Timing of Morphine Administration Differentially Alters Paraventricular Thalamic Neuron Activity

McDevitt, Dillon S.; Graziane, Nicholas

doi:10.1523/eneuro.0377-19.2019

Cited by 17 publications

(13 citation statements)

References 98 publications

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“…The PVT has recently emerged as an important regulator of aversive motivated states and of opioid withdrawal symptoms (Zhu et al 2016). During early withdrawal from repeated morphine injections, increased synaptic strength (increased A/N ratio) is observed onto PVT neurons as well as an increase in neuronal activity (McDevitt and Graziane 2019). Early morphine withdrawal also increases synaptic strength in the PVT-NAshell projection (increased A/N ratio and increased surface expression of GluA2-lacking AMPAR).…”

Section: Paraventricular Nucleus Of the Thalamus Pathwaysmentioning

confidence: 99%

Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction

Heinsbroek

Vries

Peters

2020

Cold Spring Harb Perspect Med

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Glutamate is the main excitatory neurotransmitter in the brain and is of critical importance for the synaptic and circuit mechanisms that underlie opioid addiction. Opioid memories formed over the course of repeated drug use and withdrawal can become powerful stimuli that trigger craving and relapse, and glutamatergic neurotransmission is essential for the formation and maintenance of these memories. In this review, we discuss the mechanisms by which glutamate, dopamine, and opioid signaling interact to mediate the primary rewarding effects of opioids, and cover the glutamatergic systems and circuits that mediate the expression, extinction, and reinstatement of opioid seeking over the course of opioid addiction.

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Section: Paraventricular Nucleus Of the Thalamus Pathwaysmentioning

confidence: 99%

Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction

Heinsbroek

Vries

Peters

2020

Cold Spring Harb Perspect Med

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“…Moreover, PVT neurons encode multiple salient features of sensory stimuli, including aversive valence ( Li et al, 2011 ; Yasoshima et al, 2007 ; Zhu et al, 2018 ). In addition, PVT neurons increase their firing rate and exhibit an increased AMPA/NMDA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid/N-methyl- d -aspartate) current ratio 24 h after non-contingent morphine exposure in mice ( McDevitt and Graziane, 2019 ), indicating that the PVT is recruited during early opioid withdrawal to drive aversive states ( Zhu et al, 2016 ). This is consistent with our data, showing that activation of the PVT→NAc pathway during early (24 h) withdrawal from heroin self-administration drives aversion (e.g., rtCPA) and potentiates heroin seeking.…”

Section: Discussionmentioning

confidence: 99%

Extinction blunts paraventricular thalamic contributions to heroin relapse

et al. 2021

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SUMMARY Here, we use optogenetics and chemogenetics to investigate the contribution of the paraventricular thalamus (PVT) to nucleus accumbens (NAc) pathway in aversion and heroin relapse in two different heroin self-administration models in rats. In one model, rats undergo forced abstinence in the home cage prior to relapse testing, and in the other, they undergo extinction training, a procedure that is likened to cognitive behavioral therapy. We find that the PVT→NAc pathway is both sufficient and necessary to drive aversion and heroin seeking after abstinence, but not extinction. The ability of extinction to reduce this pathway’s contribution to heroin relapse is accompanied by a loss of synaptic plasticity in PVT inputs onto a specific subset of NAc neurons. Thus, extinction may exert therapeutic reductions in opioid seeking by altering synaptic plasticity within the PVT→NAc pathway, resulting in reduced aversion during opioid withdrawal as well as reduced relapse propensity.

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“…Mice were singly housed for the following reasons. First, we have reliably developed morphine conditioned place preference (CPP) in singly-housed mice (Graziane et al, 2016;McDevitt and Graziane, 2019). Second, evidence suggests that socially isolated rodents are more vulnerable to developing drug-context associations (Whitaker et al, 2013).…”

Section: Animalsmentioning

confidence: 99%

“…Therefore, CPP provides a valuable tool used to understand how drugs of abuse become associated with environmental contexts, which is implicated in context-induced drug craving and relapse (O'Brien and Ternes, 1986;O'Brien et al, 1992). We have found that 5 days of morphine (10 mg/kg) conditioning elicits robust morphine CPP (Graziane et al, 2016;McDevitt and Graziane, 2019). However, it is unclear whether this ''drug contextseeking'' behavior is mediated by negative affective states.…”

Section: Introductionmentioning

confidence: 99%