Timing of Birth and Risk of Multiple Sclerosis in the Scottish Population

Bayes, Hannah; Weir, Christopher J.; O’Leary, Colin

doi:10.1159/000268163

Cited by 55 publications

(47 citation statements)

References 39 publications

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“…The results from this study show that children born from pregnancies at higher latitudes in South America do not show higher incidence of MS later in life, as is the case with the seasonal pattern observed in the Northern hemisphere [1][2][3][4][5][6][7][8][9] . Therefore, it cannot be affirmed that there is a clear relationship between lower sun exposure in winter pregnancies and the development of MS later in the offspring's life in South America.…”

Section: Discussionmentioning

confidence: 72%

Multiple sclerosis in South America: month of birth in different latitudes does not seem to interfere with the prevalence or progression of the disease

Fragoso

Adoni

Almeida

et al. 2013

Arq. Neuro-Psiquiatr.

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Objective To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results Analysis of data from 1207 MS patients and 1207 control subjects did not show any significant variation in the month of birth regarding the prevalence of MS in four latitude bands (0–10; 11–20; 21–30; and 31–40 degrees). There was no relationship between the month of birth and the severity of disease in each latitude band. Conclusion The results from this study show that MS patients born to mothers who were pregnant at different Southern latitudes do not follow the seasonal pattern observed at high Northern latitudes.

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Section: Discussionmentioning

confidence: 72%

Multiple sclerosis in South America: month of birth in different latitudes does not seem to interfere with the prevalence or progression of the disease

Fragoso

Adoni

Almeida

et al. 2013

Arq. Neuro-Psiquiatr.

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“…1 The level of solar radiation and UV radiation has been implicated as the cause of this difference in prevalence. 2,3 There is also a month-of-birth effect in MS susceptibility, with fewer cases born during autumn months and more cases born in spring compared with healthy controls, 4,5 which could be linked to differences in climate during the year, including sun exposure.…”

Section: Introductionmentioning

confidence: 99%

Confirmation of association between multiple sclerosis and CYP27B1

et al. 2010

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Multiple sclerosis, MS (OMIM No. 126200), is a complex inflammatory disease that is characterized by lesions in the central nervous system. Both genes and other environmental factors influence disease susceptibility. One of the environmental factors that has been implicated in MS and autoimmune disease, such as type 1 diabetes, is vitamin D deficiency, in which patients have lower levels of 25-hydroxyvitamin D3 (25-OHD 3 ) in blood than do controls. Previtamin D 3 is produced in the skin, and turned into 25-OHD 3 in the liver. In the kidney, skin and immune cells, 25-OHD 3 is turned into bioactive 1,25(OH) 2 D 3 by the enzyme coded by CYP27B1 (cytochrome P450 family 27 subfamily B peptide 1) on chromosome 12q13.1-3. 1,25(OH) 2 D 3 binds to the vitamin D receptor, expressed in T cells and antigen-presenting cells. 1,25(OH) 2 D 3 has a suppressive role in the adaptive immune system, decreasing T-cell and dendritic cell maturation, proliferation and differentiation, shifting the balance between T-helper 1 (Th1) and Th2 cells in favor of Th2 cells and increasing the suppressive function of regulatory T cells. Rs703842 in the 12q13-14 region was associated with MS in a recent study by the Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene). We show associations with three SNPs in this region in our Swedish materials (2158 cases, 1759 controls) rs4646536, rs10877012 and rs10877015 (P¼0.01, 0.01 and 3.5Â10 À3 , respectively). We imputed rs703842 SNP and performed a joint analysis with the ANZgene results, reaching a significant association for rs703842 (P¼5.1Â10 À11 ; odds ratio 0.83; 95% confidence interval 0.79-0.88). Owing to its close association with 25-OHD 3 , our results lend further support to the role of vitamin D in MS pathology.

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“…The study was based on a linkage between the Danish Multiple Sclerosis Registry, 18 the Danish Civil Registration System, 19 and DBSS from the DNSB. 20 Residual DBSS have been systematically stored at 220 8 C for individuals born in Denmark since May 1, 1981. The biobank is considered close to complete for virtually all newborns in Denmark since 1982, corresponding to approximately 1.8 million samples.…”

mentioning

confidence: 99%

Neonatal vitamin D status and risk of multiple sclerosis

et al. 2017

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Objective: As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS. Methods:We carried out a matched case-control study. Dried blood spots samples (DBSS) belonging to 521 patients with MS were identified in the Danish Newborn Screening Biobank.

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Timing of Birth and Risk of Multiple Sclerosis in the Scottish Population

Cited by 55 publications

References 39 publications

Multiple sclerosis in South America: month of birth in different latitudes does not seem to interfere with the prevalence or progression of the disease

Multiple sclerosis in South America: month of birth in different latitudes does not seem to interfere with the prevalence or progression of the disease

Confirmation of association between multiple sclerosis and CYP27B1

Neonatal vitamin D status and risk of multiple sclerosis

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