Tissue Distribution and Redox Status Coenzyme Q10 After Intravenous Administration of Ubiquinol to Rat

Shapoval, N. S.; Оболенская, Ольга Николаевна; Kalenikova, E. I.; Gorodetskaya, E. A.; Медведев, О. С.

doi:10.1097/01.hjh.0000539397.97203.46

Cited by 2 publications

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“…The intravenous form provides an instant increase in plasma level of CoQ 10 and gradual replenishment of its tissue level. This fact is demonstrated in a rapid and long-lasting correction of the redox imbalance in oxidative stress and accompanying pathologies (Kalenikova et al 2015;Shapoval et al 2018).…”

Section: Introductionmentioning

confidence: 99%

“…However, it should be noted that oral CoQ 10 administration is characterized by rather low bioavailability at the level of only 0.1-3% (Kharitonova et al 2013). In this connection, soluble form of ubiquinol for intravenous administration was developed to overcome the problem of its low bioavailability (Kharitonova et al 2013;Kalenikova et al 2017;Shapoval et al 2018). The intravenous form provides an instant increase in plasma level of CoQ 10 and gradual replenishment of its tissue level.…”

Section: Introductionmentioning

confidence: 99%

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Ubiquinol ameliorates endothelial dysfunction and increases expression of miRNA-34a in a rat model of pulmonary hypertension

Kuropatkina¹,

Pankova²,

Medvedeva³

et al. 2021

RRP

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Introduction: In this research, we evaluate the effect of intravenously administrated solubilized ubiquinol on 4-week monocrotalin-induced pulmonary hypertension (PH) in rats. Materials and methods: To reproduce the model, some male Wistar rats were subcutaneously injected with alcohol solution of monocrotaline 60 mg/kg and the rest – with alcohol solution (Control). Those with monocrotaline (MCT) were divided into 3 groups. They underwent intravenous administration of 1% ubiquinol solution 30 mg/kg (MCT-Ubiquinol), the vehicle (MCT-Vehicle) and saline (MCT-saline) three times on days 7, 14 and 21, depending on the group. The hemodynamic parameters were measured in anesthetized rats on day 29. Right ventricle hypertrophy, pulmonary arteries reactivity and expression of miRNA-21 and miRNA-34a were estimated after euthanasia. Results and discussion: All MCT-groups demonstrated an increase in right ventricle systolic pressure and hypertrophy in comparison with the control group. An increase in lung weight was shown in MCT-Vehicle and MCT-Saline; however, the MCT-Ubiquinol indicators did not differ from those of the Control. There was an increased vasodilatation response to acetylcholine at concentrations of 1*10-6M and 1*10-5M in MCT-Ubiquinol in contrast to the other two MCT-groups. A significantly lower level of expression of miRNA-34a was observed in MCT-Ubiquinol. Conclusion: Our findings suggest that a triple ubiquinol injection influences pulmonary changes and endothelium-depended vasodilatation, which contributes to pulmonary vascular tone and reactivity. A decrease in miRNA-34a expression in MCT-Ubiquinol group demonstrates the ubiquinol anti-inflammatory properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%