Timing- and Dose-Specific Associations of Prenatal Smoke Exposure With Newborn DNA Methylation

Monasso, Giulietta S; Jaddoe, Vincent W. V.; Jongste, Johan C. de; Duijts, Liesbeth; Felix, Janine F.

doi:10.1093/ntr/ntaa069

Cited by 7 publications

(8 citation statements)

References 21 publications

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Section: Description Of Epigenetic Regulation Mechanismsmentioning

confidence: 99%

“…Whereas a dose–response relationship was underlined by several studies (the more pregnant women smoked, the greater were changes in DNA methylation) [ 86 , 103 ], a recent study suggests that any exposure to tobacco smoke during pregnancy could be harmful toward infant lung function [ 99 ]. Monasso et al [ 86 ] and Rousseaux et al [ 97 ] explored different timing of exposure around pregnancy. In cord blood, Monasso et al identified 1391 CpGs differentially methylated in sustained (but not in women quitting smoking prior or in early pregnancy) vs. never smokers, among 5915 CpGs established with robust evidence for association with sustained maternal smoking in a prior meta-analysis [ 76 ].…”

Section: Description Of Epigenetic Regulation Mechanismsmentioning

confidence: 99%

“…In cord blood, Monasso et al identified 1391 CpGs differentially methylated in sustained (but not in women quitting smoking prior or in early pregnancy) vs. never smokers, among 5915 CpGs established with robust evidence for association with sustained maternal smoking in a prior meta-analysis [ 76 ]. They concluded that quitting smoking during pregnancy might be associated with DNA methylation at other CpGs [ 86 ]. In accordance with these conclusions, the results of the EWAS performed by Rousseaux et al on former, current, and non-smokers during pregnancy identified specific CpGs/DMRs in the placenta associated with these smoking statuses, suggesting the establishment of a memory of exposure to tobacco affecting the methylation pattern of placentas that had never been directly exposed to smoking [ 97 ].…”

Section: Description Of Epigenetic Regulation Mechanismsmentioning

confidence: 99%

“…In epigenetic epidemiology applied to the DOHaD, maternal smoking is one of the exposures that has been the most widely investigated. A growing number of studies have characterized the associations between maternal tobacco smoking during pregnancy and epigenetic mechanisms [ 19 , 21 , 36 , 51 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 ], using different methodological approaches and different tissues (including placental, cord blood, blood, etc.). Most studies rely on DNA methylation, which is the best understood and the most cost-effective epigenetic mark to consider in epidemiological studies, and it is conduc...…”

Section: Introductionmentioning

confidence: 99%

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Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review

Nakamura

Ochsenbein

Lepeule

2021

IJERPH

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In utero exposure to maternal tobacco smoking is the leading cause of birth complications in addition to being associated with later impairment in child’s development. Epigenetic alterations, such as DNA methylation (DNAm), miRNAs expression, and histone modifications, belong to possible underlying mechanisms linking maternal tobacco smoking during pregnancy and adverse birth outcomes and later child’s development. The aims of this review were to provide an update on (1) the main results of epidemiological studies on the impact of in utero exposure to maternal tobacco smoking on epigenetic mechanisms, and (2) the technical issues and methods used in such studies. In contrast with miRNA and histone modifications, DNAm has been the most extensively studied epigenetic mechanism with regard to in utero exposure to maternal tobacco smoking. Most studies relied on cord blood and children’s blood, but placenta is increasingly recognized as a powerful tool, especially for markers of pregnancy exposures. Some recent studies suggest reversibility in DNAm in certain genomic regions as well as memory of smoking exposure in DNAm in other regions, upon smoking cessation before or during pregnancy. Furthermore, reversibility could be more pronounced in miRNA expression compared to DNAm. Increasing evidence based on longitudinal data shows that maternal smoking-associated DNAm changes persist during childhood. In this review, we also discuss some issues related to cell heterogeneity as well as downstream statistical analyses used to relate maternal tobacco smoking during pregnancy and epigenetics. The epigenetic effects of maternal smoking during pregnancy have been among the most widely investigated in the epigenetic epidemiology field. However, there are still huge gaps to fill in, including on the impact on miRNA expression and histone modifications to get a better view of the whole epigenetic machinery. The consistency of maternal tobacco smoking effects across epigenetic marks and across tissues will also provide crucial information for future studies. Advancement in bioinformatic and biostatistics approaches is key to develop a comprehensive analysis of these biological systems.

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Section: Description Of Epigenetic Regulation Mechanismsmentioning

confidence: 99%

Section: Description Of Epigenetic Regulation Mechanismsmentioning

confidence: 99%

Section: Description Of Epigenetic Regulation Mechanismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review

Nakamura

Ochsenbein

Lepeule

2021

IJERPH

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“…Some of these changes persisted at 7 years and 17 years of age in offspring [ 50 ]. A study from the Generation R cohort found that changes in cord blood DNAm at 1391 CpGs was related to continued maternal smoking during pregnancy, whereas quitting smoking early in pregnancy and paternal smoking were not associated with DNAm changes at 5915 CpGs known to be related to maternal smoking [ 51 ].…”

Section: Dnam As a Potential Epigenetic Mechanism Linking Smoke Exposure Or Prenatal Stress To Childhood Respiratory Health Outcomesmentioning

confidence: 99%

Exposure to Stress and Air Pollution from Bushfires during Pregnancy: Could Epigenetic Changes Explain Effects on the Offspring?

Murphy

Karmaus

Mattes

et al. 2021

IJERPH

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Due to climate change, bushfires are becoming a more frequent and more severe phenomenon which contributes to poor health effects associated with air pollution. In pregnancy, environmental exposures can have lifelong consequences for the fetus, but little is known about these consequences in the context of bushfire smoke exposure. In this review we summarise the current knowledge in this area, and propose a potential mechanism linking bushfire smoke exposure in utero to poor perinatal and respiratory outcomes in the offspring. Bushfire smoke exposure is associated with poor pregnancy outcomes including reduced birth weight and an increased risk of prematurity. Some publications have outlined the adverse health effects on young children, particularly in relation to emergency department presentations and hospital admissions for respiratory problems, but there are no studies in children who were exposed to bushfire smoke in utero. Prenatal stress is likely to occur as a result of catastrophic bushfire events, and stress is known to be associated with poor perinatal and respiratory outcomes. Changes to DNA methylation are potential epigenetic mechanisms linking both smoke particulate exposure and prenatal stress to poor childhood respiratory health outcomes. More research is needed in large pregnancy cohorts exposed to bushfire events to explore this further, and to design appropriate mitigation interventions, in this area of global public health importance.

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Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health

Cosín-Tomás

Cilleros-Portet

Aguilar-Lacasaña

et al. 2022

Curr Envir Health Rpt

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Purpose of Review Maternal tobacco smoking during pregnancy is of public health concern, and understanding the biological mechanisms can help to promote smoking cessation campaigns. This non-systematic review focuses on the effects of maternal smoking during pregnancy on offspring’s epigenome, consistent in chemical modifications of the genome that regulate gene expression. Recent Findings Recent meta-analyses of epigenome-wide association studies have shown that maternal smoking during pregnancy is consistently associated with offspring’s DNA methylation changes, both in the placenta and blood. These studies indicate that effects on blood DNA methylation can persist for years, and that the longer the duration of the exposure and the higher the dose, the larger the effects. Hence, DNA methylation scores have been developed to estimate past exposure to maternal smoking during pregnancy as biomarkers. Summary There is robust evidence for DNA methylation alterations associated with maternal smoking during pregnancy; however, the role of sex, ethnicity, and genetic background needs further exploration. Moreover, there are no conclusive studies about exposure to low doses or during the preconception period. Similarly, studies on tissues other than the placenta and blood are scarce, and cell-type specificity within tissues needs further investigation. In addition, biological interpretation of DNA methylation findings requires multi-omics data, poorly available in epidemiological settings. Finally, although several mediation analyses link DNA methylation changes with health outcomes, they do not allow causal inference. For this, a combination of data from multiple study designs will be essential in the future to better address this topic.

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Timing- and Dose-Specific Associations of Prenatal Smoke Exposure With Newborn DNA Methylation

Cited by 7 publications

References 21 publications

Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review

Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review

Exposure to Stress and Air Pollution from Bushfires during Pregnancy: Could Epigenetic Changes Explain Effects on the Offspring?

Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health

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