Timing of suicide attempts by self‐poisoning during pregnancy and pregnancy outcomes

Czeizel, Andr̀ew E.; Timár, L; Susánszky, Éva

doi:10.1016/s0020-7292(99)00007-7

Cited by 26 publications

(21 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of studies that have assessed the impact of suicidal ideation during pregnancy on fetal development have done so in the context of self-poisoning. A series of 15 articles were published from the Budapest Monitoring System of Self-Poisoning Pregnant Women that evaluated the potential effects of large doses of drugs on fetal development among pregnant women who attempted suicide (Czeizel et al, 1997, Czeizel et al, 1999, Timmermann et al, 2009, Gidai et al, 2008c, Gidai et al, 2008a, Gidai et al, 2008d, Gidai et al, 2008b, Gidai et al, 2010, Petik et al, 2008a, Petik et al, 2008b, Petik et al, 2012, Timmermann et al, 2008b, Timmermann et al, 2008a, Timmermann et al, 2008c). With regards to congenital anomalies, the primary outcomes of these studies, no statistically significant associations were reported with self-poisoning (Czeizel et al, 1997, Czeizel et al, 1999, Timmermann et al, 2009, Gidai et al, 2008c, Gidai et al, 2008a, Gidai et al, 2008d, Gidai et al, 2008b, Gidai et al, 2010, Petik et al, 2008a, Petik et al, 2008b, Petik et al, 2012, Timmermann et al, 2008b, Timmermann et al, 2008a, Timmermann et al, 2008c).…”

Section: Resultsmentioning

confidence: 99%

“…The majority of drugs used for self-poisoning in these studies were also not associated with mental retardation, low birth weight, or preterm birth. However, investigators found that large doses of Tardyl (combination of amobarbital, glutethimide, and promethazine) were associated with an increased prevalence of mental retardation among exposed infants compared to their unexposed siblings (29.6% vs. 0%, p<0.0001) (Petik et al, 2012) and that self-poisoning during pregnancy was associated with increased odds of very early fetal loss (OR=6.09, 95% CI: 3.82–9.71) and decreased odds of live birth (OR=0.08, 95% CI: 0.23–0.72) (Czeizel et al, 1999). …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Suicidal ideation in pregnancy: an epidemiologic review

Gelaye

Kajeepeta

Williams

2016

Arch Womens Ment Health

138

125

View full text Add to dashboard Cite

Objective Suicidal behaviors are the leading causes of injury and death worldwide, and are leading causes of maternal deaths in some countries. One of the strongest risk factors, suicidal ideation, is considered a harbinger and distal predictor of later suicide attempt and completion, and also presents an opportunity for interventions prior to physical self-harm. The purpose of this systematic epidemiologic review is to synthesize available research on antepartum suicidal ideation. Data sources Original publications were identified through searches of the electronic databases using the search terms pregnancy, pregnant women, suicidal ideation, and pregnan* and suicid* as root searches. We also reviewed references of published articles. Study Selection We identified a total of 2,626 articles through the electronic database search. After irrelevant and redundant articles were excluded 57 articles were selected. The selected articles were original articles that focused on pregnancy and suicidal ideation. Results Of the 57 included articles, 20 reported prevalence, 26 reported risk factors, 21 reported consequences of antepartum suicidal ideation, and 5 reported on screening measures. Available evidence indicates that pregnant women are more likely than the general population to endorse suicidal ideation. Additionally, a number of risk factors for antepartum suicidal ideation were identified including intimate partner violence, <12 years education, and major depressive disorder. Conclusion There is a need for enhanced screening for antepartum suicidal ideation. The few screening instruments that exist are limited as they were primarily developed to measure antepartum and postpartum depression. Given a substantial proportion of women with suicidal ideation do not meet clinical thresholds of depression and given the stress–diathesis model that shows susceptibility to suicidal behavior independent of depressive disorders, innovative approaches to improve screening and detection of antepartum suicidal ideation are urgently needed.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Suicidal ideation in pregnancy: an epidemiologic review

Gelaye

Kajeepeta

Williams

2016

Arch Womens Ment Health

138

125

View full text Add to dashboard Cite

show abstract

“…Women who die from homicide during pregnancy are often not included in maternal mortality statistics. Based on reviews of 651 autopsy charts of women aged 15 to 50 who died during an 8-year period of time in Washington, DC, Krulewitch 34 Sao Paulo, Brazil 1988 -1997 Accidents and homicides combined 3 Czeizel AE, et al 35 Budapest, Hungary 1985-1993 Suicide attempts and low numbers 2 suicides Rizzi RG, et al 36 Argentina 1992-1996 Low numbers 1 homicide, 2 suicides Harper MA, et al 37 North Carolina, USA 1992-1994 Duplicate dataset 22 homicides, 5 suicides Gissler M, et al 38 Finland 1987-1994 Duplicate dataset Frautschi S, et al 39 Worldwide 1960 -1994 Review article 0 Harris C, et al 40 Gales, England 1990…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-one articles, which contained numbers of suicides during and after pregnancy, are included in Table 2 (6,7,9,10,2,16,(18)(19)(20)(21)(22)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). The 16 articles that met exclusion criteria are compiled in Table 3 (23,(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Studies were excluded if they contained duplicate datasets, case reports of less than 3 events, or suicide attempts only.…”

Section: Sourcesmentioning

confidence: 99%

Pregnancy-Associated Death: A Qualitative Systematic Review of Homicide and Suicide

Shadigian¹,

Bauer²

2005

Obstetrical & Gynecological Survey

115

View full text Add to dashboard Cite

A systematic review of the literature on maternal homicide and suicide was performed to understand the causes of pregnancy-associated death. Forty-four studies examined homicide and/or suicide and pregnancy-associated death (defined as the death of a woman, from any cause, while she is pregnant or within 1 year of termination of pregnancy) (1). Of these studies, 747 homicides and 349 suicides were identified. All studies were included except duplicate datasets, case reports of less than 3 events, suicide attempts, unpublished manuscripts, review articles, or non-English studies. Homicide is a leading cause of pregnancy-associated death and suicide is also an important cause of death among pregnant and recently pregnant women. Healthcare providers should understand that homicide is a leading cause of pregnancy-associated death, most commonly as a result of partner violence. Therefore, screening for both partner violence and suicidal ideation are essential components of comprehensive medical care for women during and after pregnancy.

show abstract

“…The majority of such episodes are impulsive and frequently precipitated by violent interpersonal disputes [12]. The peak time reported for self-harm attempts in pregnancy is the first trimester, after which, it declines with advanced gestational age [8,9,11,[13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Acute Poisoning During Pregnancy: Observations from the Toxicology Investigators Consortium

et al. 2015

View full text Add to dashboard Cite

Acute poisonings during pregnancy pose a particular challenge to health care providers because of the potential for an immediate life threat or possible life-long implications for both the mother and fetus, including teratogenicity of the poison or its antidote. We describe recent consequential exposures among pregnant women in the USA. We identified all poisoning cases involving pregnant women that were catalogued by the medical toxicology services across the 37 sites of the Toxicology Investigators Consortium (ToxIC) Registry of the American College of Medical Toxicology between January 2010 and December 2012. Of 17,529 exposure cases reported in the ToxIC Registry, 103 (0.6 %) involved pregnant women, 80 % of whom were symptomatic and about a quarter displayed a specific toxidrome. The majority of cases (n = 53; 51.5 %) involved intentional exposures, most commonly to pharmaceutical agents, followed by unintentional pharmaceutical exposures (10 %) and withdrawal syndromes (9 %). Non-opioid analgesics were the most common class of agents encountered (31 %), followed by sedative-hypnotics/muscle relaxants (18 %), opioids (17 %), anti-convulsants (10 %), and anti-depressants (10 %). Over a third of cases involved exposure to multiple substances, and 32 % involved exposure to more than one drug class. The most commonly administered antidotes were N-acetylcysteine (23 %), sodium bicarbonate (10 %), flumazenil (4 %), and physostigmine (4 %). About half of acute poisoning cases among pregnant women presenting for emergency care involved intentional exposures, mostly with over-the-counter analgesics and psychoactive medications. Clinicians should be cognizant of the unique circumstances, maternal and fetal risks, and management principles of the acutely poisoned pregnant woman.

show abstract

Timing of suicide attempts by self‐poisoning during pregnancy and pregnancy outcomes

Abstract: Most suicide attempts by self-poisoning occurred after the early recognition of unwanted pregnancies and most resulted in a very early fetal loss. Pregnancies with advanced gestation months had a significantly lower proportion of attempting suicide.

Cited by 26 publications

References 17 publications

Suicidal ideation in pregnancy: an epidemiologic review

Suicidal ideation in pregnancy: an epidemiologic review

Pregnancy-Associated Death: A Qualitative Systematic Review of Homicide and Suicide

Acute Poisoning During Pregnancy: Observations from the Toxicology Investigators Consortium

Contact Info

Product

Resources

About