TiO2 nanoparticles can selectively bind CXCL8 impacting on neutrophil chemotaxis

Batt, Joanna; Milward, Michael; Chapple, Iain; Grant, Melissa M.; Roberts, Helen; Addison, Odessa

doi:10.22203/ecm.v035a02

Cited by 13 publications

(12 citation statements)

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“…To approach the mechanism of body reaction to TiO 2 -NP, many studies reported inflammatory effects due to TiO 2 -NP exposure, including the presence of pro-inflammatory mediators, macrophage inflammatory proteins, and other inflammatory molecules [42]. The interaction between TiO 2 -NP and inflammatory cytokines, including CXCL8, a clinically relevant pro-inflammatory chemokine, was also investigated by Batt et al [43]. The authors found that the TiO 2 -NP could preferentially adsorb CXCL8 (and IFN-γ), which leads to the disruption of neutrophil chemotaxis and modifies local inflammatory mediator concentration and might result in hampered inflammatory response.…”

Section: Resultsmentioning

confidence: 99%

General review of titanium toxicity

et al. 2019

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Background Titanium is a commonly used inert bio-implant material within the medical and dental fields. Although the use of titanium is thought to be safe with a high success rate, in some cases, there are rare reports of problems caused by titanium. In most of these problematic reports, only individual reports are dominant and comprehensive reporting has not been performed. This comprehensive article has been prepared to review the toxicity of titanium materials within the medical and dental fields. Methods We used online searching tools including MEDLINE (PubMed), Embase, Cochrane Library, and Google Scholar by combining keywords such as “titanium implant toxicity,” “titanium implant corrosion,” “titanium implant allergy,” and “yellow nail syndrome.” Recently updated data has been collected and compiled into one of four categories: “the toxicity of titanium,” “the toxicity of titanium alloys,” “the toxicity of titanium implants,” and “diseases related to titanium.” Results Recent studies with regard to titanium toxicity have been increasing and have now expanded to the medical field in addition to the fields of environmental research and basic science. Problems that may arise in titanium-based dental implants include the generation of titanium and titanium alloy particles and ions deposited into surrounding tissues due to the corrosion and wear of implants, resulting in bone loss due to inflammatory reactions, which may lead to osseointegration failure of the dental implant. These titanium ions and particles are systemically deposited and can lead to toxic reactions in other tissues such as yellow nail syndrome. Additionally, implant failure and allergic reactions can occur due to hypersensitivity reactions. Zirconia implants can be considered as an alternative; however, limitations still exist due to a lack of long-term clinical data. Conclusions Clinicians should pay attention to the use of titanium dental implants and need to be aware of the problems that may arise from the use of titanium implants and should be able to diagnose them, in spite of very rare occurrence. Within the limitation of this study, it was suggested that we should be aware the rare problems of titanium toxicity.

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Section: Resultsmentioning

confidence: 99%

General review of titanium toxicity

et al. 2019

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“…The mice exhibit an altered microbiota associated with metabolic disorders characterized by insulin resistance, hyperlipidaemia and increased fat deposition, and all these markers were also observed in WT mice colonized with the gut microbiota of Tlr5-deficient mice [171]. By describing the key role of the local immune system in controlling the composition and activity of the microbiota, these data support the idea that the strong interactions [122,[126][127][128] ↗ expression of TLR (TLR3, TLR4, TLR7 and TLR10) [126,128] ↗ naïve T cells [122] Cytotoxicity and inflammation [122,123,125,129] ↗ pro-inflammatory cytokines (IL-6, TNF-α, IL1-β) [121-123, 127, 130-132] ↗ mature DC [122,131,132] Adjuvant [121,[130][131][132] ↗ chemokines secretion (IL-8 and CXCL1) ↙ activity (IL-8) [122,133] ↗ mast cell activation [134] Allergic response [134,135] ↗ co-stimulatory molecules (CD80 and CD86) [122,123,131,132] ↙ neutrophil and μɸ mobility [133] Tissue damage [124,133] ↗ MPO, MMP-9 and NET [124,136] ↗ neutrophil activity [124,136] NETosis: inflammation, necrosis and apoptosis [124] ↗ β-hexosaminidase release [134] inflammasome activation …”

Section: Microbiota-immune System Dysfunction In Chronic Diseases: Comentioning

confidence: 99%

Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health

2020

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Background: In food toxicology, there is growing interest in studying the impacts of foodborne nanoparticles (NPs, originating from food additives, food supplements or food packaging) on the intestinal microbiome due to the important and complex physiological roles of these microbial communities in host health. Biocidal activities, as described over recent years for most inorganic and metal NPs, could favour chronic changes in the composition and/or metabolic activities of commensal bacteria (namely, intestinal dysbiosis) with consequences on immune functions. Reciprocally, direct interactions of NPs with the immune system (e.g., inflammatory responses, adjuvant or immunosuppressive properties) may in turn have effects on the gut microbiota. Many chronic diseases in humans are associated with alterations along the microbiota-immune system axis, such as inflammatory bowel diseases (IBD) (Crohn's disease and ulcerative colitis), metabolic disorders (e.g., obesity) or colorectal cancer (CRC). This raises the question of whether chronic dietary exposure to inorganic NPs may be viewed as a risk factor facilitating disease onset and/or progression. Deciphering the variety of effects along the microbiota-immune axis may aid the understanding of how daily exposure to inorganic NPs through various foodstuffs may potentially disturb the intricate dialogue between gut commensals and immunity, hence increasing the vulnerability of the host. In animal studies, dose levels and durations of oral treatment are key factors for mimicking exposure conditions to which humans are or may be exposed through the diet on a daily basis, and are needed for hazard identification and risk assessment of foodborne NPs. This review summarizes relevant studies to support the development of predictive toxicological models that account for the gut microbiota-immune axis.

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“…Among the theoretical treatment strategies to reduce Covid19 cytokine storm, the employment of cytokine binding NPs can be considered. Diverse materials show incidental sticking ability for cytokines and chemokines, like CXCL18 and TNF-α (Song et al, 2004;Brown et al, 2010;Tsai et al, 2012;Batt et al, 2018). In principle, the administration in the bloodstream of NPs with specific adsorption of inflammatory molecules would help their clearance.…”

Section: Discussionmentioning

confidence: 99%