Tissue Engineering for Bone Production- Stem Cells, Gene Therapy and Scaffolds

Khaled, E G; Saleh, Maamoon; Hindocha, Sandip; Griffin, Michelle; Khan, Wasim

doi:10.2174/1874325001105010289

Cited by 59 publications

(52 citation statements)

References 31 publications

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“…32 Recently, the development of gene therapy has also provided a new approach for regenerating tissues, which can modify the implanted cells genetically using viral and non-viral vectors in order to strengthen bone tissue regeneration. 33,34 Although BTE have achieved significant improvement in animal models and clinic treatment, it is still difficult to get full success in this field. 35 …”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

The management of naso-orbital-ethmoid (NOE) fractures

Wei

Tang

Liu

et al. 2015

Chinese Journal of Traumatology

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The bony naso-orbital-ethmoid (NOE) complex is a 3-dimensional delicate anatomic structure. Damages to this region may result in severe facial dysfunction and malformation. The management and optimal surgical treatment strategies of NOE fractures remain controversial. For a patient with NOE trauma, doctors should perform comprehensive clinical examination and radiographic analysis to assess the type and extent of fracture. The results of assessment will assist doctors to make a patient-specific program for the sake of reducing post-operation complications and restoring normal appearance and function as much as possible. This review focuses on the advancement of management of NOE fractures including symptoms, classifications, diagnosis, approaches, treatment and new techniques in this field.Due to the naso-orbital-ethmoid (NOE) complex's intricate anatomy, the fracture in this region has been one of the most challenging to manage in maxillofacial trauma. The NOE complex is a 3-dimensional delicate anatomic structure. Damage to any structure in this region, even minimal, is quite likely to result in the facial function and appearance abnormal. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTFurthermore, this complex structure has a compact relationship with the brain and eyes, because it separates the nasal, orbital cavities from cranial cavity. Therefore, as long as the fracture of the region is suspected, a thorough physical examination and radiographic assessment, such as 2-dimensional (2D) CT and 3-dimensional (3D) CT, must be performed to assess the type and extent of fracture after achieving the stable vital signs.At present, different types of approaches for exposure have been discussed, such as midfacial degloving and endoscopic approach, as well as management of the NOE fracture, such as bone tissue engineering. However, every procedure has its advantages and disadvantages. According to individual injures, the surgeon should select the patient-specific treatment to restore the normal facial function and appearance. This review will discuss the advancement in the field of NOE fracture management. NOE anatomy Bony structure: the NOE complex consists of the nasal bones, frontal process of the maxilla, nasal process of the frontal bone, lacrimal bone, lamina papyracea, ethmoid bone, sphenoid bone and nasal septum, which separate the nasal, orbital cavities from cranial cavity. 1,2 The medial orbital wall is made up of the lacrimal bone and the lamina papyracea of the ethmoid where blowout fracture is easy to occur (Figure 1). 1 Medial canthal tendon (MCT): MCT is the pivotal soft tissue in NOE area, which supports the canthus, enables proper apposition between the eyelid and the globe, and performs as the lacrimal pump. 2 However, there are many controversies on the anatomy of MCT. The main controversy is on the number of the tendon's limbs. Some scholars referred that it had three limbs: anterior, superior, posterior, 2 some others argued that the superior limb did not exist. 3 Furthermore, some report...

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Section: Bone Tissue Engineeringmentioning

confidence: 99%

The management of naso-orbital-ethmoid (NOE) fractures

Wei

Tang

Liu

et al. 2015

Chinese Journal of Traumatology

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“…However, several complications are associated with bone marrow aspiration such as pain, infection and increased risks of morbidity. Following these findings, other sources of MSCs have been investigated such as synovium, adipose tissue and tendon [67, 68], but their differentiation and regenerative capacities are not clearly defined [71, 72]. …”

Section: Stem Cellsmentioning

confidence: 99%

Growth Factors and Stem Cells for the Management of Anterior Cruciate Ligament Tears

Rizzello¹,

Longo²,

Petrillo³

et al. 2012

TOORTHJ

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The anterior cruciate ligament (ACL) is fundamental for the knee joint stability. ACL tears are frequent, especially during sport activities, occurring mainly in young and active patients. Nowadays, the gold standard for the management of ACL tears remains the surgical reconstruction with autografts or allografts. New strategies are being developed to resolve the problems of ligament grafting and promote a physiological healing process of ligamentous tissue without requiring surgical reconstruction. Moreover, these strategies can be applicable in association surgical reconstruction and may be useful to promote and accelerate the healing process. The use of growth factors and stem cells seems to offer a new and fascinating solution for the management of ACL tears. The injection of stem cell and/or growth factors in the site of ligamentous injury can potentially enhance the repair process of the physiological tissue. These procedures are still at their infancy, and more in vivo and in vitro studies are required to clarify the molecular pathways and effectiveness of growth factors and stem cells therapy for the management of ACL tears. This review aims to summarize the current knowledge in the field of growth factors and stem cells for the management of ACL tears.

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“…These constructs or scaffolds facilitate tissue formation by enabling cell migration, proliferation, and differentiation [9, 22]. …”

Section: Response Of Cells To Different Biomaterials In Ligament Tmentioning

confidence: 99%

Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction

Yates

Rupani

Foley

et al. 2012

Stem Cells International

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Tissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented in the repair and regeneration of tissue such as bone, cartilage, tendon, and ligament. Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research is needed to improve the biomechanical properties of the engineered ligament if it is to play an important part in the future of human ligament reconstruction surgery. We evaluate the current literature on ligament tissue engineering and its role in anterior cruciate ligament reconstruction.

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Tissue Engineering for Bone Production- Stem Cells, Gene Therapy and Scaffolds

Cited by 59 publications

References 31 publications

The management of naso-orbital-ethmoid (NOE) fractures

The management of naso-orbital-ethmoid (NOE) fractures

Growth Factors and Stem Cells for the Management of Anterior Cruciate Ligament Tears

Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction

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