2010
DOI: 10.1007/s10856-010-4007-7
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Tissue engineering approach to repair abdominal wall defects using cell-seeded bovine tunica vaginalis in a rabbit model

Abstract: The aim of this study was to engineer skeletal muscle tissue for repair abdominal wall defects. Myoblast were seeded onto the scaffolds and cultivated in vitro for 5 days. Full thickness abdominal wall defects (3 x 4 cm) were created in 18 male New Zealand white rabbits and randomly divided into two equal groups. The defects of the first group were repaired with myoblast-seeded-bovine tunica vaginalis whereas the second group repaired with non-seeded-bovine tunica vaginalis and function as a control. Three ani… Show more

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Cited by 26 publications
(23 citation statements)
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“…However, Vindigni et al performed a study on abdominal wall reconstruction using this single time point [12]. Additionally, the final results at 21 days are consistent with an effective abdominal wall repair, occurring even at an earlier time point with respect to previously published data on this argument [14,23].…”
Section: Discussionsupporting
confidence: 64%
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“…However, Vindigni et al performed a study on abdominal wall reconstruction using this single time point [12]. Additionally, the final results at 21 days are consistent with an effective abdominal wall repair, occurring even at an earlier time point with respect to previously published data on this argument [14,23].…”
Section: Discussionsupporting
confidence: 64%
“…Currently, the repair of large soft tissue de abdominal wall defects is a complex surgeons and continues to be a significa patients [14]. Free muscle transfer from sites is commonly employed for the su muscle tissue defects, but this practic associated with significant donor-site Therefore, alternative approaches includin of naturally derived biomaterials scaffolds pericardium [16], porcine small intestinal and acellular dermal matrix [18] have be repair abdominal wall defects in exper models.…”
Section: Discussionmentioning
confidence: 99%
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“…The impact of cellbased tissue engineering approaches on functional recovery from VML injuries is now commonly studied, and these approaches represent a well-documented way to leverage the existing injured tissue environment to provide the necessary components to accelerate and/or enhance muscle recovery. In fact, current preclinical reports employ multiple cell types, as well as a variety of natural or synthetic scaffolds, with demonstrable success in terms of improved functional recovery of VML injuries [Conconi et al, 2005;De Coppi et al, 2005;Kroehne et al, 2008;Moon du et al, 2008;Ayele et al, 2010;Merritt et al, 2010a;Borselli et al, 2011;Machingal et al, 2011;Page et al, 2011;Rossi et al, 2011;Fuoco et al, Corona et al, 2013aCorona et al, , b, 2014Juhas et al, 2014;Pilia et al, 2014;Madden et al, 2015]. In contrast, more limited functional outcomes generally result from implantation of acellular scaffolds alone [De Coppi et al, 2006;Kin et al, 2007;Merritt et al, 2010b;Turner et al, 2010;Aurora et al, 2015].…”
Section: Cell-based Tissue Engineering Approaches To Skeletal Muscle mentioning
confidence: 99%
“…Las matrices más utilizadas se corresponden con matrices de dermis porcina (Permacol), dermis de cadáver humano (Alloderm, matriz dérmica acelular derivada humana), dermis bovina y otras (colágeno, etc.) (21)(22)(23)(24)(25).…”
Section: Figura 1 Ejemplo De Una Malla Abdominal Infectada (8)unclassified