TiO2 nanoparticles and ionic liquid platform for selective electrochemical determination of indacaterol in pharmaceutical formulations and human fluids: application to content uniformity

Atty, Shimaa A.; Farouk, Maha; Hussein, Lobna A.; Magdy, Nancy; Yamani, Hend Z.

doi:10.1007/s13738-019-01778-0

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…The electroactive area of the modified electrode was determined by recording cyclic voltammogram against variable scan rates of 0.1 mM K 3 Fe(CN) 6 in 0.1 M KCl solution. The electroactive area was calculated according to Randles-Sevcik equation 32 Where Ip is the peak current, n is the number of electron transferred in the electrochemical process, A is electrode surface area, D is the diffusion coefficient, C is the redox concentration, v is the scan rate, for K 3 Fe(CN) 6 , the value of D equals 7.6 × 10 −6 cm 2 s −1 and n = 1.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Ultra-Sensitive Modified Electrode for Eco-Friendly Determination of Neurotoxic Heavy Metals in Beef, Dairy Products and Biological Samples

Atty¹,

Shallan²,

Abdel-Hakim³

et al. 2022

J. Electrochem. Soc.

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Trace levels of cadmium, lead, and mercury heavy metals are toxic to the human nervous system. These metals occur naturally and as a result of inappropriate agricultural and industrial practices. In response to this problem, a novel modified electrode was constructed for the simultaneous determination of cadmium, lead, and mercury. The modified electrode was prepared by incorporating zirconium oxide nanoparticles (ZrO2 NPs) and multi-walled carbon nanotubes into a carbon paste electrode. Transmission electron microscopy and electrochemical impedance spectroscopy were employed for the characterization of the modified electrode. Different variables that affect the electrochemical response were studied and optimized. The proposed electrode exhibits a wide linear range and lower detection limits obtained were 2.77 x 10-10, 2.46 x 10-10 and 4.15 x 10-10 mol L−1 for cadmium, lead, and mercury, respectively. The method was successfully applied for the determination of these neurotoxic heavy metals in beef, milk, urine, plasma, and omega-3 capsules.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Ultra-Sensitive Modified Electrode for Eco-Friendly Determination of Neurotoxic Heavy Metals in Beef, Dairy Products and Biological Samples

Atty¹,

Shallan²,

Abdel-Hakim³

et al. 2022

J. Electrochem. Soc.

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“…In this system, the slope were 0.0571 and 0.0501, αn was calculated to be 1.036 and 1.18 for PHZ and TMP at CNT/PS/MCPE respectively. Since for a totally irreversible electron transfer, α assumed as 0.5 40,41 then n was calculated to be 2.07 and 2.36 for PHZ and TMP, respectively at modified electrode which indicate that two electrons is involved in the oxidation of PHZ and TMP.…”

Section: = (mentioning

confidence: 99%

Analytical Eco-Scale for Evaluating the Greenness of Advanced Voltammetric Method Used for the Simultaneous Analysis of Combined Urinary Tract Infection Drugs in Different Matrices

Hussein¹,

elzanfaly²,

Abdelkawy³

et al. 2022

J. Electrochem. Soc.

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Phenazopyridine hydrochloride (PHZ) and Trimethoprim (TMP) are formulated together to treat urinary tract infections. The current work describes the first electrochemical sensor to simultaneously determine PHZ and TMP with good anodic peak potential separation. A rapid, simple and sensitive electrochemical oxidation based on using multiwalled carbon nanotubes (CNT) and sugar polymer (PS) as modifier carbon paste (CNT/PS/MCPE) is described. Under optimized conditions and by using square wave voltammetry, a wide linearity range of 2×10-7 M to 1 ×10-4 M was obtained for both drugs with good recovery in pH 7. The high sensitivity and good reproducibility enabled using the modified electrode to determine PHZ and TMP in pharmaceutical formulation, human serum and urine. The proposed voltammetric method was statistically compared with the reported spectrophotometric method and the results obtained indicate no significant differences. Moreover, the fabricated sensor was applicable for the determination of PHZ and TMP in presence of common interfering molecules, ascorbic acid and uric acid which can be present in the plasma and urine. Analytical Eco-scale was applied to evaluate the greenness of the proposed voltammetric method.

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“…SWV has many advantages over other analytical methods in pharmaceutical research. These merits can be summarized in cost-effectiveness, low energy consumption, minor sample pre-treatment, versatility to small volume samples, and high efficiency with a wide range of applications [5][6][7][8]. Seventy to eighty percent of pregnant women experience nausea and vomiting during their pregnancy [9].…”

Section: Introductionmentioning

confidence: 99%

“…Fig 6. Voltammogram of PYR, DOX, and DOX DEG in acetate buffer (pH 7.0) at scan rate 20.0 mV s. −1 using ZrO 2 5%/ MWCNT 0.5%/MCPE…”

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confidence: 99%

Analytical Eco-Scale for Evaluating the Uniqueness of Voltammetric Method used for Determination of Antiemetic Binary Mixture Containing Doxylamine Succinate in Presence of its Toxic Metabolite

et al. 2022

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Green analytical procedures are gaining popularity in the pharmaceutical research area as a way to reduce environmental impact and improve analyst health safety. The current work presents a green and sensitive electrochemical carbon paste electrode that has been chemically modified with zirconium dioxide and multi-walled carbon nanotubes for estimation of pyridoxine HCl (PYR) and doxylamine succinate (DOX) using the square wave voltammetric technique. Under optimum conditions, the linearity ranges were 20.00–2000.00 ng mL−1 and 2.00–20.00 µg mL−1 for both drugs in the 1st linear segment and 2nd linear segment, respectively. Stability testing assesses how the quality of a drug substance changes over time, depending on environmental and laboratory factors. DOX was found to undergo oxidative degradation when refluxed for 7 h using 30% H2O2 and the degraded product (DOX DEG) (toxic metabolite) was successfully characterized utilizing LC–MS. The developed electrode showed selectivity for the determination of binary mixture in pure form, pharmaceutical form, and in the presence of DOX DEG and common interfering molecules with good recovery. The proposed method was found to be eco-friendlier than the reported method in terms of the use of hazardous chemicals and solvents, energy consumption, and waste generation. Graphical Abstract

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TiO2 nanoparticles and ionic liquid platform for selective electrochemical determination of indacaterol in pharmaceutical formulations and human fluids: application to content uniformity

Cited by 10 publications

References 22 publications

Fabrication of Ultra-Sensitive Modified Electrode for Eco-Friendly Determination of Neurotoxic Heavy Metals in Beef, Dairy Products and Biological Samples

Fabrication of Ultra-Sensitive Modified Electrode for Eco-Friendly Determination of Neurotoxic Heavy Metals in Beef, Dairy Products and Biological Samples

Analytical Eco-Scale for Evaluating the Greenness of Advanced Voltammetric Method Used for the Simultaneous Analysis of Combined Urinary Tract Infection Drugs in Different Matrices

Analytical Eco-Scale for Evaluating the Uniqueness of Voltammetric Method used for Determination of Antiemetic Binary Mixture Containing Doxylamine Succinate in Presence of its Toxic Metabolite

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