2019
DOI: 10.1096/fj.201900179rr
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Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

Abstract: Although the role of the Hippo signaling pathway in development and tumorigenesis has been extensively studied in multiple organs, its role in ovarian follicle development remains largely unknown. Here, we report that Yes‐Associated Protein 1 (YAP1), the major effector of Hippo signaling, is spatiotemporally expressed in ovarian granulosa cells and plays a critical role in the regulation of follicle development. We found that the active form of YAP1 (nuclear YAP1) was predominantly expressed in proliferative g… Show more

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Cited by 88 publications
(86 citation statements)
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“…The reciprocal effect, manifested by a reduced number of primordial follicles and elevation in secondary follicles, is obtained upon YAP1 overexpression [ 47 , 52 ]. These findings are supported by another study, in which a specific deletion of YAP1 in GCs of primordial follicles resulted in subfertility which was subsequent to increased cell apoptosis, reduced number of CL and a decline in ovarian size [ 48 ]. Taken together these studies suggest that YAP1 mainly induces the transition of follicles from the primordial to the primary stage.…”
Section: Novel Regulators Of Fulliculogenesissupporting
confidence: 64%
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“…The reciprocal effect, manifested by a reduced number of primordial follicles and elevation in secondary follicles, is obtained upon YAP1 overexpression [ 47 , 52 ]. These findings are supported by another study, in which a specific deletion of YAP1 in GCs of primordial follicles resulted in subfertility which was subsequent to increased cell apoptosis, reduced number of CL and a decline in ovarian size [ 48 ]. Taken together these studies suggest that YAP1 mainly induces the transition of follicles from the primordial to the primary stage.…”
Section: Novel Regulators Of Fulliculogenesissupporting
confidence: 64%
“…The phosphorylated YAP1 and WWTR1 are sequestered to the cytoplasm, and their action as transcriptional co-activators is prevented [ 45 , 46 ]. In the ovaries, YAP1 is localized in the cytoplasm of GC of primordial and secondary follicles [ 47 , 48 ]. Follicular development in the ovary is accompanied by a reduction in MST1 and LATS2 and elevation in YAP1 expression, accompanied by a decrease in MST1 phosphorylation, indicating its inactivation [ 47 ].…”
Section: Novel Regulators Of Fulliculogenesismentioning
confidence: 99%
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“…In addition, Yes-associated protein (YAP1) is the main effector of the Hippo pathway and contributes to the development of many cancers. 21 EMT exerts a crucial role in tumor metastasis. 22 Activation of the extracellular signal-regulated kinase (ERK) signaling pathway contributes to EMT in lung cancer.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, Yes‐associated protein (YAP1) is the main effector of the Hippo pathway and contributes to the development of many cancers . EMT exerts a crucial role in tumor metastasis .…”
Section: Introductionmentioning
confidence: 99%