Tinospora cordifolia (Willd.) Miers: phytochemical composition, cytotoxicity, proximate analysis and their biological activities

Modi, Bindu; Koirala, Niranjan; Aryal, Surya P.; Shrestha, Jiban; Koirala, Shishir; Upadhyaya, J. S.; Basnyat, Ram Chandra; Nassan, Mohamed A.; Alqarni, Mohammed; Batiha, Gaber El‐Saber

doi:10.14715/cmb/2021.67.1.8

Cited by 13 publications

(5 citation statements)

References 43 publications

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“…They recorded that CCl 4 and CHCl 3 soluble fractions showed highly cytotoxic in Artemia salina with LC 50 values of 0.402 and 0.691 μg/mL [60]. Likewise, in 2021, Modi and coworkers documented that ethanol stem and leaves extract of T. c o r d i f o l i a had a cytotoxic effect in A. salina with LC 50 values of 462.38 and 676.08 μg/mL [61]. Furthermore, Jagetia and Rao studied the cytotoxic effects of DCM extract of T. cordifolia on cultured HeLa cells.…”

Section: Cytotoxic Activity Of Menispermaceaementioning

confidence: 99%

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

Tun¹,

Aminah²,

Kristanti³

et al. 2023

Cytotoxicity - Understanding Cellular Damage and Response

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Plants are the storage place for many active ingredients that are currently used in pharmaceuticals. Proofs have been expanded for ages to indicate the profitable capacity of medicinal plants used in various infections, especially for cancer treatment. The plants, Chromolaena odorata (Family Asteraceae), Croton oblongifolius Roxb. (Family Euphorbiaceae), Tinospora cordifolia (Family Menispermaceae), Melastoma malabathricum L. (Family Melastomaceae), and Dioscorea bulbifera (Family Dioscoreaceae) have been used for a long time in Myanmar’s traditional medicine. This study aimed to review systematically the cytotoxic activity of the whole plants and their extracts, fractions, and isolated compounds from these selected medicinal plants. This chapter also be substantiated for additional analysis on phytochemical constituents and pharmacological action of therapeutic plants species in Myanmar.

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Section: Cytotoxic Activity Of Menispermaceaementioning

confidence: 99%

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

Tun¹,

Aminah²,

Kristanti³

et al. 2023

Cytotoxicity - Understanding Cellular Damage and Response

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“…In one study, the alkaloid berberine was found to inhibit the enzyme phospholipase A2, which is responsible for the release of venom from the fangs of snakes. The flavonoids present in the plant have been shown to have antioxidant, anti-inflammatory, and anti-venom properties 100 . Several flavonoids, such as quercetin and kaempferol, have been found to inhibit the enzyme hyaluronidase, which is responsible for the spread of venom in the body.…”

Section: Phytochemical Constituents and Its Medicinal Propertiesmentioning

confidence: 99%

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

T. Dhanya,

Kavinila,

David Paul Raj

2024

JNR

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Snakebite is a significant public health concern in many parts of the world, particularly in regions where venomous snakes are prevalent. Snakebites can range from mild to life-threatening, depending on the species of snake, the amount of venom injected, and the location of the bite. Globally, an estimated 5 million people are affected by snake bites each year, according to recent statistics. Since ancient times, traditional medicinal plants have been used to cure a wide range of illnesses, including snake bites. Secondary metabolites contained in plants were efficient in reducing the effects of snake venom. Snake venom is a potent toxin that can cause severe damage to the human body, affecting the nervous system, cardiovascular system, or both. Symptoms can range from mild swelling to life-threatening paralysis, respiratory failure, and hemorrhage. Enzyme activity is inhibited by flavonoids, alkaloids, and tannins, which additionally hinder blood from clotting and lessen inflammation. Treatments for snake bites that are more beneficial and less hazardous could result from the isolation and synthesis of natural drugs. With the use of cutting-edge scientific methods, we can maximize their potential and use their secondary metabolites to develop novel medications and therapies. The study of these plants and their potential uses in contemporary medicine requires more funding and investigation. This will advance our knowledge of these plants and help us create cures for some of the most lethal diseases.

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“…The methanol extract from the leaves and stem of Tinospora cordifolia from Ilam District of Nepal, exhibited elevated Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) as compared to the hexane extract. This suggests a greater efficiency in extracting polar compounds by using a polar solvent (Modi, Koirala, et al, 2021). The secondary metabolites present in the plant can vary even within the same plant due to differences in sampling methods, analysis of plant parts, solvents used for extraction, harvest time, storage, growing climate conditions, genetic factors, and many more (Aryal et al, 2021).…”

Section: Figure 1 Gallic Acid Standard Curve (765 Nm)mentioning

confidence: 99%

Evaluation of Antioxidant Capacity of Methanol Extracts of Leaf and Stem Bark of Tinospora Cordifolia

Khanal

2023

Prithvi J. Res. Innov.

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Conventionally used herbs are the major sources of biologically active phytoconstituents that are extensively used for the management of several health complications particularly in developing countries. Tinospora cordifolia, locally known as Gurjo, is one of the most widely utilized medicinal plants in Nepal. This study was carried out on quantifying the total phenolic and flavonoid contents, and evaluating antioxidant potential of the methanolic extracts of stem barks and leaf of a wild plant collected from Rupa Village of Kaski District of Nepal. The Folin-Ciocalteu reagent (FCR) method showed a total phenolic content of 50.84 ± 0.38 and 41.39 ± 0.44 mg GAE/g in the extracts of stem barks and leaves respectively. The AlCl3-based colorimetric method showed the total flavonoid contents of 27.44 ± 0.68 mg QE/g in stem barks and 18.44 ± 0.25 mg QE/g in the leaves extract. Besides, the antioxidant activity was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. The stem bark exhibited higher antioxidant activity (IC50 = 36.50 ± 0.79 µg/mL) than that of the leaf extract (IC50 = 50.77 ± 1.29 µg/mL), as compared to the standard ascorbic acid (IC50 = 10.82 ± 0.04 µg/mL). These findings validate the traditional practice of using the plant, underscore the existence of a diverse range of bioactive compounds, and highlight the necessity for further investigations into its potential health benefits.

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Tinospora cordifolia (Willd.) Miers: phytochemical composition, cytotoxicity, proximate analysis and their biological activities

Cited by 13 publications

References 43 publications

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

Evaluation of Antioxidant Capacity of Methanol Extracts of Leaf and Stem Bark of Tinospora Cordifolia

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