Dynamic partial reconfiguration technique can be used to modify regions of an FPGA as large as the whole reconfigurable fabric or as small as individual logic elements. However, FPGA manufacturers have focused their efforts on designing tools that support the design of monolithic reconfigurable accelerators spanning large regions of the device. Nevertheless, in some applications, it is enough to fine-tune the accelerators' behavior instead of changing them entirely. In these cases, rather than allocating new accelerators, it is possible to reconfigure individual logic elements of the circuit, such as look-up tables or flip-flops. There is also an intermediate approach that targets the reconfigurability of accelerators composed of several tightly interconnected modules, such as overlays. In those architectures, it is possible to reconfigure only the modules that differ between the existing accelerator versions, thus reducing the reconfigurable footprint granularity. This paper proposes a classification of the approaches above, categorizing them as coarse, fine, and medium grain, respectively. There are neither commercial nor academic tools supporting multi-grain reconfiguration to take advantage of each granularity strength on commercial FPGAs. Differently, this paper proposes a tool called IMPRESS, that provides design-time and run-time support for multi-grain reconfiguration in Xilinx 7 Series FPGAs. Specific criteria are provided to combine the different granularity levels, trading off the benefits in terms of flexibility and performance, with different design and run-time costs. Two use cases in the image processing and neural network domains have been implemented to show how IMPRESS can build multi-grain reconfigurable systems.