Tissue Cadmium Accumulation is Associated with Basal Metabolic Rate in Mice

Maciak, Sebastian; Włostowski, Tadeusz; Salińska, Aneta; Bonda-Ostaszewska, Elżbieta

doi:10.1007/s12011-011-9061-6

Cited by 7 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, Cd accumulation in this study was positively associated with iron concentration—a metabolically important element (Maciak et al. ). Both Cd and Fe use the same DMT1 transporter in apical membrane of enterocytes for cellular uptake (Tallkvist et al.…”

Section: Metabolic Rate As a Main Cause Of Cell Conditionsupporting

confidence: 52%

“…Chronic exposure to any of these produces damage primarily to the metabolically active tissues (e.g., liver, kidneys, and intestines), including cellular degeneration and apoptosis, DNA mutations, interstitial inflammation, and whole organ dysfunction (e.g., Maciak et al. ; Salińska et al. ).…”

Section: Metabolic Rate As a Main Cause Of Cell Conditionmentioning

confidence: 99%

“…). Moreover, Maciak et al () showed that Cd‐induced cellular toxicity in metabolically active organs strongly depends on their metabolic rates. Mice artificially selected for high basal metabolic rate accumulated two times more cadmium in the liver, kidneys, and duodenum compared to mice with lower BMR (Maciak et al.…”

Section: Metabolic Rate As a Main Cause Of Cell Conditionmentioning

confidence: 99%

“…Mice artificially selected for high basal metabolic rate accumulated two times more cadmium in the liver, kidneys, and duodenum compared to mice with lower BMR (Maciak et al. ). Additionally, Cd accumulation in this study was positively associated with iron concentration—a metabolically important element (Maciak et al.…”

Section: Metabolic Rate As a Main Cause Of Cell Conditionmentioning

confidence: 99%

“…Influence of toxins, heavy metals, and other mutagenic factors on cellular DNA is considered a main cause of tumor development (Voth and Ballard 2005;Khlifi and Hamza-Chaffai 2010;Włostowski et al 2010). Chronic exposure to any of these produces damage primarily to the metabolically active tissues (e.g., liver, kidneys, and intestines), including cellular degeneration and apoptosis, DNA mutations, interstitial inflammation, and whole organ dysfunction (e.g., Maciak et al 2011b;Sali nska et al 2012). Although epidemiological, cell culture, and animal experimental studies have shown an increased cancer incidence associated with heavy metals intoxication (Sunderman 1984;Trott et al 1995;Oller et al 1997;Salnikow and Zhitkovich 2008), the mechanisms of carcinogenesis remain poorly understood.…”

Section: Toxicity Metabolism and Cancerogenesismentioning

confidence: 99%

See 4 more Smart Citations

Cell size and cancer: a new solution to Peto's paradox?

Maciak

Michalak

2014

Evolutionary Applications

Self Cite

View full text Add to dashboard Cite

Cancer, one of the leading health concerns for humans, is by no means a human-unique malady. Accumulating evidence shows that cancer kills domestic and wild animals at a similar rate to humans and can even pose a conservation threat to certain species. Assuming that each physiologically active and proliferating cell is at risk of malignant transformation, any evolutionary increase in the number of cells (and thus body mass) will lead to a higher cancer frequency, all else being equal. However, available data fail to support the prediction that bigger animals are affected by cancer more than smaller ones. The unexpected lack of correlation between body size (and life span) and cancer risk across taxa was dubbed Peto's paradox. In this perspective, several plausible explanations of Peto's paradox are presented, with the emphasis on a largely underappreciated relation of cell size to both metabolism and cell division rates across species, which we believe are key factors underlying the paradox. We conclude that larger organisms have bigger and slowly dividing cells with lower energy turnover, all significantly reducing the risk of cancer initiation. Solving Peto's paradox will enhance our understanding the evolution of cancer and may provide new implications for cancer prevention and treatment.

show abstract

Section: Metabolic Rate As a Main Cause Of Cell Conditionsupporting

confidence: 52%

Section: Metabolic Rate As a Main Cause Of Cell Conditionmentioning

confidence: 99%

Section: Metabolic Rate As a Main Cause Of Cell Conditionmentioning

confidence: 99%

Section: Metabolic Rate As a Main Cause Of Cell Conditionmentioning

confidence: 99%