Tissue expression of CA 125 in benign and malignant lesions of ovary and fallopian tube: A comparison with CA 19-9 and CEA

Neunteufel, W.; Breitenecker, G.

doi:10.1016/0090-8258(89)90628-8

Cited by 49 publications

(26 citation statements)

References 15 publications

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“…CA-125 positivity was detected in 90% of carcinomas in the present study, being seen most often in ovarian and endometrial tumours (97% and 100%, respectively). These results are in agreement with other studies of ovarian carcinomas [27,37]; the moderate enhancement in sensitivity possibly resulted from our antigen exposure procedure. Notably, all fallopian tube controls were CA-125 positive, as described in the above studies.…”

Section: Discussionsupporting

confidence: 94%

“…However, since the initial report of Bast et al [3], several studies have demonstrated CA-125 positivity in the benign epithelium of the female genital tract, and also in the normal lung, serous membranes, various inflammatory processes, and malignant mesotheliomas [4,9,19,27,28]. In contrast, no CA-125 positivity was found in adult ovaries [37], and weak to negative staining was seen in cultured mesothelial cells [36].…”

Section: Discussionmentioning

confidence: 89%

“…Carcinoembryonic antigen (CEA) has been evaluated as a marker for malignant epithelial cells in effusions in numerous studies [1,2,11,14,20,22,23,26,27,32,33,35]. The sensitivity of CEA immunostaining in these studies ranges from zero to 100%.…”

Section: Discussionmentioning

confidence: 99%

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Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies

Davidson¹,

Risberg²,

Kristensen

et al. 1999

Virchows Archiv

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The detection of malignant cells in pleural, peritoneal, and pericardial fluids of cancer patients marks the presence of metastatic disease and is associated with a grave prognosis. We evaluated five epithelial markers for the detection of cancer cells in 94 fresh pleural, peritoneal and pericardial effusions. Eighty-four of the samples were regarded as adequate for analysis after evaluation of cytological smears, including 61 samples from patients known to have gynaecological neoplasms. The other 23 samples were from patients with various non-gynaecological malignancies or tumours of unknown origin. Our control cases were 10 fallopian tubes not affected by any malignancy and 12 malignant mesotheliomas. Cell blocks from all cases were stained for CA-125, BerEP4, carcinoembryonic antigen (CEA), BG8 (Lewis Y blood antigen), and B72.3 (TAG-72). Fifty-one of 84 cases were diagnosed as malignant or suggestive of malignancy in cytological smears and/or cell block sections. However, staining for epithelial markers highlighted the presence of malignant cells in 7 additional cases. When membrane staining was evaluated, the sensitivity of the markers studied in detecting malignant cells was as follows: CA-125: 88%, BerEP4: 78%, CEA: 26%, BG8: 86%, B72.3: 79%. Membrane positivity for CEA, B72.3 and BerEP4 was not detected in reactive mesothelial cells. However, membranous staining in mesothelial cells was evident in 13% and 31% of cases with the use of BG8 and CA-125, respectively. Weak cytoplasmic staining for CEA was observed in mesothelial cells in 2 cases. When Ber-EP4, B72.3, and BG8 staining results in cancer cells were combined, the following sensitivity levels were observed: BG8+B72.3: 91%; BG8+Ber-EP4: 90%; B72.3+Ber-EP4: 93%; BG8+Ber-EP4+B72.3: 95%. The detection of malignant cells in effusions is facilitated by the use of immunocytochemistry using a wide panel of antibodies. BerEP4 and B72.3 appear to be the best markers when both sensitivity and specificity are considered, followed by BG8, while CEA and CA-125 have a limited role in the detection of metastases from gynaecological tumours owing to the low sensitivity of the former and the low specificity of the latter. Analysis of all staining results should be based on a thorough morphological examination.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 89%

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Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies

Davidson¹,

Risberg²,

Kristensen

et al. 1999

Virchows Archiv

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show abstract

“…Weaker expression of CA 125 in tissue could also be a result of heterogeneity of tumors, since not all serous carcinomas express the CA 125 antigen [8], or could be the result of inadequate tissue sampling. CA 125 expression in tumor tissue has been found markedly heterogenous: tumor areas with strong, weak, and no reaction were adjacent [12]. It is also possible that weaker expression of the antigen in tissue could be due to its poor retrieval during tissue processing.…”

Section: Discussionmentioning

confidence: 93%

Influence of tumor grade on expression of CA 125 in serum and tissue in patients with serous ovarian carcinoma

But¹

2003

Wien Klin Wochenschr

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“…[19][20][21][22] In en domet ri o sis, se rum le vel of CA 125 and CA 19-9 is ex pec ted to be no mo re than 100 IU/ml and 1000 IU/ml, res pec ti vely. Ho we ver, very high se rum levels of CA 125 and CA 19-9 (CA 125: 9537 IU/ml, CA 19-9: 15.653 IU/ml) was re cor ded in a pa ti ent with rup tu red ova ri an en do met ri o ma.…”

Section: Medical Pathologymentioning

confidence: 99%

Uterus-Like Ovarian Mass with Elevated Serum Levels of CA 19-9 and CA 125: A Case Report and Review of the Literature

Kelten¹,

Yalçin²,

Çoban³

et al. 2010

Turkiye Klinikleri J Med Sci

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Tissue expression of CA 125 in benign and malignant lesions of ovary and fallopian tube: A comparison with CA 19-9 and CEA

Cited by 49 publications

References 15 publications

Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies

Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies

Influence of tumor grade on expression of CA 125 in serum and tissue in patients with serous ovarian carcinoma

Uterus-Like Ovarian Mass with Elevated Serum Levels of CA 19-9 and CA 125: A Case Report and Review of the Literature

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