Time to first defibrillation and survival outcomes of out-of-hospital cardiac arrest with refractory ventricular fibrillation

Time to amiodarone administration and survival outcomes in refractory ventricular fibrillation

“…For OHCA interventions broadly, studies have consistently showed a negative association exists between time to intervention and subsequent outcome, with earlier administration associated with better survival 7–9 . However, such literature regarding the administration time of antiarrhythmic agents remains scarce.…”

Cardiac arrest: An interdisciplinary scoping review of clinical literature from 2020

“…[11][12][13][14][15][16][17][18][19][20] Endpoints included time elapsed until recognition of cardiac arrest, contact with first responders, defibrillation, establishment of vascular access, epinephrine administration, resumption of chest compressions after pulse check, and definitive care in a hospital. [11][12][13][14][15][16][17][18][19][20] Overall, although a reduced time to each intervention during resuscitation was not uniformly shown to improve survival or neurologic outcome, no harms from more rapid intervention for each of the parameters listed above were noted. Moreover, delays in arrival or in initiation of a given therapy continued to demonstrate increased odds of poor outcomes as measured by cerebral performance category (CPC).…”

Are there disparities in the location of automated external defibrillators in England?

“…2 Early defibrillation is an essential element of the chain of survival and prompt treatment with a defibrillator, within 3-5 min of collapse, can lead to survival rates in excess of 50%. [3][4][5][6][7] As time passes, the effectiveness of defibrillation declines and the likelihood of survival decreases, as the heart rhythm degenerates from a shockable rhythm to a non-shockable rhythm, which is largely unresponsive to treatment. Each minute of delay of defibrillation reduces the probability of survival to discharge by 10%.…”

“…, 6. , 7. As time passes, the effectiveness of defibrillation declines and the likelihood of survival decreases, as the heart rhythm degenerates from a shockable rhythm to a non-shockable rhythm, which is largely unresponsive to treatment.…”