Time to local recurrence as a predictor of survival in unrecetable gastric cancer patients after radical gastrectomy

Li, Hui; Jin, Xuesong; Liu, Peng; Hong, Wei

doi:10.18632/oncotarget.19038

Cited by 10 publications

(17 citation statements)

References 27 publications

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“…Thus, tumor local relapse remains one of the major problems in managing STS, and can be defined as early or late recurrence. In breast adenocarcinoma, renal cell carcinoma, and gastric cancer, it was previously reported that patients with late recurrence had better prognosis than those with early recurrence ( 4 – 6 ). However, to the best of our knowledge, neither significant factors affecting the survival after recurrence (SAR) for STS patients nor information concerning the prognostic significance of time to local recurrence (TLR) in STS patients have been reported.…”

Section: Introductionmentioning

confidence: 99%

Time to Local Recurrence as a Predictor of Survival in Patients With Soft Tissue Sarcoma of the Extremity and Abdominothoracic Wall

et al. 2020

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Objective The purpose of this retrospective study was to identify the prognostic significance of time to local recurrence (TLR) with regard to overall survival (OS) and survival after local recurrence (SAR) in patients with soft tissue sarcoma (STS) of the extremity and abdominothoracic wall. Methods We identified 477 patients who underwent R0 resection for localized STS of the extremity and abdominothoracic wall, from January 1995 to December 2016, of whom 190 patients developed local recurrence as their first recurrent event. Based on TLR, patients were divided into two groups: early local recurrence (ELR, <12 months) and late local recurrence (LLR, ≥12 months). The Kaplan–Meier method and Cox regression analysis were used to estimate the OS and SAR, and to identify factors associated with patient outcomes. Results The median follow-up time for the entire cohort was 118.4 months, and was 118.5 months for the 190 patients who developed local recurrence. Deep tumor location (HR 1.73, 95% CI 1.27–2.37, P = 0.001) and tumor grade ≥2 (G2 vs. G1: HR 1.75, 95% CI 1.21–2.53, G3 vs. G1: HR 2.57, 95% CI 1.66–3.98, P < 0.001) were associated with a higher rate of local recurrence. There were 99 patients in the ELR group and 91 in the LLR group, with a median TLR of 10.8 months for the entire cohort. Patients from the ELR group had a shorter OS and a lower 5-year OS rate than the LLR group. Univariate and multivariate analyses demonstrated TLR as an independent prognostic factor for SAR and OS, in addition to tumor grade. Also, surgical treatment and absence of metastasis after local recurrence were associated with longer SAR. Conclusions In patients with STS of the extremity and abdominothoracic wall, ELR after R0 resection indicated a worse prognosis than those with LLR, and TLR can be considered an independent prognostic factor for OS and SAR. Furthermore, local recurrence was significantly influenced by the depth and the histopathological grading of the primary tumor, and reoperation after local recurrence could improve survival, which means salvage surgery may still be the preferred treatment when there are surgical indications after recurrence.

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Section: Introductionmentioning

confidence: 99%

Time to Local Recurrence as a Predictor of Survival in Patients With Soft Tissue Sarcoma of the Extremity and Abdominothoracic Wall

et al. 2020

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“…It has been reported that patients with late recurrence had better survival than those with early recurrence among those with rectal cancer, renal cell carcinoma and gastric cancer. [10][11][12] In cutaneous melanoma, despite several publications investigating the prognostic impact of TTR, the results remain controversial.…”

Section: Discussionmentioning

confidence: 99%

“…However, in patients with cancers such as rectal cancer, renal cell carcinoma or gastric cancer, patients with early TTR were reported to have worse outcomes than those with late TTR. 10 , 11 , 12 On the other hand, survival after recurrence (SAR) is an optimal study endpoint in malignancies with a high prevalence of recurrence, but the prognostic predictors of SAR in cutaneous melanoma have not been well discussed. Such knowledge is, however, valuable for assessing post‐recurrence risk stratification and guiding the appropriate follow‐up schedule.…”

Section: Introductionmentioning

confidence: 99%

Early time to recurrence predicts worse survival in patients with localized or regionally advanced cutaneous melanoma

Liang

et al. 2021

Dermatologic Therapy

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To investigate the prognostic significance of time to recurrence (TTR) for overall survival (OS) and survival after recurrence (SAR) in patients with localized or regionally advanced cutaneous melanoma. A total of 731 cutaneous melanoma patients with an initial diagnosis of 8th American Joint Committee on Cancer (AJCC) clinical stage I-III were included in this study. The prognostic factors associated with OS and SAR were estimated through Kaplan-Meier and Cox regression analysis. Of the total cohort, 329 patients (45%) died, and 418 patients (57%) experienced recurrence. The median follow-up and TTR were 55.6 months and 9.6 months, respectively. A total of 141 patients (19%) experienced recurrence in <6 months, and 277 patients (38%) experienced recurrence in ≥6 months. Patients with stage III and positive lymph node dissection (LND) were more common in the early TTR group than in the late TTR group. Both the OS and SAR rates at 5 years and 10 years in the early TTR group were significantly poorer than those in the late TTR group (P < .001 and P = .008, respectively). Furthermore, early TTR, along with truncal tumor, higher TNM stage and therapeutic variables (extended resection, LND and adjuvant therapy), were significant independent predictors of worse OS and SAR in multivariate analysis (all P < .05). Early TTR predicts worse survival and could be considered an independent prognostic factor for patients with localized or regionally advanced cutaneous melanoma. TTR should be evaluated in all patients with recurrence to guide postrecurrence risk stratification and follow-up schedules.

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“…It was suggested that early recurrence indicated a dismal prognosis and death risk was twofold higher than those GC patients with late recurrence. 28 These early recurrence-related clinicopathological features might be available for predicting prognosis of GC patients.…”

Section: F I G U R Ementioning

confidence: 99%

Patterns of recurrence after curative D2 resection for gastric cancer: Implications for postoperative radiotherapy

Шен

Shui

et al. 2020

Cancer Medicine

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Time to local recurrence as a predictor of survival in unrecetable gastric cancer patients after radical gastrectomy

Cited by 10 publications

References 27 publications

Time to Local Recurrence as a Predictor of Survival in Patients With Soft Tissue Sarcoma of the Extremity and Abdominothoracic Wall

Time to Local Recurrence as a Predictor of Survival in Patients With Soft Tissue Sarcoma of the Extremity and Abdominothoracic Wall

Early time to recurrence predicts worse survival in patients with localized or regionally advanced cutaneous melanoma

Patterns of recurrence after curative D2 resection for gastric cancer: Implications for postoperative radiotherapy

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