Tissue distribution of some immune cells in bovine reproductive tract during follicular and luteal phase

Akbalık, Mehmet Erdem; Lïman, Narin; Sağsöz, Hakan; Saruhan, Berna Güney

doi:10.1002/jemt.22983

Cited by 6 publications

(5 citation statements)

References 58 publications

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“…ey are additionally involved in the induction of acute inflammation and tissue repair during chronic inflammation. In the female reproductive system, MCs are mainly distributed in the myometrium and endometrium layers [77], which are closely related to uterine smooth muscles, fibroblasts, and collagens. e mediators released by MCs can effectively stimulate uterine smooth muscle contractions.…”

Section: Mcsmentioning

confidence: 99%

Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective

Zhou

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The low adverse effects of acupuncture for primary dysmenorrhea (PD), known as one of the most commonly reported gynecological debilitating conditions affecting women’s overall health, have been thus far confirmed. Moreover, it has been increasingly recognized that inflammation is involved in such menstrual cramps, and recent studies have further shown that the anti-inflammatory effects of acupuncture are helpful in its control. This review portrays the role of inflammation in PD pathophysiology, provides evidence from clinical and animal studies on acupuncture for inflammation-induced visceral pain, and reflects on acupuncture-related therapies for dysmenorrhea with regard to their anti-inflammatory characteristics. Further research accordingly needs to be carried out to clarify the effects of acupuncture on proinflammatory factors in PD, particularly chemokines and leukocytes. Future studies on this condition from an anti-inflammatory perspective should be also performed in line with the notion of emphasizing stimulation modes to optimize the clinical modalities of acupuncture. Additionally, the effects and mechanism of more convenient self-healing approaches such as TENS/TEAS for PD should be investigated.

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Section: Mcsmentioning

confidence: 99%

Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective

Zhou

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Gastric tissue sample were obtained from the euthanized rats. The tissue samples taken were fixed in formalin-alcohol solution for 18 h and were embedded in paraffin after undergoing routine histological processing [13]. Five-micron-thick serial sections were cut from (Leica RM2235 Rotary microtome/Germany) the paraffin blocks at 100-lm intervals.…”

Section: Tissue Harvestingmentioning

confidence: 99%

“…The sections were counterstained using Gill' s Hematoxylin for 1 min and then washed in tap water until they turned blue. Sections were passed through graded alcohol series and xylol and then covered with entellan [13,14].…”

Section: Immunohistochemical Proceduresmentioning

confidence: 99%

The protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in rats

Karakoç,

Oruç,

Çeken–Toptancı

et al. 2024

RC FCV-LUZ

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The Pomegranate (Punica granatum) is a commonly found fruit in the Mediterranean and Iran, which has a variety of uses including medicinal purposes, cosmetics, and as a spice in culinary applications. Pharmacological functions of Pomegranate include antioxidation, anti–tumor, anti–hepatotoxicity, anti–lipoperoxidation and antibacterial properties. The aim of this study was to evaluate the therapeutic efficacy of Pomegranate extract by utilizing its antioxidant activity in an experimental rat model of gastritis induced by ethanol. In the study, 24 female Wistar albino rats (180–200 g) were used. Gastritis in rats was induced using Ethanol. In experimental groups, Tumor necrosis factor–alpha, Myloperoxidase, Superoxide Dismutase and Malondialdehyde were examined for biochemical analyzes. Streptavidin peroxidase immunohistochemistry method was applied to gastric tissues with gastritis. A statistically significant difference was observed between Superoxide Dismutase and Meloperoxidase levels. CD8 and CD68 immunoreactivity was higher in the Ethanol group compared to the other groups. A decrease was observed in CD8 and CD68 positive immunoreactivity in Ethanol+Pomegranate extract group compared to Ethanol group. The study found that the immunoreactivity of MHC–I and MHC–II was found in specific locations, namely intraepithelial lymphocytes located in the epithelium, some capillary vessel endothelium, and connective tissue. Changes in anti–oxidative stress markers such as Superoxide Dismutase and Myloperoxidase contributed to the mucosal protective effect of Pomegranate extract in Ethanol–induced gastritis.

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“…Overinfiltration andactivation cause enhancement in the pathogenesis of endometriosis [15], cancer and auto immune diseases [7]. Therefore, for a better understanding of their regulation, role within the uterus, it is necessary to know their quantity, localization and distribution, during different stages of estrus cycle in physiological conditions [16].…”

Section: Introductionmentioning

confidence: 99%

Temporal Variations in Density and Distribution of Neutrophils with Associated Morphological Changes in Uterus at All Stages of Estrus Cycle in Mice

Selvan,

Rajalakshmi,

Uma

et al. 2024

J. Adv. Biol. Biotechnol.

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Uterus is an important reproductive organ that undergoes proliferative, degenerative, repair and regenerative changes in its histological tunics during different stages of estrous cycle. These changes are temporal and are tightly regulated by the ovarian hormones. Derangements in remodeling is the reason for pathological conditions such as endometritis, endometriosis etc., The objective of the present study is to report on the % relative endometrial surface area, neutrophil density and their distribution in uterus at all stages of estrus cycle in normal mice to help understand the pathologies in unterine remodeling by abnormal neutrophil recruitment. All these temporo-spatial events are detected using Histomorphological, micro-morphometrical and immunohistochemical techniques. Our studies revealed that histomorphological variations were more pronounced in endometrium than other tunics. Histomorphometric studies found that the % relative endometrial surface area was maximum during late proestrus and early estrus. It reduced to its minimum levels in the middle of metestrus and was immediately restored within 6hrs. Histological and immunohistochemical studies confirmed that neutrophils were present during all stages of the estrus cycle. Their influx and density was maximum at early metestrus and was minimum at late metestrus. Their density were moderate and static thereafter until early proestrus. These findings suggested that the rate of infiltration of neutrophils in to uterus is a controlled and stage specific process. Their complex role of inflammation, phagocytosis and endometrial repair in remodeling the uterus may be dependent on the uterine microenvironment at a given time point.

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Tissue distribution of some immune cells in bovine reproductive tract during follicular and luteal phase

Cited by 6 publications

References 58 publications

Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective

Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective

The protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in rats

Temporal Variations in Density and Distribution of Neutrophils with Associated Morphological Changes in Uterus at All Stages of Estrus Cycle in Mice

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