2018
DOI: 10.1016/j.cotox.2018.02.003
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Time to get personal: A framework for personalized targeting of oxidative stress in neurotoxicity and neurodegenerative disease

Abstract: The annual cost for neurological disorders in the United States was $789 billion in 2014, and with an aging population these numbers are expected to significantly increase in the next 50 years [1]. Neurodegenerative diseases make up a significant portion of these costs. Neurodegenerative diseases are characterized by the loss of neuronal populations in specific regions of the brain. Although the cause is still unknown for most of these diseases, both genetic and environmental factors are thought to play import… Show more

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Cited by 20 publications
(6 citation statements)
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“…Estas características son otorgadas por algunos de los metabolitos secundarios antes mencionados, producidos por estas frutas como mecanismo de protección frente a radiación y baja temperatura (5,6). En diversos estudios se ha determinado que dichos compuestos brindan beneficios claros en nuestra salud, ya que tienen la capacidad de evitar el estrés oxidativo (7).…”
Section: Introductionunclassified
“…Estas características son otorgadas por algunos de los metabolitos secundarios antes mencionados, producidos por estas frutas como mecanismo de protección frente a radiación y baja temperatura (5,6). En diversos estudios se ha determinado que dichos compuestos brindan beneficios claros en nuestra salud, ya que tienen la capacidad de evitar el estrés oxidativo (7).…”
Section: Introductionunclassified
“…The structures of compounds 1-9 (▶ Fig. 1) were identified by means of spectral analysis, and determined as notoginsenoside R 1 (1), notoginsenoside R 2 (2), ginsenoside Rh 1 (3), protopanaxatriol (4), ginsenoside Rg 1 (5), ginsenoside Rg 2 (6), ginsenoside U (7), pseudoginsenoside RT 3 (8), and 6-O-(β-D-glucopyranosyl)-20-O-(β-D-xylopyranosyl)-3β,6α,12β,20(S)-tetrahydroxydammar-24-ene (9). The detailed data and references are shown in the Supporting Information.…”
Section: Resultsmentioning
confidence: 99%
“…However, physiological concentrations of free radicals play an important role in normal brain function (De Silva and Miller, 2016;Scialò et al, 2017;Chen et al, 2018). Thus, ROS can contribute to: vascularization, cerebral perfusion, cellular signaling, synaptic plasticity, neurotransmitter secretion and cerebral vasodilation (Massaad and Klann, 2011;Grochowski et al, 2018;Neal and Richardson, 2018). A moderate increase of ROS secondary to mitochondrial activity produces preconditioning that leads to a neuroprotective function against harmful agents and is even preventive against massive ROS formation (Dirnagl and Meisel, 2008;Jou, 2008;Dirnagl et al, 2009).…”
Section: Oxidative Stress and Neurodegenerative Diseasesmentioning
confidence: 99%