Time to rejuvenate ultra-low dose whole-body radiotherapy of cancer

Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice

“…Apparently, some in vivo factors were induced by the lower-dose irradiations, which more effectively than the higher-dose exposures, suppressed the potential of the tumor cells to grow in vitro and in vivo. This notion is supported by multiple observations that exposures to low-LET radiation at ≤0.1 Gy per fraction more potently suppresses cancer growth in experimental animals and human patients than do irradiations at higher daily doses (reviewed in [8,9]) Generally, these results corroborate the findings from our earlier experiments conducted in both C57BL/6 and the more radiosensitive BALB/c mice exposed to both single and multiple WBIs with X-rays at 0.1 and 0.2 Gy and assayed for the development of the induced neoplastic colonies in the lungs [49][50][51][52]. In fact, the present results expand our previous observations in that the anti-tumor effects were expressed not only after i.v., but also after o.t.…”

“…In contrast to local irradiations of the tumor with doses in the range of 1-2 Gy per fraction, exposures of the whole body of patients at low doses, i.e., not exceeding 0.1-0.2 Gy per fraction [7], do not kill or injure normal cells and are devoid of such adverse effects of the high-dose irradiations as inflammation, immunosuppression, and secondary cancers (reviewed in [8,9]). Indeed, as evidenced by the results of numerous animal studies including our own (reviewed in [8]) and, especially, of more than forty reliable clinical trials performed since the early 1930s having documented that fractionated whole-body irradiations (WBI) improve long-term overall survival and cure rates in patients with advanced hematological and solid neoplasms (reviewed in [9]). Arguably, a crucial underlying mechanism of such effects is up-regulation of the function of the immune system, the organism's most important guardian against cancer (reviewed in [8,10,11]).…”

Mesenchymal Stem Cells and Selenium Nanoparticles Synergize with Low Dose of Gamma Radiation to Suppress Mammary Gland Carcinogenesis via Regulation of Tumor Microenvironment

“…Group (7) DMBA + MSCs: rats were injected with DMBA as group (2); then, they were treated with MSC similar to group (4). Group (8) DMBA + LDRR: rats were injected with DMBA as group (2); then, they were exposed to γ-radiation as group (5). Group (9) DMBA + MSCs + SeNPs + LDR: rats were injected with DMBA as group (2); then, they were exposed to LDR as group ( 5) and treated with SeNPs as group (3), after that they were treated with MSC as group (4).…”

Treatment of Early-Stage Alzheimer’s Disease With CT Scans of the Brain: A Case Report

“…Numerous publications have shown that low-dose radiation has been historically successful in the treatment of many diseases and other conditions with an inflammatory foundation. 2 - 5 Since it had been established that low-dose radiation could reliably mitigate inflammation and facilitate healing by the polarization of macrophages from the M1 phenotype to the anti-inflammatory M2 phenotype in a wide range of tissues, this has been suggested as the underlying mechanism for these reported historical successes. 2 , 6 There is also a substantial animal model literature that supports these clinical observations.…”

“…A case report was submitted to a journal and published in April 2016. 3 Ongoing booster treatments and information updates on her improved quality of life continued until she died on May 18, 2018. 11 , 12 …”