Tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol and its metabolites in pigs after oral exposure

Xie, Shuyu; Cui, Yonghui; Yang, Yujuan; Meng, Kuiyu; Pan, Yuanhu; Liu, Zhenli; Chen, Dongmei

doi:10.1016/j.chemosphere.2020.126016

Cited by 14 publications

(11 citation statements)

References 40 publications

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“…55,56 After the ECF method was phased out in 2003, telomerization became an important synthesis method in fluorochemical production. 57 Therefore, factor 5 represents the telomerization fluorochemistry.…”

Section: Resultsmentioning

confidence: 99%

“…Factor 5 has a high load of FHpPA. FHpPA is a typical transformation product of 8:2 fluorotelomer alcohol, which is an important raw material intermediate in fluorochemical production. , After the ECF method was phased out in 2003, telomerization became an important synthesis method in fluorochemical production . Therefore, factor 5 represents the telomerization fluorochemistry.…”

Section: Results and Discussionmentioning

confidence: 99%

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Occurrence, Temporal Variation (2010–2018), Distribution, and Source Appointment of Per- and Polyfluoroalkyl Substances (PFAS) in Mollusks from the Bohai Sea, China

Meng

Wang

et al. 2021

ACS EST Water

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Per- and polyfluoroalkyl substances (PFAS) including legacy and emerging compounds have been widely detected in various environmental media and have attracted a significant amount of research and regulatory attention. Aquatic environments such as seawater are important PFAS sinks due to the strong stability and water solubility of PFAS. In this study, the occurrence, temporal variation, and source appointment of 17 legacy and 16 emerging PFAS in seven different mollusks from nine cities around the Bohai Sea, China, were investigated from 2010 to 2018. Significantly higher concentrations of legacy PFAS compared to those of emerging PFAS indicate that legacy PFAS products, including perfluorooctane sulfonic acid and perfluorooctanoic acid, are still widely used in China. However, the decreasing trend of the legacy PFAS concentrations in mollusks after 2015 indicate that these products are gradually being withdrawn from the market due to China’s implementation of the Stockholm Convention. A positive matrix factorization was used to identify six primary pollution sources including electrochemical fluorination processes, domestic sewage discharge, metal plating, food packaging, the fluorochemical industry, and the fluoropolymer industry. Among these sources, the fluoropolymer industry is the largest contributor to environmental PFAS, accounting for 68% of the total pollution in this region.

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Section: Resultsmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Occurrence, Temporal Variation (2010–2018), Distribution, and Source Appointment of Per- and Polyfluoroalkyl Substances (PFAS) in Mollusks from the Bohai Sea, China

Meng

Wang

et al. 2021

ACS EST Water

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“…46 7:3 FTCA is an intermediate environmental degradation product from fluorotelomer alcohols (FTOH), whose final degradation products are PFCAs. 80 It has been recently detected in human tissues and wildlife. 46,[81][82][83][84][85][86][87] In eggs of osprey (Pandion haliaetus), tawny owl (Strix aluco) and common kestrel (Falco tinnunculus), this compound ranged from <0.24 (LOD) to 2.7 ng g -1 much higher concentrations than those found in kittiwake eggs reported here.…”

Section: Emerging Pfas In Females and Their Eggsmentioning

confidence: 99%

A Bad Start in Life? Maternal Transfer of Legacy and Emerging Poly- and Perfluoroalkyl Substances to Eggs in an Arctic Seabird

Jouanneau

Léandri‐Breton

Corbeau

et al. 2021

Environ. Sci. Technol.

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In birds, maternal transfer is a major exposure route for several contaminants, including polyand perfluoroalkyl substances (PFAS). Little is known, however, about the extent of the transfer of the different PFAS compounds to the eggs, especially for alternative fluorinated compounds.In the present study we measured legacy and emerging PFAS, including Gen-X, ADONA and F-53B, in the plasma of pre-laying black-legged kittiwake females breeding in Svalbard and the yolk of their eggs. We aimed to 1/ describe the contaminant levels and patterns in both females and eggs, and 2/ investigate the maternal transfer, i.e. biological variables and the relationship between the females and their eggs for each compound. Contamination of both females and eggs were dominated by linPFOS then PFUnA or PFTriA. We notably found 7:3 fluorotelomer carboxylic acid -a precursor of long-chain carboxylates -in 84% of the egg yolks, and provide the first documented finding of ADONA in wildlife. Emerging compounds were all below the detection limit in female plasma. There was a linear association between females and eggs for most of the PFAS. Analyses of maternal transfer ratios in females and eggs suggest that the transfer is increasing with PFAS carbon chain length, therefore the longest chain perfluoroalkyl carboxylic acids (PFCAs) were preferentially transferred to the eggs. The mean ∑PFAS in the second-laid eggs was 73% of that in the first-laid eggs. Additional effort on assessing the outcome of maternal transfers on avian development physiology is essential, especially for PFCAs and emerging fluorinated compounds which are under-represented in experimental studies. SYNOPSISInvestigating the maternal transfer of PFAS in avian top predators is an essential steps in understanding the adverse effects of these compounds on wildlife.

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“…PFOA has been detected in house dust, [ 4 ] surface and drinking water, [ 5 , 6 ], indoor and outdoor air [ 7 ], and animal tissues [ 8 , 9 ]. Humans are exposed to PFOA through diet, primarily eggs, fish products, poultry products, cereals, vegetables and drinking water, inhalation of dust particles, and in commercial products [ 5 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

Rashid

Ahmad

Irudayaraj

2020

Toxics

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Perfluorooctanoic acid (PFOA) has been implicated in various toxicities including neurotoxicity, genotoxicity, nephrotoxicity, epigenetic toxicity, immunotoxicity, reproductive toxicity, and hepatotoxicity. However, information on the accumulation of PFOA in the intestine and its toxic effects on intestinal epigenetics and tight junction (TJ) genes is sparse. CD1 mice were dosed with PFOA (1, 5, 10, or 20 mg/kg/day) for 10 days, and its accumulation and induced alterations in the expression of epigenetic and tight junction genes in the small intestine and colon were evaluated using LC–MS and qPCR techniques. PFOA reduced the expression levels of DNA methyltransferases (Dnmt1, Dnmt3a, Dnmt3b) primarily in the small intestine whereas, in the colon, a decrease was observed only at high concentrations. Moreover, ten-eleven translocation genes (Tet2 and Tet3) expression was dysregulated in the small intestine, whereas in the colon Tets remained unaffected. The tight junction genes Claudins (Cldn), Occludin (Ocln), and Tight Junction Protein (Tjp) were also heavily altered in the small intestine. TJs responded differently across the gut, in proportion to PFOA dosing. Our study reveals that PFOA triggers DNA methylation changes and alters the expression of genes essential for maintaining the physical barrier of intestine, with more profound effects in the small intestine compared to the colon.

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Tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol and its metabolites in pigs after oral exposure

Cited by 14 publications

References 40 publications

Occurrence, Temporal Variation (2010–2018), Distribution, and Source Appointment of Per- and Polyfluoroalkyl Substances (PFAS) in Mollusks from the Bohai Sea, China

Occurrence, Temporal Variation (2010–2018), Distribution, and Source Appointment of Per- and Polyfluoroalkyl Substances (PFAS) in Mollusks from the Bohai Sea, China

A Bad Start in Life? Maternal Transfer of Legacy and Emerging Poly- and Perfluoroalkyl Substances to Eggs in an Arctic Seabird

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

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