Time to pregnancy among Danish laboratory technicians who were a part of the National Birth Cohort

Knudsen, Lisbeth E.; Andersen, Anne‐Marie Nybo; Hjøllund, Niels Henrik; Olsen, Jørn

doi:10.5271/sjweh.857

Cited by 9 publications

(9 citation statements)

References 25 publications

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“…12 18 In addition, the monitoring data on the radioisotopes from the National Institute of Radiation Hygiene did not show excess exposure for the laboratory workers who were at potential risk of exposure to radioisotopes. 19 No conclusion has been reached Cox regression for fetal loss and congenital malformations, HR: hazard ratio; logistic regression for other outcomes, OR: odds ratio; CI: confidence interval; adjusted for maternal age, gravidity, history of spontaneous abortion, prepregnancy body mass index, smoking, alcohol consumption, and paternal job (as well as sex of child for preterm, very preterm birth, and congenital malformations). *Among live births.…”

Section: Discussionmentioning

confidence: 99%

“…19 22 23 The exposure matrix was adjusted to the present work situation, but it does not include the levels of workers' applied protection, and the validity of the exposure matrix has not been tested in a separate exposure study. The results for specific exposures to substances must thus be interpreted with caution.…”

Section: Discussionmentioning

confidence: 99%

“…*An exposure index (EI) for each exposure was calculated as follows: EI = EL6F, where EL = exposure level (see Zhu et al 19 ), low = 1, medium = 2, and high = 3; F = frequency of work contacts, every day = 4, several times per week = 3, several days per month = 2, and more rare = 1. It was then grouped into 1-5 and 6+.…”

Section: Discussionmentioning

confidence: 99%

“…The questions on laboratory work, together with a job exposure matrix, were similar to a previous Danish survey of industrial technicians in 1980. 22 23 The exposure quantification in the job exposure matrix 19 was adjusted to the present working situation according to the experience of present laboratory work by two authors of the study with the exposure matrix. 22 We used an exposure index (EI) for each exposure, which was calculated as follows: EI = EL6F, where EL = exposure level (based on the job exposure matrix 19 ), low = 1, medium = 2, and high = 3; F = frequency of work contacts, every day = 4, several times per week = 3, several days per month = 2, and more rare = 1.…”

Section: Exposure Assessmentmentioning

confidence: 99%

“…2 11 Previously we found no significant differences in time to pregnancy among women performing different work tasks in laboratory. 19 In this study we used a follow up study design to examine whether exposure to laboratory work tasks or exposure to substances assessed by a job exposure matrix had an increased risk of preterm birth, small for gestational age, or congenital malformations.…”

mentioning

confidence: 99%

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Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark

Zhu

Knudsen²,

Andersen³

et al. 2005

Occup Environ Med

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Aims: To examine pregnancy outcomes in women doing laboratory work. Methods: Using data from the Danish National Birth Cohort (1997Cohort ( -2003, the authors conducted a prospective cohort study of 1025 female laboratory technicians and 8037 female teachers (as reference). The laboratory technicians were asked about laboratory work tasks during pregnancy in an interview (at around 16 weeks of gestation). Pregnancy outcomes were obtained by linking the cohort to the national registers. Hazard ratios (HRs) of late fetal loss and diagnosing of congenital malformations were calculated by using Cox regression, and odds ratios (ORs) of preterm birth and small for gestational age were calculated by using logistic regression. Results: Overall, there were no significant differences in pregnancy outcomes between laboratory technicians and teachers. However, we found that laboratory technicians working with radioimmunoassay or radiolabelling had an increased risk of preterm birth (OR = 2.2, 95% CI 0.8 to 6.2 for radioimmunoassay, and OR = 1.9, 95% CI 0.8 to 4.6 for radiolabelling) and ''major'' malformations (HR = 2.1, 95% CI 1.0 to 4.7 for radioimmunoassay, and HR = 1.8, 95% CI 0.9 to 3.7 for radiolabelling). The ORs of preterm birth doubled for women working with these tasks every day or several times a week. When an exposure matrix was applied, an increased risk of ''major'' malformations for exposure to organic solvents was seen. Conclusions:The results did not indicate any high risk of reproductive failures in laboratory technicians in general. Exposure to radioisotopes may carry a high risk of preterm birth and congenital malformations. This finding deserves further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Exposure Assessmentmentioning

confidence: 99%

mentioning

confidence: 99%

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Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark

Zhu

Knudsen²,

Andersen³

et al. 2005

Occup Environ Med

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Indoor and outdoor air pollution and couple fecundability: a systematic review

Siegel

Ghassabian

Hipwell

et al. 2022

Human Reproduction Update

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BACKGROUND Air pollution is both a sensory blight and a threat to human health. Inhaled environmental pollutants can be naturally occurring or human-made, and include traffic-related air pollution (TRAP), ozone, particulate matter (PM) and volatile organic compounds, among other substances, including those from secondhand smoking. Studies of air pollution on reproductive and endocrine systems have reported associations of TRAP, secondhand smoke (SHS), organic solvents and biomass fueled-cooking with adverse birth outcomes. While some evidence suggests that air pollution contributes to infertility, the extant literature is mixed, and varying effects of pollutants have been reported. OBJECTIVE AND RATIONALE Although some reviews have studied the association between common outdoor air pollutants and time to pregnancy (TTP), there are no comprehensive reviews that also include exposure to indoor inhaled pollutants, such as airborne occupational toxicants and SHS. The current systematic review summarizes the strength of evidence for associations of outdoor air pollution, SHS and indoor inhaled air pollution with couple fecundability and identifies gaps and limitations in the literature to inform policy decisions and future research. SEARCH METHODS We performed an electronic search of six databases for original research articles in English published since 1990 on TTP or fecundability and a number of chemicals in the context of air pollution, inhalation and aerosolization. Standardized forms for screening, data extraction and study quality were developed using DistillerSR software and completed in duplicate. We used the Newcastle-Ottawa Scale to assess risk of bias and devised additional quality metrics based on specific methodological features of both air pollution and fecundability studies. OUTCOMES The search returned 5200 articles, 4994 of which were excluded at the level of title and abstract screening. After full-text screening, 35 papers remained for data extraction and synthesis. An additional 3 papers were identified independently that fit criteria, and 5 papers involving multiple routes of exposure were removed, yielding 33 articles from 28 studies for analysis. There were 8 papers that examined outdoor air quality, while 6 papers examined SHS exposure and 19 papers examined indoor air quality. The results indicated an association between outdoor air pollution and reduced fecundability, including TRAP and specifically nitrogen oxides and PM with a diameter of ≤2.5 µm, as well as exposure to SHS and formaldehyde. However, exposure windows differed greatly between studies as did the method of exposure assessment. There was little evidence that exposure to volatile solvents is associated with reduced fecundability. WIDER IMPLICATIONS The evidence suggests that exposure to outdoor air pollutants, SHS and some occupational inhaled pollutants may reduce fecundability. Future studies of SHS should use indoor air monitors and biomarkers to improve exposure assessment. Air monitors that capture real-time exposure can provide valuable insight about the role of indoor air pollution and are helpful in assessing the short-term acute effects of pollutants on TTP.

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Occupational exposure to chemical substances and time to pregnancy: a systematic review

Snijder

Velde

Roeleveld

et al. 2012

Human Reproduction Update

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Time to pregnancy among Danish laboratory technicians who were a part of the National Birth Cohort

Cited by 9 publications

References 25 publications

Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark

Laboratory work and pregnancy outcomes: a study within the National Birth Cohort in Denmark

Indoor and outdoor air pollution and couple fecundability: a systematic review

Occupational exposure to chemical substances and time to pregnancy: a systematic review

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