Tissue Distribution of Cadmium in Rats Given Minimum Amounts of Cadmium-Polluted Rice or Cadmium Chloride for 8 Months

Hiratsuka, Hideaki; Satoh, S.; Satoh, Masahiko; Nishijima, Motohiro; Katsuki, Yasutaka; Suzuki, Jin; Nakagawa, Junichi; Sumiyoshi, Masami; Shibutani, Makoto; Mitsumori, Kunitoshi; Tanaka-Kagawa, Toshiko; Ando, Masayuki

doi:10.1006/taap.1999.8768

Cited by 22 publications

(16 citation statements)

References 39 publications

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“…35 This discrepancy probably occurred because the previous study used a more balanced diet. In addition, other authors found a lower renal Cd concentration after exposure to 5 and 20 mg/kg diet (2 and 6 mg/g, respectively), 36 which may be related to the younger age of rats used in the present study. MM caused a small reduction in the Cd concentration and fractional Cd accumulation in the kidney of rats fed 5 mg/kg Cd.…”

Section: Discussionmentioning

confidence: 80%

Influence of cereal bran supplement on cadmium effects in growing rats

et al. 2009

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Strategies to diminish cadmium (Cd) absorption are highly desirable especially where Cd exposure due to environmental contamination is still inevitable. Cd toxicity may be influenced by dietary components, such as fiber and minerals. Multimixtures are low-cost cereal bran supplements used in Brazil and in other countries to counteract malnutrition in low-income populations. This study was aimed at evaluating whether multimixture would reduce Cd effects in young rats. Animals received a diet with or without the multimixture plus 0, 5, or 25 mg Cd/kg (control, Cd-5, and Cd-25 groups) during 30 days. The Cd-5 groups were similar to control groups in all parameters analyzed, except in the higher renal Cd concentration. However, the Cd-25 groups had lower biological growth parameters and renal δ-aminolevulinate dehydratase activity, besides higher renal Cd concentration and plasma alanine aminotransferase activity compared to the controls. The multimixture did not prevent Cd effects in the Cd-25 group, but caused a small reduction in renal Cd concentration in the Cd-5 group. Although this multimixture was ineffective to prevent Cd effects at the higher concentration, it seemed to reduce Cd accumulation at the lower Cd dietary concentration, which is similar to levels of human exposure in some polluted areas.

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Section: Discussionmentioning

confidence: 80%

Influence of cereal bran supplement on cadmium effects in growing rats

et al. 2009

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“…Cd metabolism in rats is well known and widely reported, and these animals have been commonly used as a good experimental model to study the impact of different factors on the body turnover of this metal and effects of its toxic action (Tandon and Tewari, ; Hopf et al ., ; Kershaw et al ., ; Sharma et al ., , ; Hiratsuka et al ., ; Ohta et al ., ; Pal et al ., ; Brzóska et al ., , , , , , ; Liu et al ., ; Moniuszko‐Jakoniuk et al, , ; Nowak et al ., ; Jurczuk et al ., , ; Kotyzova et al ., ; Galażyn‐Sidorczuk et al ., ; Vesey, ; Rogalska et al ., ). Since Cd absorption from the gastrointestinal tract of rats (0.2–2%) is lower than in humans (Hiratsuka et al ., ; Ohta et al ., ; Zalups and Ahmad, ), these animals need higher doses of this metal to reach blood and urinary concentrations similar to those noted in humans. The measurements of Cd in the blood and urine (main indicators of exposure) of the rats treated with 5 and 50 mg Cd l −1 confirmed that these levels of rat intoxication correspond to the exposure that may occur in humans (Galażyn‐Sidorczuk et al ., ; Chen et al ., ; Eum et al ., ; Forte et al ., ; González‐Estecha et al ., ; Huang et al ., ).…”

Section: Discussionmentioning

confidence: 98%

“…Cd is characterized by very strong cumulative properties in living organisms (Hiratsuka et al ., ; Ohta et al ., ; Brzóska et al ., , ; Liu et al ., ) and its retention in rats (expressed as the % R Cd ) was relatively high (above 64% and 76% in the 5 and 50 mg Cd l −1 groups, respectively). It is important to underline that the % R Cd reflects not only the amount of absorbed metal that is accumulated in various organs and tissues, but also its nonabsorbed pool present in the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 98%

Ethanol consumption modifies the body turnover of cadmium: a study in a rat model of human exposure

Brzóska

Gałażyn-Sidorczuk

Dzwilewska

2012

J of Applied Toxicology

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Ethanol (Et) abusers may also be exposed to excessive amounts of cadmium (Cd). Thus, the study was aimed at estimating the influence of Et on the body turnover of Cd in a rat model reflecting excessive alcohol consumption in humans chronically exposed to moderate and relatively high levels of this metal. For this purpose, Cd apparent absorption, retention in the body and concentration in the blood, stomach, duodenum, liver, kidney, spleen, brain, heart, testis and femur as well as its fecal and urinary excretion in the rats exposed to 5 and 50mg Cd l(-1) (in drinking water; for 16 weeks from the fifth week of the animal's life) and/or Et (5 g kg(-1) b.w. per 24 h, by oral gavage; for 12 weeks from the ninth week of life) were estimated. Moreover, the duodenal, liver and kidney pool of the nonmetallothionein (Mt)-bound Cd was evaluated. The administration of Et during the exposure to 5 or 50mg Cd l(-1) increased Cd accumulation in the gastrointestinal tract and its urinary excretion, and decreased Cd concentration in the blood, femur and numerous soft tissues (including liver and kidney) as well as the total pool of this metal in internal organs. Et modified or not the pool of the non-Mt-bound Cd, depending on the level of treatment with this metal. The results show that excessive Et consumption during Cd exposure may decrease the body burden of this metal, at least partly, by its lower absorption and increased urinary excretion. Based on this study, it can be concluded that Cd concentration in the blood and tissues of alcohol abusers chronically exposed to moderate and relatively high levels of this metal may be lower, whereas its urinary excretion is higher than in their nondrinking counterparts. However, since Et is toxic itself, the decreased body burden of Cd owing to alcohol consumption does not allow for the conclusion that the risk of health damage may be lower at co-exposure to these xenobiotics. In a further study, it will be investigated how the Et-induced changes in the body status of Cd influence the effects of its toxic action.

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“…In contrast, rats fed with the diet containing Cd at the levels close to those found in human foodstuffs (0.03-3 mg/kg), showed higher levels of Cd in kidney than liver (Scheuhammer 1988;Elsenhans et al 1992Elsenhans et al , 1997. Likewise, rats fed with contaminated rice consisting of Cd in the range of 0.1-1.0 mg/kg for 1, 4 and 8 months all showed higher levels of Cd in kidney than liver (Hiratsuka et al 1999). There is also evidence suggesting that Cd of dietary origin can deposit directly in kidney when it is absorbed in a complex with metallothionein (MT) induced by low-level Cd found in most normal diets (Elsenhans et al 1992(Elsenhans et al , 1997.…”

mentioning

confidence: 82%