing evidence on the importance of chrononutrition in relation to cancer risk.

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Section: Discussionmentioning

confidence: 99%

The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain

et al. 2021

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“…Moreover, healthy adults with normal weight not aligning TRE to the circadian rhythm (i.e., concentrating food intake to late afternoon or evening) exhibited worsened cardiometabolic outcomes such as elevated FPG and morning glucose intolerance [ 103 ]. Several review articles addressed TRE effects in healthy humans and indicated that this dietary strategy can be beneficial for subjects with cardiometabolic diseases including MetS [ 12 , 18 , 28 , 30 , 33 , 46 , 47 , 76 ].…”

Section: Effects Of Tre In Animals and Healthy Humansmentioning

confidence: 99%

“…In addition, most previous TRE studies of individuals with metabolic disorders included midlife subjects while only a few trials involved young and older individuals [ 38 , 39 , 40 ]. Given a risk of age-related muscle loss, more evidence of TRE effects on nutrient intake, muscle strength and bone mineral density, especially in elderly populations, is desirable [ 46 , 103 , 120 ]. Modulating the gut microbiota through TRE to reverse microbial dysbiosis associated with circadian misalignment may mitigate metabolic risk [ 18 , 114 ], so the effects of TRE on the gut microbiome with potential benefit in MetS warrant further investigation.…”

Section: Knowledge Gaps and Future Perspectives For Tre In Metsmentioning

confidence: 99%

“…Recently, several small-scale clinical studies employing TRE were performed in individuals with metabolic disorders [ 10 , 11 , 16 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. A few recent reviews evaluated the metabolic effects of TRE in both animal and human studies; however, they were not focused exclusively on the populations with MetS [ 18 , 45 , 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

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Time-Restricted Eating and Metabolic Syndrome: Current Status and Future Perspectives

2021

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Metabolic syndrome (MetS) occurs in ~30% of adults and is associated with increased risk of cardiovascular disease and diabetes mellitus. MetS reflects the clustering of individual cardiometabolic risk factors including central obesity, elevated fasting plasma glucose, dyslipidemia, and elevated blood pressure. Erratic eating patterns such as eating over a prolonged period per day and irregular meal timing are common in patients with MetS. Misalignment between daily rhythms of food intake and circadian timing system can contribute to circadian rhythm disruption which results in abnormal metabolic regulation and adversely impacts cardiometabolic health. Novel approaches which aim at restoring robust circadian rhythms through modification of timing and duration of daily eating represent a promising strategy for patients with MetS. Restricting eating period during a day (time-restricted eating, TRE) can aid in mitigating circadian disruption and improving cardiometabolic outcomes. Previous pilot TRE study of patients with MetS showed the feasibility of TRE and improvements in body weight and fat, abdominal obesity, atherogenic lipids, and blood pressure, which were observed despite no overt attempt to change diet quantity and quality or physical activity. The present article aims at giving an overview of TRE human studies of individuals with MetS or its components, summarizing current clinical evidence for improving cardiometabolic health through TRE intervention in these populations, and presenting future perspectives for an implementation of TRE to treat and prevent MetS. Previous TRE trials laid the groundwork and indicate a need for further clinical research including large-scale controlled trials to determine TRE efficacy for reducing long-term cardiometabolic risk, providing tools for sustained lifestyle changes and, ultimately, improving overall health in individuals with MetS.

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“…Several clinical studies as well as studies with animal models were carried out to investigate metabolic disorders [ 14 , 15 , 27 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 ]. Some reviews evaluated the metabolic effects of time-restricted feeding in both animal and human studies; without focusing exclusively on the populations with metabolic syndrome [ 24 , 118 , 119 , 120 ].…”

Section: Association Between Time-restricted Feeding and Normal Circadian Rhythms: A Relevant Approach For The Fight Against Metabolic DImentioning

confidence: 99%

Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock

et al. 2021

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The importance of metabolic health is a major societal concern due to the increasing prevalence of metabolic diseases such as obesity, diabetes, and various cardiovascular diseases. The circadian clock is clearly implicated in the development of these metabolic diseases. Indeed, it regulates physiological processes by hormone modulation, thus helping the body to perform them at the ideal time of day. Since the industrial revolution, the actions and rhythms of everyday life have been modified and are characterized by changes in sleep pattern, work schedules, and eating habits. These modifications have in turn lead to night shift, social jetlag, late-night eating, and meal skipping, a group of customs that causes circadian rhythm disruption and leads to an increase in metabolic risks. Intermittent fasting, especially the time-restricted eating, proposes a solution: restraining the feeding window from 6 to 10 h per day to match it with the circadian clock. This approach seems to improve metabolic health markers and could be a therapeutic solution to fight against metabolic diseases. This review summarizes the importance of matching life habits with circadian rhythms for metabolic health and assesses the advantages and limits of the application of time-restricted fasting with the objective of treating and preventing metabolic diseases.

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Time-restricted eating and circadian rhythms: the biological clock is ticking

Cited by 58 publications

References 82 publications

The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain

The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain

Time-Restricted Eating and Metabolic Syndrome: Current Status and Future Perspectives

Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock

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