Tissue distribution of antimony (Sb) in piglets orally given graded levels of Sb (V)

Abstract

International audienceThe potential risks from oral intake of soil antimony (Sb) depends mainly on the amount of metal ingested and its bioavailability. Relative bioavailability may be determined by comparing Sb present in soil to a reference compound, taking into account accumulation in different target tissues or excretion. However, due to the lack of scientific knowledge concerning the fate of Sb in the organism, there is a need to study the absorption and distribution of Sb in order to select target tissues for assessment of bioavailability of Sb in soils. Thus, 45 piglets were exposed to a soluble pentavalent antimony salt (KSb(OH)6), for 15 days at concentrations ranging from 0-1600 mg Sb/kg body weight (BW) per day. Following the exposure period, blood, plasma, liver, spleen, kidneys, hair, bone, bile and urine were obtained to measure Sb concentrations by ICP-MS. Results showed that tissue Sb levels were dose-related. Higher Sb concentrations were found in urine, kidneys, hair, bone and liver. Sb(V) was not detectable in blood and plasma. In the case of highly contaminated soil with soluble forms of Sb in concentrations ranging from 200-1600 mg Sb/kg BW, kidneys, liver and spleen are the most reliable compartments to determine Sb bioavailability from soil. However, for the soils with lower levels of contamination and a low Sb bioaccessibility, urine may serve as a relevant compartmen

Leaching and In Vivo Bioavailability of Antimony in PET Bottled Beverages

“…The initial step of the RBA assessment was to assess the dose–response for Sb accumulation in the target tissue or organs in order to select a suitable endpoint for RBA assessment. Previous studies showed that the Sb distribution in mammals varied when different Sb species, such as Sb (V in potassium antimonate and Sb (III) in potassium tartrate (C 4 H 4 KO 7 Sb, APT), were utilized. , Our preliminary tests showed that Sb (III) was the main species in beverages following incubation at 60 °C for 7 days (Figure S1, the detailed process for Sb speciation can be found in Supporting Information), so APT was chosen as the reference compound to investigate Sb RBA. In addition, for the assessment of RBA, the properties of the reference material need to be similar to that of the samples to be assessed.…”