Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer

Holten-Andersen, Mads Nikolaj; Nielsen, Hans Jørgen; Sørensen, Steen; Jensen, Vibeke; Brünner, Nils; Christensen, Ib Jarle

doi:10.1016/j.ejca.2006.01.058

Cited by 41 publications

(31 citation statements)

References 23 publications

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“…Other researchers have also observed the relation between the level of TIMP-1 protein in plasma and other parameters such as primary tumor location in colon, the presence of metastases to lymph nodes and distant organs, the attachment of blood and lymph vessels, and the growth of serum CEA level [20,24,25]. Holten-Andersen et al [21] noted the increase in the level of TIMP-1 protein in postoperative plasma of patients with CRC compared to the control group. However, the concentration of the protein did not differ notably from its level in preoperative plasma of patients with CRC [21].…”

Section: Discussionmentioning

confidence: 99%

“…Holten-Andersen et al [21] noted the increase in the level of TIMP-1 protein in postoperative plasma of patients with CRC compared to the control group. However, the concentration of the protein did not differ notably from its level in preoperative plasma of patients with CRC [21]. According to this study, which was based on the ELISA method, a statistically significantly higher level of TIMP-1 protein in the sera of patients with CRC compared to the healthy control group was observed.…”

Section: Discussionmentioning

confidence: 99%

“…In the preoperative plasma, the increase in TIMP-1 protein level in patients with CRC was related to the patient's age. The level of the protein increased in the elderly [20][21][22][23][24]. Moreover, the increase in TIMP-1 level also correlated with Dukes' D stage of cancer [20,25,26].…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic significance of TIMP-1 level in serum and its immunohistochemical expression in colorectal cancer patients

Niewiarowska¹,

Pryczynicz²,

Dymicka-Piekarska³

et al. 2014

pjp

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Tissue inhibitor of metalloproteinase-1 (TIMP-1) inhibits the ability of cancer cells to metastasize, but it can also stimulate cancer development. The aim of this study was to assess the level of TIMP-1 in serum and its expression in patients with colorectal cancer (CRC). The study group consisted of 43 patients diagnosed with colorectal cancer and 24 healthy volunteers. The level of TIMP-1 was assessed by the ELISA method while the expression of this protein was performed immunohistochemically. The concentration of TIMP-1 in the sera of colorectal cancer patients was significantly higher than in the healthy control group (p = 0.004). Higher level of TIMP-1 in the sera correlated with female gender (p = 0.045), tumor location in colon (p = 0.016), poorly differentiated tumor (p = 0.034) and higher platelet count in whole blood (p < 0.004). A positive reaction of the protein in cancer cells was observed in 31 cases and was found to correlate negatively with its reaction in peritumoral stroma (p < 0.001). According to this study, TIMP-1 protein may play an important role in cancer development. The assessment of this molecule in serum and tissue can be useful at the time of diagnosis and can help us to understand the nature of colorectal pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diagnostic significance of TIMP-1 level in serum and its immunohistochemical expression in colorectal cancer patients

Niewiarowska¹,

Pryczynicz²,

Dymicka-Piekarska³

et al. 2014

pjp

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“…Thus, plasma TIMP-1 was a significant prognosticator not only for short-term survival but also for long-term survival in patients with colorectal cancer. Recently, Holten-Andersen et al [15, 16] stratified patients into four groups according to pre- and postoperative plasma TIMP-1 and demonstrated a significant association between plasma TIMP-1 and long-term survival. Moreover, they described that the combination of postoperative plasma TIMP-1 and carcinoembryonic antigen was a significant marker for survival [16].…”

Section: Discussionmentioning

confidence: 99%

Impact of Plasma Tissue Inhibitor of Matrix Metalloproteinase-1 on Long-Term Survival in Patients with Colorectal Cancer

Yukawa

Yoshikawa²,

Amaki³

et al. 2007

Oncology

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Tissue inhibitor of metalloproteinase-1 (TIMP-1) not only inhibits matrix metalloproteinases but also stimulates tumor growth. In this study, long-term follow-up results were analyzed to clarify the prognostic value of plasma TIMP-1. Preoperative plasma TIMP-1 was measured from peripheral blood samples of 87 Japanese patients with colorectal carcinoma. All the patients underwent surgical resection and were followed for 5 years prospectively. The median follow-up period was 70 months (60–79 months). The cutoff value of plasma TIMP-1 was set at 170 ng/ml based on the ROC curve. Sensitivity and specificity to predict 5-year survival was 66.7 and 55.0% with this cutoff value. In univariate analyses for overall survival, lymph node metastasis, serosal invasion, peritoneal metastasis, liver metastasis, metastasis to other distant organs and TIMP-1 were significant. In multivariate analyses, lymph node and liver metastases, metastasis to other distant organs and plasma TIMP-1 were independent prognosticators, but p values of TIMP-1 did not reach statistical significance. Our results suggested that the preoperative plasma TIMP-1 concentration could be a useful prognosticator of long-term survival in patients with colorectal carcinoma.

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“…Plasma TIMP-1 concentrations are known to be elevated in CRC and particularly in CC [24]. Preoperative plasma TIMP-1 levels have prognostic value for overall survival (OS) [22], and plasma TIMP-1 levels determined in postoperative samples have been shown to predict short OS, risk of local and distant metastases [25].…”

Section: Introductionmentioning

confidence: 99%

Positron emission tomography/computed tomography for optimized colon cancer staging and follow-up.

Engelmann

Loft

Kjær

et al. 2014

JCO

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Objectives. Optimal management of colon cancer (CC) requires detailed assessment of extent of disease. This study prospectively investigates the diagnostic accuracy of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/ computed tomography (PET/CT) for staging and detection of recurrence in primary CC. Material and methods. PET/ CT for preoperative staging was performed in 66 prospectively included patients with primary CC. Diagnostic accuracy for PET/CT and CT was analyzed. In addition to routine follow up, 42 stages I-III CC patients had postoperative PET/CT examinations every 6 months for 2 years. Serological levels of tissue inhibitor of metalloproteinase-1 (TIMP-1), carcinoembryonic antigen, and liberated domain I of urokinase plasminogen activator receptor were analyzed. Results. Accuracy for tumor, nodal, and metastases staging by PET/CT were 82% (95% confidence interval [CI]: 70; 91), 66% (CI: 51; 78), and 89% (CI: 79; 96); for CT the accuracy was 77% (CI: 64; 87), 60% (CI: 46; 73), and 69% (CI: 57; 80). Cumulative relapse incidences for stages I-III CC at 6, 12, 18, and 24 months were 7.1% (CI: 0; 15); 14.3% (CI: 4; 25); 19% (CI: 7; 31), and 21.4% (CI: 9; 34). PET/CT diagnosed all relapses detected during the first 2 years. High preoperative TIMP-1 levels were associated with significant hazards toward risk of recurrence and shorter overall survival. Conclusions. This study indicates PET/CT as a valuable tool for staging and follow up in CC. TIMP-1 provided prognostic information potentially useful in selection of patients for intensive follow up.

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Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer

Cited by 41 publications

References 23 publications

Diagnostic significance of TIMP-1 level in serum and its immunohistochemical expression in colorectal cancer patients

Diagnostic significance of TIMP-1 level in serum and its immunohistochemical expression in colorectal cancer patients

Impact of Plasma Tissue Inhibitor of Matrix Metalloproteinase-1 on Long-Term Survival in Patients with Colorectal Cancer

Positron emission tomography/computed tomography for optimized colon cancer staging and follow-up.

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