Tissue engineering of the gastroesophageal junction

Vogt, Caleb; Panoskaltsis‐Mortari, Angela

doi:10.1002/term.3045

Cited by 11 publications

(4 citation statements)

References 93 publications

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“…In addition to their contribution to Hp colonization and spread, the transition zones at the cardia and corpus-antrum border may also represent areas of increased oncogenic potential. Similar to the regional specification of the glandular stomach discussed previously, the delineation between the esophagus and the stomach at the gastroesophageal junction arises from a gradient of transcription factor expression as well as from communication between the mesenchyme and endoderm ( Vogt and Panoskaltsis-Mortari, 2020 ). For example, Hoxa5 expression in the mesenchyme of murine embryos stimulates patterned expression of the transcription factors Sonic hedgehog ( Shh ) in esophageal epithelium and Indian Hedgehog ( Ihh ) in columnar gastric epithelium ( McCracken K. W. and Wells J. M., 2017 ).…”

Section: Introductionmentioning

confidence: 89%

Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia’s Pattern of Spread Throughout the Stomach

Sáenz

2021

Front. Cell Dev. Biol.

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The human stomach functions as both a digestive and innate immune organ. Its main product, acid, rapidly breaks down ingested products and equally serves as a highly effective microbial filter. The gastric epithelium has evolved mechanisms to appropriately handle the myriad of injurious substances, both exogenous and endogenous, to maintain the epithelial barrier and restore homeostasis. The most significant chronic insult that the stomach must face is Helicobacter pylori (Hp), a stomach-adapted bacterium that can colonize the stomach and induce chronic inflammatory and pre-neoplastic changes. The progression from chronic inflammation to dysplasia relies on the decades-long interplay between this oncobacterium and its gastric host. This review summarizes the functional and molecular regionalization of the stomach at homeostasis and details how chronic inflammation can lead to characteristic alterations in these developmental demarcations, both at the topographic and glandular levels. More importantly, this review illustrates our current understanding of the epithelial mechanisms that underlie the pre-malignant gastric landscape, how Hp adapts to and exploits these changes, and the clinical implications of identifying these changes in order to stratify patients at risk of developing gastric cancer, a leading cause of cancer-related deaths worldwide.

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Section: Introductionmentioning

confidence: 89%

Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia’s Pattern of Spread Throughout the Stomach

Sáenz

2021

Front. Cell Dev. Biol.

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“…The challenge is to move from reconstruction limited to trials to reconstruction for a large number of patients, notably by limiting the costs of the product to remain accessible. Contrarily, the reconstruction of the gastroesophageal junction will undoubtedly pose more problems [100,101]. Indeed, such a reconstruction would imply a particular architecture and the creation of a transition zone between the epithelia.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Elia

Brownell

Chabaud

et al. 2022

IJMS

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The gastrointestinal and genitourinary tracts share several similarities. Primarily, these tissues are composed of hollow structures lined by an epithelium through which materials need to flow with the help of peristalsis brought by muscle contraction. In the case of the gastrointestinal tract, solid or liquid food must circulate to be digested and absorbed and the waste products eliminated. In the case of the urinary tract, the urine produced by the kidneys must flow to the bladder, where it is stored until its elimination from the body. Finally, in the case of the vagina, it must allow the evacuation of blood during menstruation, accommodate the male sexual organ during coitus, and is the natural way to birth a child. The present review describes the anatomy, pathologies, and treatments of such organs, emphasizing tissue engineering strategies.

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“…The challenge is to move from reconstruction limited to trials to reconstruction for a large number of patients, notably by limiting the costs of the product to remain accessible. Contrarily, the reconstruction of the gastroesophageal junction will undoubtedly pose more problems [92,93]. Indeed, such a reconstruction would imply a particular architecture and the creation of a transition zone between the epithelia.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Elia¹,

Brownell²,

Chabaud³

et al. 2022

Preprint

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The gastrointestinal and genitourinary tracts share several similarities. Primarily, these tissues are composed of hollow structures lined by an epithelium through which materials need to flow with the help of peristalsis brought by muscle contraction. In the case of the gastrointestinal tract, solid or liquid food must circulate to be digested and absorbed and the waste products eliminated. In the case of the urinary tract, the urine produced by the kidneys must flow to the bladder, where it is stored until its elimination from the body. Finally, in the case of the vagina, it must allow the evacuation of blood during menstruation, accommodate the male sexual organ during coitus, and is the natural way to birth a child. The present review describes the anatomy, pathologies and treatments of such organs, emphasizing tissue engineering strategies.

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Tissue engineering of the gastroesophageal junction

Cited by 11 publications

References 93 publications

Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia’s Pattern of Spread Throughout the Stomach

Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia’s Pattern of Spread Throughout the Stomach

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

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