Tissue architecture in tumor initiation and progression

Almagro, Jorge; Messal, Hendrik A.; Elosegui‐Artola, Alberto; Rheenen, Jacco van; Behrens, Axel

doi:10.1016/j.trecan.2022.02.007

Cited by 43 publications

(34 citation statements)

References 101 publications

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“…Previous studies on the tumor microenvironment have confirmed that tumor-infiltrating immune cells play a regulatory role in tumor invasion and metastasis [ 37 – 39 ]. Our results indicated that the expression of most CXCLs in OC is were significantly correlated to one or more immune cells (including B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils, and dendritic cells).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of the CXCLs and Its Impact on the Immune Microenvironment in Ovarian Cancer

Xiong

Liu

2023

Disease Markers

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The chemokine (C-X-C motif) ligand (CXCL) family in tumor tissue is closely related to tumor growth, metastasis, and survival. However, the differential expression profile and prognostic value of the CXCLs in ovarian cancer (OC) have not been elucidated. Therefore, we studied the expression levels and mutations of CXCLs in OC patient in TCGA and various public databases. The expression differences of CXCLs in OC cancer tissues and normal tissues were compared through the Gene Expression Profiling Interactive Analysis (GEPIA) database. The effect of CXCLs on OC prognosis was analyzed using the Kaplan-Meier curves in GEPIA database. The impact of CXCLs on immune infiltration and clinicopathological outcomes in OC was assessed using the TIMER algorithm. Compared with normal tissues, we found that eight CXCLs were significantly differentially expressed in OC. The expression levels of CXCL9 ( P = 0.0201 ), CXCL11 ( P = 0.0385 ), and CXCL13 ( P = 0.0288 ) were significantly associated with tumor stage. CXCL13 was the only gene that significantly affected both disease-free survival (DFS) and overall survival (OS) in OC, and higher CXCL13 transcript levels implied longer DFS and OS. Although there was no significant impact on DFS, CXCL10 ( P = 0.0079 ) and CXCL11 ( P = 0.0011 ) expression levels had a significant effect on OS in OC. At the same time, CXCLs were significantly associated with several immune-infiltrating cells in OC tissues. The CXCLs were significantly associated with one or more immune-infiltrating cells in OC tissue. CXCL13 was differentially expressed in OC and significantly affected the prognosis of patients and was a potential marker of OC prognosis.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of the CXCLs and Its Impact on the Immune Microenvironment in Ovarian Cancer

Xiong

Liu

2023

Disease Markers

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“…The perivascular niche allows cancer cells better access to oxygen and nutrients, and provides anchorage to the vascular basement membrane for survival and outgrowth 86 . Less frequently noted in the brain is the tight, spheroidal growth that HER2BC cells assume soon after infiltration, which is the archetypal growth pattern in a majority of primary tumors 36, 87 . These brain metastatic tumor architectures are respectively associated with infiltrative (TNBC) or segregated (HER2BC) interfaces with the TME.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, the spatial features of brain metastatic colony formation and their role in disease progression are unknown. The tumor growth and stromal crosstalk are functionally embedded in tumor architecture, in that the spatial features of a colony can be both cause and consequence of various other determinants (e.g., immune infiltration) of tumor development 36 .…”

Section: Introductionmentioning

confidence: 99%

Distinct tumor architectures for metastatic colonization of the brain

Gan

Macalinao

Shahoei

et al. 2023

Preprint

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Brain metastasis is a dismal cancer complication, hinging on the initial survival and outgrowth of disseminated cancer cells. To understand these crucial early stages of colonization, we investigated two prevalent sources of cerebral relapse, triple-negative (TNBC) and HER2+ breast cancer (HER2BC). We show that these tumor types colonize the brain aggressively, yet with distinct tumor architectures, stromal interfaces, and autocrine growth programs. TNBC forms perivascular sheaths with diffusive contact with astrocytes and microglia. In contrast, HER2BC forms compact spheroids prompted by autonomous extracellular matrix components and segregating stromal cells to their periphery. Single-cell transcriptomic dissection reveals canonical Alzheimer's disease-associated microglia (DAM) responses. Differential engagement of tumor-DAM signaling through the receptor AXL suggests specific pro-metastatic functions of the tumor architecture in both TNBC perivascular and HER2BC spheroidal colonies. The distinct spatial features of these two highly efficient modes of brain colonization have relevance for leveraging the stroma to treat brain metastasis.

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“…The oncogenic transformation of an epithelial tissue occurs within spatial constraints imposed by cell neighbours and the ECM [ 56 ]. It is therefore important to determine how oncogenic RAS-induced changes to actomyosin contractility, cell mechanics, substrate adhesion, and mechanotransduction in individual cells play out at the level of the collective or tissue.…”

Section: Oncogenic Ras (Mis)shapes Tissuesmentioning

confidence: 99%