TIMP3 involvement and potentiality in the diagnosis, prognosis and treatment of diabetic nephropathy

Casagrande, Viviana; Federici, Massimo; Menghini, Rossella

doi:10.1007/s00592-021-01766-y

Cited by 11 publications

(9 citation statements)

References 66 publications

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“…Diabetic nephropathy is a key factor in the development of CKD ( Molitch et al, 2003 ), with its defining features being an increase in albuminuria, decline in the glomerular filtration rate (GFR), and loss of podocytes. In a retrospective study, the potential roles of TIMP3 and its related noncoding RNA in the progression of diabetic nephropathy were investigated ( Casagrande et al, 2021 ). An example of the moderation of podocellular damage in diabetic nephrotic disease is the overexpression of non-coding RNA (lincRNA) 4930556M19Rik which downregulates miR-27a-3p and upregulates TIMP3 ( Fan and Zhang, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring the genetic causal association of TIMP3 on CKD and kidney function: a two-sample mendelian randomization

Chen,

Chen

et al. 2024

Front. Genet.

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Background: Numerous studies have demonstrated a positive association between the level of tissue inhibitor of metalloproteinase 3 (TIMP3) and chronic kidney disease (CKD). Nevertheless, whether those associations reflect causal links still to be determined. This study intended to research the causal relationship of TIMP3 with CKD and markers of kidney function, such as creatinine‐based estimated glomerular filtration rate (eGFRcrea), cystatin C‐based estimated glomerular filtration rate (eGFRcys), eGFRcrea in diabetics (eGFRcrea (DM)) and eGFRcrea in non diabetics (eGFRcrea (No DM)).Methods: In this study, we investigated the causal relationships between TIMP3 and CKD and kidney function markers using a two-sample Mendelian randomization (MR) technique. We used summary level datasets for TIMP3 and CKD from genome-wide association studies that we were able to access through the study by Suhre K and Pattaro C.Results: We found that TIMP3 had a significant positive causal effect on the risk of CKD (Inverse variance weighted (IVW):odds ratio (OR):0.962, 95% confidence interval (CI): (0.936-0.988),P:0.005). However TIMP3 levels had no significant effect on risk of eGFRcys (PIVW: 0.114),eGFRcrea (PIVW:0.333). After grouping patients based on their diabetes status, we found that genetically higher levels of TIMP3 had a significant impact on eGFRcrea in participants without diabetes (OR:1.003,95%CI (1.001-1.006),P IVW:0.007), but not in participants with diabetes (PIVW = 0.057). Heterogeneity and pleiotropy analyses were carried out to verify the accuracy of the MR findings. Their findings were all not statistically significant.Conclusion: Our study suggests that TIMP3 may be causally associated with CKD and eGFRcrea (No DM)in people of European ancestry. Strategies aimed to increase TIMP3 levels may provide new ways to delay the deterioration of renal function.

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Section: Discussionmentioning

confidence: 99%

Exploring the genetic causal association of TIMP3 on CKD and kidney function: a two-sample mendelian randomization

Chen,

Chen

et al. 2024

Front. Genet.

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“…Anti-Inflammatory Therapy . Inflammation can greatly aggravate the development of DN, so anti-inflammatory therapy is necessary [ 16 ]. Aldose reductase inhibitors act on the polyol pathway, preventing the conversion of glucose to sorbitol.…”

Section: Advances In Dnmentioning

confidence: 99%

Advance in the Correlation between Diabetic Nephropathy and Abnormal Serum Thyroid Hormone Levels in Patients

Liu

2023

Emergency Medicine International

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This study was developed to explore the correlation between diabetic nephropathy (DN) and abnormal serum thyroid hormone (TH) levels in patients, which can provide a reference for disease prevention and control in patients with DN. DN is the most serious complication of diabetes. The mortality rate of diabetic patients with DN is approximately 30 times higher than that of diabetic patients without DN. DN leads to high blood sugar, which causes vascular dysfunction in patients, causes cardiovascular disease, aggravates the disease and disease complexity, and thus increases the mortality of patients. DN patients often have oxidative stress and even fibrosis in severe cases. TH has a potential renal protective effect and can also regulate glucose metabolism and improve abnormal glucose tolerance and insulin resistance. Abnormal serum TH levels increase the risk of DN. Normal thyroid function plays an important role in regulating the physiological functions of the human body. Hormonal disorders promote the development of diabetes mellitus (DM) into DN. The pathogenesis, clinical manifestations, detection, and treatment methods of DN were reviewed in this study. The research progress of the influence of TH on DN was analyzed. This study is conducive to clinical research on DN and provides a reference.

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“…Early diabetic nephropathy is mostly manifested by increased excretion rate of microalbumin in the urine, and decreased glomerular filtration rate can be seen in renal function examination with the aggravation of the disease. 2 Those with severe disease may involve dialysis and kidney transplantation, and will have a significantly increased probability of cardiovascular disease along with the decline of renal function, which will seriously endanger life safety. 3 Studies have revealed that there is a correlation between nephropathy and abnormal changes in bone metabolism indicators in the body.…”

Section: Introductionmentioning

confidence: 99%

Changes of Serum Bone Metabolism Indexes and Ultrasonic Bone Mineral Density in Patients with Diabetic Nephropathy at Different Stages and their effects on Diabetic Renal Microvascular Complications

Han

Wang²,

Ma³

et al. 2023

Pak J Med Sci

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Objective: To determine the changes in serum bone metabolism indexes and ultrasonic bone mineral density (BMD) in patients with diabetic nephropathy at different stages, and their effects on diabetic renal microvascular complications. Methods: This is a clinical comparative study. One hundred twenty two diabetic patients admitted to the Baoding No.1 Central Hospital from January 2020 to March 2022 were selected as subjects and divided into three groups according to their actual condition: the simple diabetes (Group-A, 40 cases), diabetic nephropathy with micro urinary protein (Group-B, 40 cases) and diabetic nephropathy with massive proteinuria (Group-C, 42 cases). Another 36 healthy subjects were selected as the control group. Differences in serum bone metabolism indexes and ultrasound BMD levels were compared. Results: Twenty five hydroxy-vitamin D, BGP, T-PINP and ultrasound BMD levels in the control group were > Group-A > Group-B > Group-C, PTH and β-CTX in the control group were < Group-A < Group-B < Group-C, statistically significant differences (p<0.05). The urinary albumin to urinary creatinine ratio (ACR) value in Group-B was significantly lower than Group-C (p<0.05). Logistic regression analysis showed that 25-hydroxy-vitamin D, PTH, BGP, β-CTX, T-PINP and ultrasound BMD were the influencing factors of diabetic renal microvascular complications (p<0.05). Conclusion: Bone metabolism indexes and ultrasound bone mineral density are abnormally expressed in patients with diabetic nephropathy at different stages, which are closely related to the urine protein of patients. They have important clinical value in the diagnosis of early diabetic nephropathy. doi: https://doi.org/10.12669/pjms.39.3.6650 How to cite this: Han L, Wang S, Ma J, Song N, Wang Z, Yao M. Changes of Serum Bone Metabolism Indexes and Ultrasonic Bone Mineral Density in Patients with Diabetic Nephropathy at Different Stages and their effects on Diabetic Renal Microvascular Complications. Pak J Med Sci. 2023;39(3):656-661. doi: https://doi.org/10.12669/pjms.39.3.6650 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TIMP3 involvement and potentiality in the diagnosis, prognosis and treatment of diabetic nephropathy

Cited by 11 publications

References 66 publications

Exploring the genetic causal association of TIMP3 on CKD and kidney function: a two-sample mendelian randomization

Exploring the genetic causal association of TIMP3 on CKD and kidney function: a two-sample mendelian randomization

Advance in the Correlation between Diabetic Nephropathy and Abnormal Serum Thyroid Hormone Levels in Patients

Changes of Serum Bone Metabolism Indexes and Ultrasonic Bone Mineral Density in Patients with Diabetic Nephropathy at Different Stages and their effects on Diabetic Renal Microvascular Complications

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