Tissue Bioengineering

Abstract

laucoma comprises a heterogeneous group of disorders, the final common pathways of which result in the death of retinal ganglion cells (RGC) and subsequent characteristic patterns of visual field loss and excavation of the optic nerve head. Those glaucomas in which elevated intraocular pressure (IOP) predominate are characterized by dysfunction of the trabecular meshwork, resulting in increased resistance to aqueous outflow. Non-pressure-dependent mechanisms remain poorly delineated and may consist of cardiovascular and local ischemic conditions, autoimmune and connective tissue disorders, and genetic predisposition to retinal ganglion cell death.

Human amnion membrane: Potential applications in oral and periodontal field

“…[5960] In addition, their mechanical properties should include permeability, stability, elasticity, flexibility, plasticity, and resorbability at a rate congruent with tissue replacement. [61] Scaffolds should also allow cell adhesion and the potential for delivery of biomodulatory agents such as growth factors and genetic materials.…”

Bio-Fabrication of Human Amniotic Membrane Zinc Oxide Nanoparticles and the Wet/Dry HAM Dressing Membrane for Wound Healing

“…Human amniotic membrane was previously treated with 1 percent Trypsin/EDTA, which eliminated epithelial and mesenchymal cells while keeping the basal membrane and extracellular matrix intact. The latter was mechanically powerful, had anti-inflammatory, anti-microbial, anti-fibrotic, anti-scarring, and biocompatibility properties, but had only a minor immunogenicity ( Rieder et al, 2004 ; Young et al, 2005 ; Baguneid et al, 2006 ; Bhatia et al, 2007 ; Lim et al, 2009 ; Peter Crapo et al, 2011 ; Caruso et al, 2013 ; Mamede et al, 2015 ; Sanluis-Verdes et al, 2015 ; Zhang et al, 2016 ). The protection of essential molecules such as anti-inflammatory cytokines, growth factors, and extracellular matrix factors, as well as the structural integrity of the non-cellular matrix, should be the focus of future advances in the processing and stabilization of HAM for wound dressing.…”

First steps for the development of silk fibroin-based 3D biohybrid retina for age-related macular degeneration (AMD)

“…First of all, the material with which the scaffold is built must comply with the biocompatibility property, to avoid any toxic response or immune reaction [147]. Scaffolds must also be ultrathin (few micrometers thick), implantable, and flexible to avoid tissue damage; but mechanically strong to resist.…”