Tissue distribution, bioaccumulation characteristics and health risk of antibiotics in cultured fish from a typical aquaculture area

The rearing of fish in intensive systems reduces their immunity leading to eruption of diseases, consequently prompting the use of antibiotics. Antibiotics are currently used in cultured fish globally to treat/prevent diseases. On the one hand, antibiotics used in aquaculture help to improve fish health by killing or inhibiting pathogenic bacteria proliferation. However, on the other hand, they cause multiple side effects. To date, information on systemic effects of antibiotics in cultured fish is scattered and their potential human health risk remains elusive. This review critically analyses and discusses the available information in the literature on the positive and negative effects of antibiotics in cultured fish and their potential human health risk via fish consumption. The review found 44 different antibiotics dominated by oxytetracycline were studied in various fish species worldwide. Antibiotics used in global aquaculture either decrease or increase fish growth and survival rates. They induce oxidative stress, which affect antioxidant and detoxification responses and cause host–microbiota dysbiosis. These changes compromise the fish immunity system, which ultimately lead to cellular damage. The toxicities generated inhibit the fish aerobic glycolysis, suppress lipogenesis and fatty acid β‐oxidation while increase energy demand by initiating gluconeogenesis and anaerobic glycolysis. Consumption of fish treated with antibiotics causes human health risk. Future studies are required on agents to restore dysfunctions induced by antibiotics in cultured fish, while attempts to limit their utilisation in aquaculture production are underway. [Correction added on 21 November 2020, after first online publication: The abstract has been amended to clarify the scope of the review.]

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“…2016; Chen et al . 2018) and markets (Olatoye & Basiru 2013; Adel et al . 2017), other seafood such as shrimps (Sun et al .…”

Section: Potential Human Health Risk Via Fish Consumptionmentioning

confidence: 99%

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Limbu

Chen

Zhang

et al. 2020

Reviews in Aquaculture

141

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“…2,3 Tetracycline antibiotics are the second largest class of antibiotics in the world and are used in large quantities. 4 Due to the biological toxicity of TC, its metabolites are difficult to degrade in the environment and organism. 5,6 The potential hazards of TC and its residues to the water environment have become a problem that cannot be ignored.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Cu₂O@TiOF₂/TiO₂and its photocatalytic degradation of tetracycline hydrochloride wastewater

et al. 2019

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“…Recently, with agricultural non-point source pollution worsening and fishermen’s unscientific management, polluted water from livestock farms, farmland, and even chemical product factories has entered aquaculture through polluted river water [ 5 ]. Previous research on pollutants of freshwater fish mostly focused on antibiotics [ 6 , 7 ] and pesticides [ 8 , 9 ]. However, heavy metals and metalloids are also common pollutants in water or other environmental media and have attracted considerable attention due to their persistence, recalcitrance, bioaccumulation and potential toxicity, especially in some developing countries like China, Pakistan and India [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Toxic Metal Distribution Characteristics and Health Risk between Cultured and Wild Fish Captured from Honghu City, China

Zhang

Zhu

Liu

et al. 2018

IJERPH

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Honghu Lake, which listed in the “Ramsar Convention”, is the seventh largest freshwater lake in China and is regarded as one of the biggest freshwater product output areas in China. The toxic element distribution in cultured and wild fish and the corresponding health risks through fish consumption from Honghu area were investigated. The mean concentration in the muscle of cultured and wild fish (Carassius auratus and Ctenopharyngodon idellus) decreased in the order: Zn (18.94) > Cu (0.8489) > Cr (0.2840) > Pb (0.2052) and Zn (16.30) > Cr (1.947) > Cu (0.4166) > Pb (0.0525) > Cd (0.0060) (mean; mg/kg, wet weight). Scales (Multi factor pollution index (MPI) = 3.342) and the liver (MPI = 1.276) were regarded as the main accumulation tissues for cultured fish, and the bladder (MPI = 0.640) and intestine (MPI = 0.477) were regarded as the main accumulation tissues for wild fish. There were no obvious health risks associated with the consumption of cultured and wild fish based on the calculated results of the target hazard quotient (THQ), carcinogenic risk (CR), and estimated weekly intake (EWI). Pb and Cr were recognized as the major health risk contributors for inhabitants through wild and cultured fish consumption. Cultured fish had a greater health risk than wild fish based on the calculation results of THQ and CR. Muscle consumption resulted in more health risks than mixed edible tissues for cultured fish, but for wild fish, the conclusion was the opposite. Mixed fish (cultured:wild = 1:1) muscle consumption had relatively lower risks than the consumption of cultured or wild fish muscle separately. Consuming no more than 465 g/day (wet wt) of cultured fish muscle, 68 g/day (wet wt) of wild fish muscle, 452 g/day (wet wt) of mixed cultured fish edible tissues or 186 g/day (wet wt) of mixed wild fish edible tissues from the Honghu area can assure human health.

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Tissue distribution, bioaccumulation characteristics and health risk of antibiotics in cultured fish from a typical aquaculture area

Cited by 185 publications

References 31 publications

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Preparation of Cu₂O@TiOF₂/TiO₂and its photocatalytic degradation of tetracycline hydrochloride wastewater

Comparison of Toxic Metal Distribution Characteristics and Health Risk between Cultured and Wild Fish Captured from Honghu City, China

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Tissue distribution, bioaccumulation characteristics and health risk of antibiotics in cultured fish from a typical aquaculture area

Cited by 185 publications

References 31 publications

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Preparation of Cu2O@TiOF2/TiO2and its photocatalytic degradation of tetracycline hydrochloride wastewater

Comparison of Toxic Metal Distribution Characteristics and Health Risk between Cultured and Wild Fish Captured from Honghu City, China

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Preparation of Cu₂O@TiOF₂/TiO₂and its photocatalytic degradation of tetracycline hydrochloride wastewater