2005
DOI: 10.1086/432472
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Time to Positivity in Staphylococcus aureus Bacteremia: Possible Correlation with the Source and Outcome of Infection

Abstract: Time to positivity in S. aureus bacteremia may provide useful diagnostic and prognostic information. Growth of S. aureus within 14 h after the initiation of incubation may identify patients with a high likelihood of endovascular infection sources, delayed clearance, and complications.

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Cited by 126 publications
(114 citation statements)
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“…Microbiological characteristics like capability of biofilm production, quantitative blood cultures, the proportion of positive blood cultures or the time to positivity of blood cultures has been suggested to be discriminative in this setting [4,9,13]. In Staphylococcus aureus, the time to positivity of blood cultures provided useful diagnostic and prognostic information; growth within 12-14 h after the initiation of incubation identified patients with a high likelihood of endovascular infection sources, delayed bacterial clearance and septic complications [14]. However, the time delay of several days and the financial cost are major disadvantages of this approach.…”
Section: Discussionmentioning
confidence: 99%
“…Microbiological characteristics like capability of biofilm production, quantitative blood cultures, the proportion of positive blood cultures or the time to positivity of blood cultures has been suggested to be discriminative in this setting [4,9,13]. In Staphylococcus aureus, the time to positivity of blood cultures provided useful diagnostic and prognostic information; growth within 12-14 h after the initiation of incubation identified patients with a high likelihood of endovascular infection sources, delayed bacterial clearance and septic complications [14]. However, the time delay of several days and the financial cost are major disadvantages of this approach.…”
Section: Discussionmentioning
confidence: 99%
“…Time to positivity of the blood culture was defined as the time between the start of incubation and the time that the automated alert signal indicating growth in the culture bottle sounded [11,12]. In case of multiple positive blood cultures inoculated within maximum two hours, the shortest TTP was taken into account [1,3] SAB was considered as community-acquired if it occurred within 48 h after admission and as nosocomial thereafter [14].…”
Section: Definitionsmentioning
confidence: 99%
“…The higher the initial bacterial inoculum, the quicker the cut-off value for detection of positivity is reached [1,2]. TTP is an indirect marker of the bacterial load and is associated with a higher morbidity and mortality [3]. Differential TTP is used for the diagnosis of catheterrelated bacteremia [2,4,[5][6][7] and TTP is used for predicting the presence of Staphylococcus spp.…”
Section: Introductionmentioning
confidence: 99%
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“…[6][7][8][9] Complications are often occult and, as it is not practical to investigate every case of S. aureus bacteraemia extensively, clinicians have attempted to identify factors that predict their subsequent development (Table 1). 10,11 However, no risk factor or constellation of risk factors will reliably identify all individuals with -or who will develop -complications.…”
Section: Complicationsmentioning
confidence: 99%