Tissue Development and Mechanical Property in the Regenerated-Cartilage Tissue

Omata, Seiji; Sawae, Yoshinori; Murakami, Teruo

doi:10.5772/51443

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2017

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“…Articular cartilage is an avascular connective tissue with remarkable biomechanical properties. The function of articular cartilage is reducing the friction among bones in joints via joint lubrication and smoothness of surfaces, distributing loads across the joint surface and shock absorption [4,18]. The main components of extracellular matrix are aggrecan and type II collagen which are most notably responsible for cartilage compressive and tensile resistance [22].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen peroxide induced oxidative damage on mechanical properties of the articular cartilage

Çiçek

2017

Acta Biologica Hungarica

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Articular cartilage has unique mechanical and physicochemical properties which are responsible for its load carrying capabilities. This work investigates the effects of hydrogen peroxide induced oxidative damage on mechanical properties of articular cartilage. Bovine articular cartilage was exposed to hydrogen peroxide for a week. Dynamic and static mechanical tests applied to calculate articular cartilage compressive modulus. We observed higher control curve slopes than that of hydrogen peroxide curves which account for lesser stiffness values in the exposed articular cartilage. For the instantaneous experiments, results were statistically significant (p = 0.01, p < 0.05). Here report that hydrogen peroxide induced oxidative damage causes reduction in the stiffness of the articular cartilage.

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Section: Introductionmentioning

confidence: 99%

Hydrogen peroxide induced oxidative damage on mechanical properties of the articular cartilage

Çiçek

2017

Acta Biologica Hungarica

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show abstract

Tissue Development and Mechanical Property in the Regenerated-Cartilage Tissue

Cited by 1 publication

References 50 publications

Hydrogen peroxide induced oxidative damage on mechanical properties of the articular cartilage

Hydrogen peroxide induced oxidative damage on mechanical properties of the articular cartilage

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