Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus×O. caureus) after a single oral administration in freshwater and seawater at 28 °C

Feng, Jingbin; Jia, Xiaoping; Zhao, Dong-Hao

doi:10.1016/j.aquaculture.2008.01.002

Cited by 58 publications

(66 citation statements)

References 15 publications

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“…The plasma drug elimination was relatively slower in grouper than in tilapia. Nevertheless, this was not consistent with our previous conclusion, namely the elimination of florfenicol was more rapid in seawater fish than in freshwater fish (Feng, Jia & Li ). The possible cause was that the strong re‐absorption occurring from 12 to 24 h decelerated the drug elimination in seawater grouper, whereas the weak re‐absorption occurring from 18 to 24 h had a minor effect on the elimination in freshwater tilapia.…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange‐spotted grouper (Epinephelus coioides) after oral administration

Dr²,

Zhong

et al. 2015

Journal of Fish Diseases

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Pharmacokinetics and elimination of florfenicol and florfenicol amine in grouper held in sea water at 23.3 AE 0.8°C were studied using HPLC method after they were given a single peroral dose of florfenicol at 24 mg kg À1 body weight. Florfenicol was rapidly absorbed from intestine and distributed extensively to all the tissues examined. The maximum concentrations (C max , lg g À1 or lg mL À1 ) in plasma and tissues were observed at 2-6 h (the time to reach maximum concentration, T max ) except for bile (T max = 24 h) and were in the order of intestine (52.02 AE 25.07) > bile (49.41 AE 28.16) > gill (45.12 AE 11.10) > plasma (28.28 AE 5.43) > liver (21.97 AE 12.08) > muscle (21.63 AE 6.12) > kidney (20.88 AE 11.28) > skin (19.10 AE 5.88). The drug distribution level was higher in plasma than in extravascular tissues except for bile, based on the ratios of the area under concentration-time curve between tissue and plasma (AUC tissue/plasma ). The elimination of florfenicol was rapid in fish, and the corresponding half-lives (T 1/2b ) in the order of magnitude were bile (13.92 h) > muscle or liver (12.31 h) > skin (11.77 h) > plasma (11.57) > gill (11.04 h) > intestine (10.55 h) > kidney (10.05 h). The delayed T max , lower C max and longer T 1/2b for florfenicol amine compared with florfenicol were measured in grouper.

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Section: Discussioncontrasting

confidence: 99%

“…It was concluded that florfenicol and its metabolite in seawater tilapia may be mainly excreted by gill (Feng et al . ). In this study, the much low AUC and C max of florfenicol amine in gill indicated only the minor elimination of the metabolite through gill.…”

Section: Discussionmentioning

confidence: 97%

Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange‐spotted grouper (Epinephelus coioides) after oral administration

Dr²,

Zhong

et al. 2015

Journal of Fish Diseases

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“…In this study, the results showed that FF was absorbed rapidly in yellow catfish after p.o. administration at a dose of 10 mg/kg at 25 C. The mean values of C max and T max in the plasma of yellow catfish were 2.35 µg/mL and 7.25 h, respectively, which were lower and earlier than those in cod (12.40 µg/mL and 9 h after 10 mg/kg of oral doses, Samuelsen et al ), Korean catfish (9.59 µg/mL and 8 h after 10 mg/kg of oral doses, Park et al ), tilapia (4.46 µg/mL and 12 h after 10 mg/kg of oral doses, Feng et al ), and channel catfish, I . punctatus (7.61 ± 0.87 µg/mL and 9.20 ± 2.53 h after after 10 mg/kg of oral doses, Gaunt et al ).…”

Section: Discussionmentioning

confidence: 95%

Pharmacokinetics of Florfenicol after Oral Administration in Yellow Catfish, Pelteobagrus fulvidraco

Yang

Xie

et al. 2013

J World Aquaculture Soc

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The pharmacokinetics of florfenicol (FF) and its metabolite, florfenicol amine (FFA), were investigated after doses of 10 mg/kg/day were administered orally per os (p.o.) on a single day or on three consecutive days in yellow catfish, Pelteobagrus fulvidraco, raised in water temperatures of 25 C. After a single dose p.o. was administered, the apparent volume of distribution at steady state (Vdss) of FF was computed to be 2.52 L/kg. The Tmax values were in the following order: liver (1.82 h) < kidney (2.26 h) < skin (6.15 h) < muscle (6.32 h) < plasma (7.25 h). These results show that FF and FFA accumulated rapidly in the kidney and liver. The t1/2β values in plasma, muscle, skin, liver, and kidney were 9.63, 15.75, 14.44, 11.55, and 15.75 h, respectively, for FF and 21.66, 15.07, 17.33, 26.65, and 30.13 h, respectively, for FFA. After a single p.o. dose was administered on three consecutive days, the t1/2β values of FF and FFA in skin‐on muscle were 17.12 and 13.55 h, respectively. The total concentrations of FF and FFA in skin‐on muscle 1, 3, and 5 d after the last administration were 3.39, 0.5, and 0.062 µg/g, respectively.

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“…, 1994, 1996), red pacu (Lewbart et al. , 2005), tilapia (Feng et al. , 2008; Feng & Jia., 2009), cod (Hansen & Horsberg, 2000; Samuelsen et al.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of florfenicol in crucian carp (Carassius auratus cuvieri) after a single intramuscular or oral administration

Zhao

Zhang

Bai

et al. 2011

Vet Pharm & Therapeutics

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The pharmacokinetics of florfenicol (FF) was studied in plasma after a single dose (40 mg/kg) of intramuscular (i.m.) or oral gavage (p.o.) administration to crucian carp (Carassius auratus cuvieri) in freshwater at 25 °C. Ten fish per sampling point were examined after treatment. The data were fitted to two-compartment open models follow both routes of administration. The estimates of total body clearance (CL(b) ), volume of distribution (V(d) /F), and absorption half-life (T(1/2(ka)) ) were 0.067 L/h/kg and 0.145 L/h/kg, 2.21 L/kg and 1.04 L/kg, 2.75 and 1.54/h following i.m. and p.o. administration, respectively. After i.m. injection, the elimination half-life (T(1/2(β)) ) was calculated to be 38.2h, the maximum plasma concentration (C(max) ) to be 16.82 μg/mL, the time to peak plasma FF concentration (T(max) ) to be 1.50 h, and the area under the plasma concentration-time curve (AUC) to be 597.4 μg/mL·h. Following p.o. administration, the corresponding estimates were 2.17 h, 29.32 μg/mL, 1.61 h, and 276.1 μg/mL·h.

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Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus×O. caureus) after a single oral administration in freshwater and seawater at 28 °C

Cited by 58 publications

References 15 publications

Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange‐spotted grouper (Epinephelus coioides) after oral administration

Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange‐spotted grouper (Epinephelus coioides) after oral administration

Pharmacokinetics of Florfenicol after Oral Administration in Yellow Catfish, Pelteobagrus fulvidraco

Pharmacokinetics of florfenicol in crucian carp (Carassius auratus cuvieri) after a single intramuscular or oral administration

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