Tinnitus Abnormal Brain Region Detection Based on Dynamic Causal Modeling and Exponential Ranking

Tsai, Ming-Chuan; Cai, Yixi; Wang, Chang‐Dong; Zheng, Yiqing; Ou, Jialing; Chen, Yanhong

doi:10.1155/2018/8656975

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…Previous studies have reported reduced signal transmission to the auditory cortex using electroencephalography data analysis [41]. However, studies have also reported that the primary auditory cortex and somatomotor networks are characterized by increased connectivity in patients with tinnitus [42], indicating possibly heavier information flow of the brain regions. Thus, the communication from auditory and somatomotor networks to other brain regions may be enhanced.…”

Section: Discussionmentioning

confidence: 99%

Brain Effective Connectivity Analysis Facilitates the Treatment Outcome Expectation of Sound Therapy in Patients With Tinnitus

Liu

Chen

et al. 2023

IEEE Trans. Neural Syst. Rehabil. Eng.

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Tinnitus is associated with abnormal functional connectivity of multiple regions of the brain. However, previous analytic methods have disregarded information on the direction of functional connectivity, leading to only a moderate efficacy of pretreatment planning. We hypothesized that the pattern of directional functional connectivity can provide key information on treatment outcomes. Sixty-four participants were enrolled in this study: eighteen patients with tinnitus were categorized into the effective group, twenty-two patients into the ineffective group, and twenty-four healthy participants into the healthy control group. We acquired resting-state functional magnetic resonance images prior to sound therapy and constructed an effective connectivity network of the three groups using an artificial bee colony algorithm and transfer entropy. The key feature of patients with tinnitus was the significantly increased signal output of the sensory network, including the auditory, visual, and somatosensory networks, and parts of the motor network. This provided critical insights into the gain theory of tinnitus development. The altered pattern of functional information orchestration, represented by a higher degree of hypervigilance-driven attention and enhanced multisensory integration, may explain poor clinical outcomes. The activated gating function of the thalamus is one of the key factors for a good prognosis in tinnitus Manuscript

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Section: Discussionmentioning

confidence: 99%

Brain Effective Connectivity Analysis Facilitates the Treatment Outcome Expectation of Sound Therapy in Patients With Tinnitus

Liu

Chen

et al. 2023

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…Different management strategies have been recommended for tinnitus, including psychological counseling, cognition therapy, and sound therapy; however, there is no definitive cure for all types of tinnitus (Chen et al, 2017;Tsai et al, 2018). Additionally, the neurological mechanisms of tinnitus remain unclear, and the underlying causes have not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss

Zhou

Chen

et al. 2021

Brain Imaging and Behavior

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The present study combined resting-state functional connectivity (FC) and Granger causality analysis (GCA) to explore frontostriatal network dysfunction in unilateral acute tinnitus (AT) patients with hearing loss. Methods:The participants included 42 AT patients and 43 healthy control (HC) subjects who underwent resting-state functional magnetic resonance imaging (fMRI) scans. Based on the seed regions in the frontostriatal network, FC and GCA were conducted between the AT patients and HC subjects. Correlation analyses were used to examine correlations among altered FC values, GCA values, and clinical features in AT patients.Results: Compared with HCs, AT patients showed a general reduction in FC between the seed regions in the frontostriatal network and nonauditory areas, including the frontal cortices, midcingulate cortex (MCC), supramarginal gyrus (SMG), and postcentral gyrus (PoCG). Using the GCA algorithm, we detected abnormal effective connectivity (EC) in the inferior occipital gyrus (IOG), MCC, Cerebelum_Crus1, and PoCG. Furthermore, correlations between disrupted FC/EC and clinical characteristics, especially tinnitus distress-related characteristics, were found in AT patients. Conclusions:Our work demonstrated abnormal FC and EC between the frontostriatal network and several nonauditory regions in AT patients with hearing loss, suggesting that multiple large-scale network dysfunctions and interactions are involved in the perception of tinnitus. These findings not only enhance the current understanding of the frontostriatal network in tinnitus but also serve as a reminder of the importance of focusing on tinnitus at an early stage.

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“…Of these, about 10-20% of patients are affected severely and sought medical therapy (Cai et al, 2017;Yang et al, 2018). At present, the clinical treatment for tinnitus includes counseling, sound therapy, cognitive behavioral therapy, etc., however, no identified treatments have been effective and unequivocal to all types of tinnitus (Chen et al, 2017b;Tsai et al, 2018). One of the most important reasons is that the mechanism of tinnitus remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss

Cai

Xie

et al. 2020

Front. Neurosci.

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The neural bases in acute tinnitus remains largely undetected. The objective of this study was to identify the alteration of the brain network involved in patients with acute tinnitus and hearing loss. Methods: Acute tinnitus patients (n = 24) with hearing loss and age-, sex-, education-matched healthy controls (n = 21) participated in the current study and underwent resting-state functional magnetic resonance imaging (fMRI) scanning. Regional homogeneity and amplitude of low-frequency fluctuation were used to investigate the local spontaneous neural activity and functional connectivity (FC), and Granger causality analysis (GCA) was used to analyze the undirected and directed connectivity of brain regions. Results: Compared with healthy subjects, acute tinnitus patients had a general reduction in FC between auditory and non-auditory brain regions. Based on FC analysis, the superior temporal gyrus (STG) revealed reduced undirected connectivity with nonauditory brain regions including the amygdala (AMYG), nucleus accumbens (NAc), the cerebellum, and postcentral gyrus (PoCG). Using the GCA algorithm, increased effective connectivity from the right AMYG to the right STG, and reduced connectivity from the right PoCG to the left NAc was observed in acute tinnitus patients with hearing loss. The pure-tone threshold was positively correlated with FC between the AMYG and STG, and negatively correlated with FC between the left NAc and the right PoCG. In addition, a negative association between the GCA value from the right PoCG to the left NAc and the THI scores was observed. Conclusion: Acute tinnitus patients have aberrant FC strength and causal connectivity in both the auditory and non-auditory cortex, especially in the STG, AMYG, and NAc. The current findings will provide a new perspective for understanding the neuropathophysiological mechanism in acute tinnitus.

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Tinnitus Abnormal Brain Region Detection Based on Dynamic Causal Modeling and Exponential Ranking

Cited by 7 publications

References 42 publications

Brain Effective Connectivity Analysis Facilitates the Treatment Outcome Expectation of Sound Therapy in Patients With Tinnitus

Brain Effective Connectivity Analysis Facilitates the Treatment Outcome Expectation of Sound Therapy in Patients With Tinnitus

Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss

Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss

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