Tissue distribution, kinetics, and biologic half-life of Mg<sup>28</sup> in the dog

Lazzara, Richard; Hyatt, Kenneth H.; Love, William D.; Cronvich, J. A.; Burch, George E.

doi:10.1152/ajplegacy.1963.204.6.1086

Cited by 15 publications

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“…It is probable that variations in average erythrocyte age among the subjects of this study and the varying effects of therapy on erythrocyte turnover are primarily responsible for the unpredictable effects of therapy on erythrocyte magnesium concentrations, masking any effects thyroid dysfunction and its correction may have on tissue magnesium stores. Since skeletal muscle magnesium also exchanges very slowly (22,23), it is possible that skeletal muscle analyses, even if feasible in large groups of patients with thyroid dysfunction, might not adequately reflect body magnesium stores.…”

Section: Discussionmentioning

confidence: 99%

Plasma and Erythrocyte Magnesium in Thyroid Disease

Řízek

Dimich

Wallach

1965

The Journal of Clinical Endocrinology & Metabolism

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Serial determinations of plasma and erythrocyte magnesium concentrations were made before and during therapy in 13 hyperthyroid and 12 hypothyroid patients. Plasma magnesium concentrations were initially subnormal in 7 hyperthyroid patients and returned to normal as a response to antithyroid therapy became manifest. In 6 normomagnesemic hyperthyroid patients, plasma magnesium concentrations also tended to increase with therapy. Six hypothyroid patients had supranormal plasma magnesium concentrations prior to therapy. These returned to normal with treatment in 5 patients, but one subject showed a persistent elevation of the plasma magnesium concentration despite a satisfactory response to therapy. A decrease in plasma magnesium concentrations also occurred in the 6 normomagnesemic hypothyroid patients. Pretreatment erythrocyte magnesium concentrations were subnormal in 6 hyperthyroid and one hypothyroid patient. The response of erythrocyte magnesium concentrations to therapy was unpredictable, and increased, decreased or remained unchanged without relation to thyroid status or plasma magnesium concentrations. Evidence suggests that these alterations in extracellular magnesium concentrations in thyroid disease result either from a defect in magnesium balance or in magnesium distribution. Since the erythrocyte magnesium concentration appears to be a poor indicator of body magnesium in thyroid disease, resolution of this problem must await the development of precise measurements of total and available tissue magnesium concentrations. (J Clin Endocr 25: 350, 1965) P REVIOUS studies of the relation between the thyroid gland and magnesium have included observations on both the effects of magnesium on thyroid function and the effects of the thyroid on magnesium metabolism. Corradino and Parker (1) found an increased thyroid size in magnesium-deficient rats. In a preliminary report, Neguib (2) observed that magnesium administration decreased the thyroid size and the clinical manifestations of three hyper-

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Section: Discussionmentioning

confidence: 99%

Plasma and Erythrocyte Magnesium in Thyroid Disease

Řízek

Dimich

Wallach

1965

The Journal of Clinical Endocrinology & Metabolism

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“…The majority of a mammal's readily exchangeable Mg is stored within cells, although cells are not uniform in their Mg concentrations. After rapid intravenous administration to dogs, the peak tissue Mg concentration and rate of exchange between intracellular and extracellular compartments vary widely among different organs . This wide variation in exchange rates (and abrupt translocation in some disease states) limits the precision with which extracellular concentrations can be used to evaluate whole‐body or intracellular Mg status.…”

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confidence: 99%

Hypomagnesemia in Brachycephalic Dogs

Mellema

Hoareau

2014

Veterinary Internal Medicne

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BackgroundBrachycephalic dogs are at risk for arterial hypertension and obstructive sleep apnea, which are both associated with chronic magnesium (Mg) depletion.Hypothesis/ObjectivesTo compare the period prevalence of hypomagnesemia between Boxers and Bulldogs presented to a referral teaching hospital. To screen a group of Bulldogs for evidence of hypomagnesemia, and to obtain pilot data regarding the utility of parenteral Mg tolerance testing (PMgTT) in the diagnosis of whole‐body Mg deficiency.AnimalsChemistry laboratory submissions were retrospectively analyzed for serum total Mg (tMg) in Boxers and Bulldogs. Prospectively, 16 healthy client‐owned Bulldogs were enrolled.MethodsRetrospective case study. tMg concentrations were compared between Boxers and Bulldogs. Dogs with low serum albumin or high serum creatinine concentrations were excluded. Prospectively, ionized Mg (iMg), tMg, and arterial blood pressure were measured and iMg‐to‐tMg ratio (iMg : tMg) was calculated. Parenteral Mg tolerance testing (PMgTT) was performed in 3/16 dogs.ResultsIn the retrospective study, period prevalence of hypomagnesemia was 4.7% in Boxers and 15% in Bulldogs (P = .02). The risk ratio for hypomagnesemia in Bulldogs was 1.8 when compared to Boxers (CI: 1.3–2.7). In the prospective study, iMg was [median (interquartile)] 0.43 (0.42–0.46) mmol/L (reference range 0.4–0.52), tMg was 1.9 (1.8–1.9) mg/dL (reference range 1.9–2.5). iMg : tMg was [mean (±SD)] 0.59 ± 0.04. Percentage retention after PMgTT were 55%, 95%, and 67%, respectively.Conclusions and Clinical ImportanceMg deficiency is common in Bulldogs and could contribute to comorbidities often observed in this breed. iMg : tMg and PMgTT might prove helpful in detecting chronic subclinical Mg deficiency.

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“…Mg-28 has been employed since its discovery in 1953 for metabolic investigations in plants [24][25][26]. Followed by analogous studies on animals' physiology and metabolism for several decades [27][28][29][30][31][32][33][34][35][36][37][38]. The intrigue surrounding Mg-28's application for studying Mg's pathology, absorption, excretion, and metabolic dynamics within the human body has also captured researchers' attention [39][40][41][42][43][44][45][46][47].…”

Section: Overviewmentioning

confidence: 99%

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2023

Japan J Med Sci

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In this study, we have introduced a novel approach to cancer treatment involving the deactivation of metalloenzymes through the utilization of radioisotopes. The concept of leveraging radioisotopes to interact with metalloenzymes represents a groundbreaking theoretical advancement. Through simulations utilizing the MIRD code and based on the consistent concentration of stable Mg within stage 2A cancerous tissue, we have quantified the potential success rates.To conduct these simulations, we employed 0.1 nanograms (ng) of stable Mg, which corresponds to an activity of 19.7 MBq of Mg-28 radioisotope. This data was input into the MIRD calculations to estimate the absorbed doses within various organs, employing diverse methods of radioisotope administration into the body. Remarkably, even with a mere 0.1% probability of effectively reaching the intended cancerous tissues, this quantity of Mg-28 demonstrates the capability to render billions of Mg-containing metalloenzymes inactive.The remarkable efficiency achieved through precise radioisotope targeting underscores the promise of this methodology. Nevertheless, the findings underscore the necessity of undertaking both in vitro and in vivo research initiatives prior to embarking on clinical trials.

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Tissue distribution, kinetics, and biologic half-life of Mg²⁸ in the dog

Cited by 15 publications

References 0 publications

Plasma and Erythrocyte Magnesium in Thyroid Disease

Plasma and Erythrocyte Magnesium in Thyroid Disease

Hypomagnesemia in Brachycephalic Dogs

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Tissue distribution, kinetics, and biologic half-life of Mg28 in the dog

Cited by 15 publications

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Plasma and Erythrocyte Magnesium in Thyroid Disease

Plasma and Erythrocyte Magnesium in Thyroid Disease

Hypomagnesemia in Brachycephalic Dogs

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Tissue distribution, kinetics, and biologic half-life of Mg²⁸ in the dog