Tissue Healing and Repair: Tendons and Ligaments

Oakes, Barry W

doi:10.1002/9780470757178.ch4

Cited by 14 publications

(26 citation statements)

References 93 publications

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“…Long-lasting massage (60 days) resulted in the reduction of fibril diameter which is characteristic for tendon tissue in young rats [9]. Oakes (1981;1988) obtained similar results on ligaments of young rats subjected to exercises in the form of swimming or running in a treadmill [9]. They demonstrated a decrease of the mean diameter of collagen fibrils in the group subjected to exercises as compared to the control group.…”

Section: Discussionsupporting

confidence: 56%

“…The results obtained in this study seem to be beneficial for the tendon's tissue physiology. Long-lasting massage (60 days) resulted in the reduction of fibril diameter which is characteristic for tendon tissue in young rats [9]. Oakes (1981;1988) obtained similar results on ligaments of young rats subjected to exercises in the form of swimming or running in a treadmill [9].…”

Section: Discussionsupporting

confidence: 55%

“…It was demonstrated that the diameter of collagen fibrils increases in tendons with the ageing process [9].…”

Section: Discussionmentioning

confidence: 99%

“…Massage was performed using spiral rubbing technique on dorsal-lateral surface of the tail (on the right and left side). The rat tail tendons were selected for the experiment, as they are described in details in literature, taking into account distribution of diameters of the collagen fibrils in relation to the age of the animal [9]. Moreover, the tendons did not undergo strain associated with the activity of the animals.…”

Section: Methodsmentioning

confidence: 99%

“…An www.fhc.viamedica.pl intensive running and training therapy manual shows relatively well documented factors affecting collagen fibrils [9]. It is known that strenuous sports training can lead to tendon and ligament injury.…”

Section: Introductionmentioning

confidence: 99%

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Massage-induced morphological changes of dense connective tissue in rat’s tendon

Kassolik

Andrzejewski

Dzięgiel

et al. 2013

Folia Histochem Cytobiol.

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Abstract:The aim of the experiment was to determine if possible changes in connective tissue induced by massage could have a positive effect justifing the use of massage in all post-traumatic connective tissue conditions, e.g. tendon injuries. The investigations were performed in a group of 18 Buffalo rats. The rats were divided into two groups (experimental and control). To standardize the massage procedure, it was performed with an algometer probe of 0.5 cm 2 with constant pressure force of 1 kG (9,81 N). To analyse the number and diameter of collagen fibrils, two electron micrographs were performed for each rat of the collected segments of tendons of rat tail lateral extensor muscle. After image digitalization and calibration, the measurements were carried out using iTEM 5.0 software. The number of fibrils, their diameter and area were measured in a cross-sectional area. An increase of the number of collagen fibrils was observed in the tendons of massaged animals compared to the control group. Our study demonstrated that massage may cause a beneficial effect on metabolic activity of tendon's fibroblasts and, in consequence, may be applied for more effective use of massage for the prevention of tendon injury as well as after the injury has occurred.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionsupporting

confidence: 55%

“…It was demonstrated that the diameter of collagen fibrils increases in tendons with the ageing process [9].…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Massage-induced morphological changes of dense connective tissue in rat’s tendon

Kassolik

Andrzejewski

Dzięgiel

et al. 2013

Folia Histochem Cytobiol.

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Acmella oleracea extract increases collagen content and organization in partially transected tendons

Moro

Fujii

Teodoro

et al. 2021

Microscopy Res & Technique

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Acmella oleracea contains spilanthol as the main active compound, which possesses analgesic and anti‐inflammatory effects that can favor tendon reorganization. To analyze the effect of A. oleracea on the content and organization of collagen in injured tendons, the calcaneal tendon of male Lewis rats was partially transected and treated at the site of injury with a topical application of 20% A. oleracea ointment (AO group) or with the ointment base without the plant extract (B group). The animals were euthanized 21 days after partial transection. Higher collagen concentration was observed in the AO group than in the B group, and morphological analysis using polarization microscopy showed higher birefringence in the AO group than in the B group, indicating higher collagen organization. No difference was observed in the number of fibroblasts, blood vessels, proteoglycan distribution, and maximum load between the B and AO groups. In conclusion, topical application of 20% A. oleracea ointment increased the molecular organization and content of collagen, thus indicating a potential application in tendon repair. Studies on the later phases of the tendon healing process are necessary to demonstrate the possible biomechanical changes after the application of A. oleracea ointment.

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MRL/MpJ tendon matrix‐derived therapeutic promotes improved healing outcomes in scar‐mediated canonical tendon healing

Paredes

Pekmezian

Andarawis‐Puri

2020

Journal Orthopaedic Research

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Tendons are commonly injured connective soft tissues characterized by an ineffective healing response that results in scar formation and loss of functional and structural properties. Naturally occurring extracellular matrix (ECM) constructs have become a promising therapeutic for tendon injuries due to their capacity to harness a complex biological environment. However, in tendon, the ECM properties needed for improved healing remain unknown. Interestingly, we have determined that the improved tendon healing response of the scarless‐healing MRL/MpJ is driven by intrinsic properties with therapeutic potential to modulate the proliferative and morphological behavior of cells derived from a canonically healing model in vitro. We hypothesize that a distinct composition of ECM deposited during the early healing response of the MRL/MpJ will harnesses the biological cues to stimulate improved structure and function in vivo of canonically healing B6 mice. Accordingly, MRL/MpJ and B6 patellar tendons were injured via midsubstance punch defects. Healing tendons were isolated after 3 or 7 days and encapsulated in PEG‐4MAL hydrogels to develop ECM‐derived therapeutic constructs. Constructs were then introduced into B6 mice as a treatment following full thickness midsubstance‐punch injuries. Treatment with ECM‐derived constructs from MRL/MpJ tendons after 7‐days post‐injury (M7) resulted in improved matrix alignment, tissue stiffness, decreased collagen III content and improved cell morphology in B6 tendons after 6 weeks post‐injury. Furthermore, proteomic analysis showed that M7 contained a unique compositional profile rich in glycoproteins, thereby elucidating a valuable naturally‐derived platform for the treatment of tendon injuries. Overall this work highlights promising targets for future therapeutic development and tissue engineering applications.

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Tissue Healing and Repair: Tendons and Ligaments

Cited by 14 publications

References 93 publications

Massage-induced morphological changes of dense connective tissue in rat’s tendon

Massage-induced morphological changes of dense connective tissue in rat’s tendon

Acmella oleracea extract increases collagen content and organization in partially transected tendons

MRL/MpJ tendon matrix‐derived therapeutic promotes improved healing outcomes in scar‐mediated canonical tendon healing

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