2006
DOI: 10.1002/bjs.5343
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Tissue engineering of vascular conduits

Abstract: In vitro and in vivo approaches are currently being used for guided cell repopulation of both biological and synthetic scaffolds. The major clinical problem has been extended culture time (approximately 6 weeks), which precludes their use in the acute setting. However, recent advances have led not only to improved patency rates for prostheses, but also to a potential reduction in culture time. In addition, increased mobilization of endothelial progenitor cells in the presence of ischaemic tissue may increase t… Show more

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Cited by 68 publications
(54 citation statements)
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“…18,19 For the mass production of small-diameter, off-the-counter vascular grafts, considered to be the ''Holy Grail'' of vascular tissue engineering, 20,21 it is necessary to develop a cost-effective, reliable, and efficient seeding technique. 22 This technique can be either using seeding a scaffold before implantation 11,13,23 or by using manufactured preseeded scaffolds.…”
Section: Introductionmentioning
confidence: 99%
“…18,19 For the mass production of small-diameter, off-the-counter vascular grafts, considered to be the ''Holy Grail'' of vascular tissue engineering, 20,21 it is necessary to develop a cost-effective, reliable, and efficient seeding technique. 22 This technique can be either using seeding a scaffold before implantation 11,13,23 or by using manufactured preseeded scaffolds.…”
Section: Introductionmentioning
confidence: 99%
“…Major drawbacks of biodegradable polymers include their inherent stiffness before implantation, lack of natural adhesive proteins and specific ligands, and the difficulty encountered in the process of creating balance between the matrix degradation time and the reconstruction of a new matrix [Cebotari et al, 2002]. Premature degradation leading to rupture, aneurysmal dilatation and intimal hyperplasia are other major limitations restricting the use of biodegradable polymer constructs in vascular applications [Yow et al, 2006]. Natural collagens are major structural proteins in the ECM of the arterial wall accounting for 20-50% of the dry weight of the arterial wall [Bartos and Ledvina, 1979].…”
Section: Cell Scaffold Technologymentioning
confidence: 99%
“…The EPCs can be derived easily from patients' own blood or bone marrow. The increase in circulation EPCs in response to stimuli of vascular injury, hypoxia and ischemia offers an excellent opportunity for easy harvesting either from venesection or non-depleting selfrenewing source (blood) for vascular tissue engineering grafts [Sales et al, 2005;Yow et al, 2006]. For a fully biocompatible small-diameter vascular graft with good long-term patency and functionality, apart from the functional autologous endothelium, a completely autologous scaffold with sufficient biomechanical properties is the other key requirement.…”
Section: Accessibility/completely Autologous Scaffoldmentioning
confidence: 99%
“…Instead, various approaches have been suggested to create vessel grafts from natural or biocompatible scaffolds seeded with vascular cells [2]. These tissue engineering procedures usually in volve incubations in perfusion bioreactors which provide suitable conditions for graft development.…”
Section: Introductionmentioning
confidence: 99%